Visceral Leishmaniasis and Post-kala-azar Dermal Leishmaniasis

Pathogenesis, Treatment and Disease Control

Veer Singh, Ashish Kumar

• Publisher: CRC Press
• Year: 2025
• eBook ISBN: 9781040300244
• Edition: 0
• Topic: Biological Sciences
• Subtopic: Immunology
• Index: Biological Sciences

This reference book explores various aspects of visceral leishmaniasis (VL) and post-kala-azar dermal leishmaniasis (PKDL), including their pathophysiology, treatment options, and disease control strategies. The initial chapter provides an overview of VL, its global impact, and pathogenesis. It also examines the development of PKDL from VL, outlining the transition from the acute form of the disease to the chronic dermal condition. The book further explores the symptoms and diagnosis of both VL and PKDL. Furthermore, the book delves into the immunopathogenesis of both VL and PKDL, shedding light on the complex interactions between the parasite and the host immune system. It reviews the impact of environmental factors, particularly the contamination of arsenic and antimony in drinking water, on the progression of the disease. Lastly, the book discusses preventive measures for PKDL and highlights the major challenges in effectively implementing these strategies. This book serves as a useful resource for researchers, healthcare professionals, and policymakers seeking to deepen their understanding of these diseases and develop effective strategies for their prevention and control.

Key features

• Provides in-depth coverage of VL and PKDL, including pathogenesis, treatment, and disease control strategies
• Elucidates the symptoms and diagnostic methods for VL and PKDL
• Offers insights into the complex immunopathogenesis of VL and PKDL, exploring the interactions between parasites and host immune system
• Examines treatment options for both VL and PKDL, including current therapeutic approaches and emerging strategies
• Reviews the impact of environmental factors, such as arsenic and antimony contamination, on the disease progression
• Discusses preventive measures and challenges in implementing effective strategies for PKDL prevention and control

Table of contents

• Cover
• Half-Title
• Title
• Copyright
• Dedication
• Contents
• Preface
• Acknowledgements
• Editors
• Contributors
• Chapter 1 General Introduction to Visceral Leishmaniasis
• Chapter 2 Geographical Distribution of VL and PKDL in India
• Chapter 3 Visceral Leishmaniasis as a Public Health Problem in India: Action Toward its Elimination
• Chapter 4 Pathogenesis of Visceral Leishmaniasis
• Chapter 5 A Current Scenario of Drug Discovery Against Visceral Leishmaniasis
• Chapter 6 Major Challenges in Visceral Leishmaniasis Treatment
• Chapter 7 Post-kala-azar Dermal Leishmaniasis Development from Visceral Leishmaniasis
• Chapter 8 Symptoms and Diagnosis of Visceral Leishmaniasis and Post-kala-azar Dermal Leishmaniasis
• Chapter 9 Molecular Mechanism of PKDL Development
• Chapter 10 Immunopathogenesis of Visceral Leishmaniasis and Post-kala-azar Dermal Leishmaniasis
• Chapter 11 A Recent Update on Visceral Leishmaniasis and Post-kala-azar Dermal Leishmaniasis: Epidemiology, Diagnosis, and Treatments
• Chapter 12 Review of Existing Control Measures for VL and PKDL: Innovative Approaches to Vector Control, Case Management, Vaccine Development, and Community Education
• Chapter 13 Public Health Implications and Challenges of VL and PKDL
• Chapter 14 Role of Environmental Factors on the Development of PKDL
• Chapter 15 Arsenic and Antimony Toxicity in Drinking Water and Their Roles in the Development of PKDL
• Chapter 16 Government Policies toward Providing Safe Drinking Water to the Public
• Chapter 17 Factors Influencing the Development of Post-kala-azar Dermal Leishmaniasis
• Index