Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment
eBook - ePub

Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment

,
  1. English
  2. ePUB (mobile friendly)
  3. Available on iOS & Android
eBook - ePub

Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment

,

About this book

The new field of toxicogenomics presents a potentially powerful set of tools to better understand the health effects of exposures to toxicants in the environment. At the request of the National Institute of Environmental Health Sciences, the National Research Council assembled a committee to identify the benefits of toxicogenomics, the challenges to achieving them, and potential approaches to overcoming such challenges. The report concludes that realizing the potential of toxicogenomics to improve public health decisions will require a concerted effort to generate data, make use of existing data, and study data in new ways--an effort requiring funding, interagency coordination, and data management strategies.

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Edition
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Table of contents

  1. COVER PAGE
  2. THE NATIONAL ACADEMIES
  3. COMMITTEE ON APPLICATIONS OF TOXICOGENOMIC TECHNOLOGIES TO PREDICTIVE TOXICOLOGY
  4. BOARD ON ENVIRONMENTAL STUDIES AND TOXICOLOGY
  5. BOARD ON LIFE SCIENCES
  6. OTHER REPORTS OF THE BOARD ON ENVIRONMENTAL STUDIES AND TOXICOLOGY
  7. OTHER REPORTS OF THE BOARD ON LIFE SCIENCES
  8. Preface
  9. Acknowledgments
  10. Acknowledgment of Review Participants
  11. Abbreviations
  12. Contents
  13. BOXES, FIGURES, AND TABLES
  14. Summary
  15. 1 Introduction
  16. 2 Toxicogenomic Technologies
  17. 3 Experimental Design and Data Analysis
  18. 4 Application to Exposure Assessment
  19. 5 Application to Hazard Screening
  20. 6 Application to Analyzing Variation in Human Susceptibility
  21. 7 Application to the Study of Mechanisms of Action
  22. 8 Other Potential Applications of Toxicogenomic Technologies to Risk Assessment
  23. 9 Validation
  24. 10 Sample and Data Collection and Analysis
  25. 11 Ethical, Legal, and Social Issues
  26. 12 Conclusions and Recommendations
  27. References
  28. Appendix A Biographic Information on the Committee on Applications of Toxicogenomic Technologies to Predictive Toxicology
  29. Appendix B Minimum Information About a Microarray Experiment for Toxicogenomics1
  30. Appendix C Overview of Risk Assessment