Denitrogenative Transformation of Nitrogen Heterocycles

Synthesis, Reactions and Applications

Pazhamalai Anbarasan

• Publisher: Wiley-VCH
• Year: 2024
• Print ISBN: 9783527353163
• eBook ISBN: 9783527844838
• Edition: 1
• Topic: Physical Sciences
• Subtopic: Industrial & Technical Chemistry

Comprehensive resource exploring a unique chemical transformation that generates new compounds with diverse properties for modern organic synthesis research

Denitrogenative Transformation of Nitrogen Heterocycles explores all 10 polynitrogen heterocycles that are known to undergo denitrogenative transformations to date. Following highlights on the remarkable modifications encountered in the synthesis of nitrogen heterocycles, the chapters use a reaction-based approach to explain denitrogenative transformations in detail.

This book covers the exponential growth in scientific literature in the last few decades for denitrogenative reactions of polynitrogen heterocycles which play a key role in natural products, medicinal chemistry, pharmaceuticals, biochemistry, and material sciences. This book also discusses denitrogenative cascade reactions, which accomplish powerful transformations from simple polynitrogen heterocycles to more complex molecules in modern synthetic chemistry.

Written by a highly qualified academic with significant experience in the field, Denitrogenative Transformation of Nitrogen Heterocycles covers sample topics including:

• Transannulation of N-sulfonyl-1,2,3-triazoles with polar multiple bonds such as carbonyls and nitriles and non-polar multiple bonds such as alkenes, alkynes, and allenes
• Insertion of azavinyl carbenes to C–X/X–X bond, denitrogenative rearrangements of N-sulfonyl-1,2,3-triazoles, and denitrogenative transformations of NH- and N-fluoroalkyl-1,2,3-triazoles
• Metal-catalyzed and metal-free denitrogenative transformations of pyridotriazoles and denitrogenative transannulation of benzotriazoles and thiadiazoles
• Denitrogenative transformations of tetrazoles and radical denitrogenative transformations of polynitrogen heterocycles

The first book of its kind on the subject, Denitrogenative Transformation of Nitrogen Heterocycles is an essential reference for researchers and scientists working in organic chemistry, organometallic chemistry, and transition metal catalysis, as well as academics and industry professionals in related fields.

Table of contents

• Cover
• Title Page
• Copyright
• Contents
• Preface
• Chapter 1 Synthesis of Diverse Nitrogen Heterocycles Explored in Denitrogenative Transformations
• Chapter 2 Transannulation of N‐Sulfonyl‐1,2,3‐triazoles with Polar Multiple Bonds
• Chapter 3 Transannulation of N‐Sulfonyl‐1,2,3‐triazoles with Nonpolar Multiple Bonds such as Alkenes, Alkynes, and Allenes
• Chapter 4 Transannulations of N‐Sulfonyl‐1,2,3‐triazoles with Carbo/Heterocycles
• Chapter 5 Insertion of Azavinyl Carbenes to CH/XH Bond
• Chapter 6 Insertion of Azavinyl Carbenes to CX/XX Bond
• Chapter 7 Denitrogenative Rearrangements of N‐Sulfonyl‐1,2,3‐triazoles
• Chapter 8 Denitrogenative Transformations of NH‐ and N‐Fluoroalkyl‐1,2,3‐triazoles
• Chapter 9 Asymmetric Perspective on Denitrogenative Transformation of 1,2,3‐Triazoles
• Chapter 10 Denitrogenative Transformations of 3‐Diazoindolin‐2‐imines
• Chapter 11 Metal‐Catalyzed Denitrogenative Transformations of Pyridotriazoles
• Chapter 12 Metal‐Free Denitrogenative Transformation of Pyridotriazoles
• Chapter 13 Recent Development in Denitrogenative Transannulation of Benzotriazoles
• Chapter 14 Denitrogenative Transannulation of Thiadiazoles
• Chapter 15 Denitrogenative Transformations of Benzotriazinones and Related Compounds
• Chapter 16 Denitrogenative Transformations of 3‐Aminoindazoles
• Chapter 17 Denitrogenative Transformations of Tetrazoles and Pyridotetrazoles
• Chapter 18 Radical Denitrogenative Transformations of Polynitrogen Heterocycles
• Chapter 19 Application of Denitrogenative Transformations in Synthesis of Natural Products
• Index
• EULA