Andrographolide and its Analogs: Botanical Sources, Phytochemistry, Pharmacology, and Biotechnology

S. Karuppusamy, Vinod K. Nelson, T. Pullaiah

• Publisher: Bentham Science Publishers
• Year: 2024
• eBook ISBN: 9789815256567
• Edition: 0
• Topic: Medicine
• Subtopic: Biotechnology in Medicine

This book provides an in-depth and comprehensive overview of andrographolides and their analogues, highlighting their botanical origins, phytochemistry, pharmacological properties, and biotechnological applications. It explores the isolation, purification, and spectroscopic characterization of andrographolides from natural sources, emphasizing their therapeutic potential in antidiabetic studies and other medicinal uses. The book also explains cultivation techniques, agronomic strategies for Andrographis species, genetic improvements, and in vivo extraction methods aimed at enhancing andrographolide yields, with a focus on commercial cultivation and export strategies. Dedicated chapters, contributed by experts, discuss the ethnobotanical significance of Andrographis species, traditional medicinal formulations, and advanced biotechnological interventions for conservation and utilization. Recent breakthroughs in understanding andrographolides' biosynthesis, metabolism, safety aspects, and promising applications in treating diabetes, cancer, inflammation, liver diseases, and neurological disorders are also covered. Readers will gain insight into how andrographolide analogues can be developed as "lead molecules" for creating next-generation phytodrugs. Key Features · Provides a comprehensive account of andrographolide-producing plant sources and their phytochemical and pharmacological properties. · Explores the role of biotechnology in enhancing andrographolide production through in vivo and in vitro methods. · Highlights the therapeutic efficacy of andrographolides and analogues in antidiabetic, anticancer, hepatoprotective, and anti-inflammatory drug development. · Discusses cutting-edge advancements in the biosynthesis and semisynthetic derivatives of andrographolides. · Covers cultivation, agronomic techniques, and genetic improvements to optimize andrographolide production for commercial applications. This book is a valuable resource for researchers, pharmacologists, biotechnologists, and biomedical professionals focused on natural product-based drug discovery involving andrographolide. Readership Pharmaceutical chemists, pharmacologists, researchers and biotechnologists.

Table of contents

• Welcome
• Table of Content
• Title
• BENTHAM SCIENCE PUBLISHERS LTD.
• PREFACE
• List of Contributors
• Andrographolides – An Overview
• Botany of Andrographis Wall. ex Nees (Andrographinae: Acanthaceae)
• Ethnobotany of the Genus Andrographis Wall. ex Nees (Acanthaceae)
• Andrographolide and its Analogs
• Pharmacognostic Characterization of Andrographis paniculata (Burm. f.) Nees
• Pharmacology of Andrographolide and its Analogs: An Update
• Andrographolide and its Structural Analogs in Parkinson’s Disease
• Neuroprotective Potential of Andrographolide (AG) and its Structural Analogs in Alzheimer’s Disease
• The Importance of Andrographolide and its Analogs in Prostate Cancer
• Andrographolide and its Analogs in the Treatment of Lung Cancer: An Update
• Anticancer Potential of Andrographolide and its Analogs in Colorectal Cancer: An Update
• Andrographolide and its Analogs as Cardioprotective Agents
• Phytonanomaterials from Andrographis Species and their Applications
• Cultivation of Andrographis paniculata (Burm. f.) Nees
• Micropropagation of Andrographis Species - A Review
• In vitro Production of Medicinally Potential Andrographolides from Andrographis Species