Advancing Prion Science
eBook - PDF

Advancing Prion Science

Guidance for the National Prion Research Program

,
  1. 289 pages
  2. English
  3. PDF
  4. Available on iOS & Android
eBook - PDF

Advancing Prion Science

Guidance for the National Prion Research Program

,

About this book

In Advancing Prion Science, the Institute of Medicines Committee on Transmissible Spongiform Encephalopathies Assessment of Relevant Science recommends priorities for research and investment to the Department of Defenses National Prion Research Program (NPRP). Transmissible spongiform encephalopathies (TSEs), also called prion diseases, are invariably fatal neurodegenerative infectious diseases that include bovine spongiform encephalopathy (commonly called mad cow disease), chronic wasting disease, scrapie, and Creutzfeldt-Jakob disease. To develop antemortem diagnostics or therapies for TSEs, the committee concludes that NPRP should invest in basic research specifically to elucidate the structural features of prions, the molecular mechanisms of prion replication, the mechanisms of TSE pathogenesis, and the physiological function of prions normal cellular isoform. Advancing Prion Science provides the first comprehensive reference on present knowledge about all aspects of TSEs"e;from basic science to the U.S. research infrastructure, from diagnostics to surveillance, and from prevention to treatment.

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Information

Publisher
National Academies Press
Year
2004
eBook ISBN
9780309527149
Edition
0
Topic
Medicine

Table of contents

  1. FrontMatter
  2. Reviewers
  3. Preface
  4. Acknowledgments
  5. Abbreviations and Acronyms
  6. Contents
  7. Figures, Tables, Boxes, and Plates
  8. Executive Summary
  9. Summary
  10. 1 Introduction
  11. 2 Prion Diseases: An Overview
  12. 3 Basic Biomedical Research on Transmissible Spongiform Encephalopathies
  13. 4 Diagnostics for Transmissible Spongiform Encephalopathies
  14. 5 Testing Blood for Evidence of the Agents of Transmissible Spongiform Encephalopathies
  15. 6 Surveillance for Transmissible Spongiform Encephalopathies in the United States
  16. 7 Assessment of Strategies to Prevent and Treat Transmissible Spongiform Encephalopathies
  17. 8 Infrastructure for Research on Transmissible Spongiform Encephalopathies
  18. 9 Risk of Transmissible Spongiform Encephalopathies to the U.S. Military
  19. APPENDIXES
  20. A Agendas of Open Sessions of Committee Meetings
  21. B Biographical Sketches
  22. Glossary
  23. PLATES