Lymphokines

A Forum for Immunoregulatory Cell Products

Edgar Pick

• Publisher: Academic Press
• Year: 2014
• Print ISBN:
  9780124320086
• eBook ISBN:
  9781483266992
• Topic: Biological Sciences
• Subtopic: Biochemistry
• Index: Biological Sciences

Lymphokines: A Forum for Immunoregulatory Cell Products deals with immunoregulatory cell products that produce lymphokines. Topics covered include the purification and characterization of transfer factor; activation of cytotoxicity and/or suppressor activity in murine macrophages by lymphokines, lipopolysaccharide, and polyinosinic-polycytidylic acid; and the role of clotting processes in the action of lymphokines on macrophages. A comparison of the immune-modulating effects of interferon and interferon inducers is also presented. Comprised of 13 chapters, this volume begins with a discussion on transfer factor and its ability to react specifically with antigens. The clinical uses of transfer factor are considered with special emphasis on its value as a prophylactic agent. The reader is then introduced to the subject of T cell regulation of the immunoglobulin E (IgE) response via potentiating and suppressor lymphokines, together with the possible clinical application of IgE suppressive factors in the treatment of atopic diseases. Subsequent chapters examine the evidence in favor of the existence of T cell-derived polyclonal B cell activator (PBA) playing a role in both normal antibody responses and autoimmune diseases; the role of suppressor T cells and the associated lymphokines in contact sensitivity in mice; and lymphokine action on macrophages. The book also analyzes the genetics of the response of human and mouse cells to interferons. This monograph will be helpful to practitioners and researchers in the fields of microbiology and immunology.

Table of contents

• Front Cover
• Lymphokines: A Forum for Immunoregulatory Cell Products
• Copyright Page
• Table of Contents
• Contributors
• Preface
• Chapter 1. Transfer Factor
• Chapter 2. IgE-Binding Factors from Rat T Lymphocytes
• Chapter 3. A Polyclonal B-Cell Activating Lymphokine and Its Natural Inhibitor: Possible Role in Antibody Formation and Autoimmune Diseases
• Chapter 4. Lymphokines and Antigen-Specific T-Cell Products in Contact Sensitivity
• Chapter 5. Studies on the Activation of Cytotoxicity and/or Suppressor Activity in Murine Macrophages by Lymphokines, Lipopolysaccharide, and Polyinosinic—Polycytidylic Acid
• Chapter 6. The Role of Clotting Processes in the Action of Lymphokines on Macrophages
• Chapter 7. A Chemically Defined Monokine: Macrophage-Derived Platelet-Activating Factor (PAF-Acether)
• Chapter 8. Genetic Control of the Response to Interferon in Man and Mouse
• Chapter 9. A Comparison of Immune Modulating Effects of Interferon and Interferon Inducers
• Chapter 10. Ciliary Dyskinesia Factors Produced by Leukocytes
• Chapter 11. Ceruloplasmin: An Acute Phase Reactant and Antioxidant
• Chapter 12. Properties and Action Mechanism of Clastogenic Factors
• Chapter 13. The Biological Effects and Mechanism of Action of the Plasma Tripeptide Glycyl-L-histidyl-L-lysine
• Index