Chemistry, Biochemistry, and Pharmacological Activity of Prostanoids

Including the Proceedings of a Symposium on the Chemistry and Biochemistry of Prostanoids Held at The University of Salford, England, 10-14 July 1978

Stanley M. Roberts, Feodor Scheinmann

• Publisher: Pergamon
• Year: 2013
• Print ISBN:
  9780080237992
• eBook ISBN:
  9781483146034
• Topic: Biological Sciences
• Subtopic: Zoology
• Index: Biological Sciences

Chemistry, Biochemistry, and Pharmacological Activity of Prostanoids contains the proceedings of a symposium on the Chemistry and Biochemistry of Prostanoids held at the University of Salford, England on July 10-14, 1978. Separating 29 papers of the symposium as chapters, this book begins with a description of prostanoids in health and disease and recent developments in the synthesis of antisecretory prostaglandins. Other topics discuss synthesis of some novel 11-deoxyprostaglandins; bicycles, tricycles and prostaglandin synthesis; chemical and biological studies on new prostanoids; and isolation and characterization of enzymes involved in prostaglandin biosynthesis. Structure activity relationships of prostaglandins and a biochemical background of caloric restriction therapy of obesity are also explained.

Table of contents

• Front Cover
• Chemistry, Biochemistry, and Pharmacological Activity of Prostanoids
• Copyright Page
• Table of Contents
• Preface
• CHAPTER 1. PROSTANOIDS IN HEALT HAND DISEASE
• CHAPTER 2. RECENT DEVELOPMENTS IN THE SYNTHESIS OF AMISECRETORY PROSTAGLANDINS
• CHAPTER 3. SYNTHESIS OF SOME NOVEL11-DEOXYPROSTAGLANDINS
• CHAPTER 4. SYNTHESIS AND BRONCHIAL DILATOR ACTIVITY OF SOME NOVEL PROSTAGLANDIN ANALOGUES (1)
• CHAPTER 5. BICYCLES, TRICYCLES AND PROSTAGLANDIN SYNTHESIS
• CHAPTER 6. THE TOTAL SYNTHESIS OF (±) PROSTAGLANDIN Di
• CHAPTER 7. CHEMICAL AND BIOLOGICAL STUDIES ON NEW PROSTANOIDS
• CHAPTER 8. A METHOD FOR THE INVERSION OF CONFIGURATION OF ALCOHOLS
• CHAPTER 9. THE SYNTHESIS OF COMPOUNDS FORMED IN THE ARACHIDONIC ACID CASCADE AND AGENTS WHICH MODULATE THEIR PRODUCTION
• CHAPTER 10. ON THE EXISTENCE OF etQj-OXY-11,15-DIHYDROXYPROSTA-Z.ia-DIENOIC ACID
• CHAPTER 10. NOVEL METABOLITES OF ARACfflDONIC ACID
• CHAPTER 11. BICYCLO [3,2,0] KEPT AN-2-0NES; A PHOTOCHEMICAL ROUTE TO PROSTANOID SYNTHONS
• CHAPTER 12. THE SYNTHESIS OF GYGLOPENTENOLONE PRECURSORS TO PROSTAGLANDINS FROM FURAN DERIVATIVES
• CHAPTER 13. A GENERAL SYNTHESIS OF THE PROSTAGLANDINS FROM BUTADIENE AND LEVULINIC ACID
• CHAPTER 14. A NEW STEREOSELECTIVE SYNTHESIS OF PROSTAGLANDINS
• CHAPTER 15. BIOLOGICALLY ACTIVE 11-DEOXYPROSTAGLANDINS
• CHAPTER 16. THROMBOXANE-LIKE ACTIVITY OF PROSTANOIDS WITH AROMATIC SUBSTITUENTS AT C16 AND C17
• CHAPTER 17. BIOSYNTHESIS OF PROSTAGLAND INSAND THROMBOXANES
• CHAPTER 18. ISOLATION AND ΟΗΑΚΑΟΤΕΚΙΖΑΉΟΝ OF ENZYMES INVOLVED IN PROSTAGLANDIN BIOSYNTHESIS
• CHAPTER 19. 15-DEOXY-16-HYDROXYPROSTAGLANDINS SYNTHESIS AND BRONCHODILATOR ACTIVITY
• CHAPTER 20. PROSTACYCLIN FORMATION AND EFFECTS
• CHAPTER 21. SYNTHESIS AND STEREOCHEMISTRY OF STABLE PROSTACYCLIN ANALOGS
• CHAPTER 22. SYNTHESIS AND BIOLOGICAL PROPERTIES OF PROSTACYCLINS AND PROSTAGLANDIN ENDOPEROXIDE ANALOGS
• CHAPTER 23. THE 6(9)ΟΧΥ CYCLASE PATHWAY OF PROSTAGLANDIN ENDOPEROXIDE METABOLISM
• CHAPTER 24. THE GASTRIC ANTISECRETORY PROPERTIES OF SOME PROSTAGLANDIN ANALOGUES
• CHAPTER 25. STRUCTURE-ACTIVITY RELATIONSHIPS OF PROSTAGLANDINS
• CHAPTER 26. THE CLEAVAGE OF SILYLOXY GROUPS BY BORON TRIFLUORIDE ETHERATE
• CHAPTER 27. 15-DEOXY-16-HYDROXY-PGEi CARBINOLS SYNTHESIS AND BIOLOGICAL ACTIVITY
• CHAPTER 28. A BIOCHEMICAL BACKGROUND OF CALORY RESTRICTION THERAPY OF OBESITY: LIPID PEROXIDE MOBILIZATION
• CHAPTER 29. THE SYNTHESIS AND BIOLOGICAL PROPERTIES OF 9a, lla-TRITHIOGARBONATEOF 9, lla-BISDESOXY-PGFi.A MIMIG OF PROSTAGLANDINENDOPEROXIDES
• AUTHOR INDEX
• SUBJECT INDEX