- 210 pages
- English
- ePUB (mobile friendly)
- Available on iOS & Android
eBook - ePub
About this book
mRNA Therapeutics: Foundations, Innovations and Clinical Applications aims to provide a comprehensive text that covers all aspects of mRNA therapeutics, from the foundational science that underpins this disruptive new drug class, through the scientific and technological breakthroughs crucial for therapeutic success, to the current clinical applications and the innovative advances driving future directions. The book begins with foundational knowledge covering mRNA biology, the immune system, and vaccines. The second section addresses the major challenges associated with mRNA as a therapeutic modality, and the molecular engineering innovations and delivery technologies that have allowed these hurdles to be largely overcome. The third section describes the current and future clinical applications of mRNA therapeutics that are transforming, or are poised to transform, medicine and health. This includes the use of mRNA vaccines for COVID-19 and other infectious diseases, as well as mRNA's role in revolutionizing cancer immunotherapy, covering immunostimulants, cancer vaccines including personalized neoantigen vaccines, and CAR T cell technologies. Additional chapters describe the use of mRNA therapeutics for protein replacement therapy and gene-editing, as well as newer mRNA constructs, including self-amplifying mRNA. The final section addresses the safety and regulatory considerations of mRNA therapeutics, along with broader cultural issues including vaccine hesitancy, global vaccine inequality, and pandemic preparedness. Currently, mRNA texts either provide personal accounts from key players involved in COVID-19 vaccine development, with limited scientific depth, or focus on highly specialized, more esoteric applications of mRNA in advanced molecular biology. This book aims to bridge this gap by providing a scientifically rigorous and wide-ranging exploration of mRNA's role in therapeutics. This pioneering textbook serves as a vital addition to the academic canon, providing an essential tool for the current and next generation of students, scientists, researchers and professionals in a wide variety of related disciplines including molecular biology, biomedical engineering, pharmaceutical science, oncology, and the health sciences.
- Focuses on the science of mRNA, covering the development, modus operandi, platform manufacturing technology, safety, and efficacy of this treatment modality
- Provides the mRNA technology fit with the wider context of vaccinology, virology, oncology, biotechnology, as well as manufacturing and regulatory science
- Offers an understanding of the recent paradigm shift in the way we treat disease
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Please note we cannot support devices running on iOS 13 and Android 7 or earlier. Learn more about using the app.
Yes, you can access mRNA Therapeutics by Anya Hillery in PDF and/or ePUB format, as well as other popular books in Medicine & Pharmacology. We have over one million books available in our catalogue for you to explore.
Information
Table of contents
- Cover
- Front Matter
- Table of Contents
- Copyright
- Preface
- Acknowledgements
- Introduction
- List of Illustrations
- List of Tables
- Chapter 1 : Introduction to mRNA and mRNA-based therapeutics
- Chapter 2 : Overview of the immune system and introduction to vaccines
- Chapter 3 : The science of mRNA: structure, design innovations and synthesis via IVT
- Chapter 4 : Delivery systems for mRNA
- Chapter 5 : mRNA vaccines for COVID-19
- Chapter 6 : mRNA-based cancer therapeutics
- Chapter 7 : Further therapeutic applications of mRNA and saRNA
- Chapter 8 : Vaccine efficacy, safety, and regulatory controls
- Chapter 9 : mRNA vaccines: public health and societal challenges
- Conclusions
- Index
- A