Phthalates and Cumulative Risk Assessment

The Tasks Ahead

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• Publisher: National Academies Press
• Year: 2008
• eBook ISBN: 9780309128421
• Edition: 0
• Topic: Biological Sciences
• Index: Biological Sciences

People are exposed to a variety of chemicals throughout their daily lives. To protect public health, regulators use risk assessments to examine the effects of chemical exposures. This book provides guidance for assessing the risk of phthalates, chemicals found in many consumer products that have been shown to affect the development of the male reproductive system of laboratory animals.Because people are exposed to multiple phthalates and other chemicals that affect male reproductive development, a cumulative risk assessment should be conducted that evaluates the combined effects of exposure to all these chemicals. The book suggests an approach for cumulative risk assessment that can serve as a model for evaluating the health risks of other types of chemicals.

Table of contents

• FrontMatter
• Preface
• Contents
• Abbreviations
• Summary
• 1 Introduction
• 2 Phthalate Exposure Assessment in Humans
• 3 Toxicity Assessment
• 4 Current Practice in Risk Assessment and Cumulative Risk Assessment
• 5 Cumulative Risk Assessment of Phthalates and Related Chemicals
• 6 Data Gaps and Research Needs
• Appendix A: Statement of Task
• Appendix B: Biographic Information on the Committee on Health Risks of Phthalates
• Appendix C: Analysis of a Mixture of Five Phthalates: A Case Study
• Appendix D: Evaluating Multiple End Points Simultaneously in a Mixture of Three Antiandrogens: A Case Study