Toxicological Assessment of Combined Chemicals in the Environment

De-Sheng Pei, Yiyun Liu

• Publisher: Wiley
• Year: 2025
• Print ISBN: 9781394158324
• eBook ISBN: 9781394158331
• Edition: 1
• Topic: Physical Sciences
• Subtopic: Organic Chemistry

Comprehensive resource covering toxicology fundamentals, distribution of pollutants in the environment, and research methodologies for toxicological assessment of chemical mixtures

Toxicological Assessment of Combined Chemicals in the Environment offers an in-depth exploration of various approaches and molecular mechanisms regarding how minor alterations in chemical mixtures can influence an organism's toxicity, along with discussion of the challenges associated with assessing mixtures.

The first section of the book provides a concise introduction to the background and significance of combined toxicity. Section two delves into the primary sources and enrichment mechanisms of different chemical mixtures, elucidating the biological exposure pathways of these compounds. Section three introduces both classical and emerging toxicological research models in detail. Building on the descriptions of compound emission, migration, accumulation, and transformation processes, and the analysis of combined molecular toxicity in the preceding sections, section four introduces computer mathematical modeling methods for hazard assessment of compound mixtures. The final section details the challenges and future trends in this field.

Written by a highly qualified author and seasoned research contributor in the field, Toxicological Assessment of Combined Chemicals in the Environment covers sample topics including:

• The degradation, oxidation, absorption, distribution, biotransformation, and excretion of various compounds in both the environment and in organisms
• A variety of cell models and in vivo research models of model organisms, supplemented with case studies
• Combined molecular toxicity mechanisms of heavy metals, pesticides, persistent organic pollutants (POPs), and pharmaceutical and personal care products (PPCPs)
• Principal sources, fate, and mechanism of chemical mixtures in the environment, as well as experimental designs and sampling strategies for combined toxicity studies based on concentrations

Toxicological Assessment of Combined Chemicals in the Environment serves as a valuable reference for researchers, students, and policymakers involved in environmental management and protection. It is particularly relevant for toxicologists, risk assessors, and those engaged in the molecular modeling of toxic mixtures.

Table of contents

• Cover
• Half Title Page
• Title Page
• Copyright
• Dedication
• Contents
• Foreword
• Preface
• Acknowledgments
• List of Contributors
• Chapter 1: Introduction to Combined Toxicology, Background, Key Terminologies, and Significance: Yingjie Xia
• Chapter 2: Toxicokinetics of Chemical Mixture Exposure in the Environment: Abdul Wahab Hussain, Mehvish Mumtaz, Asad Ullah Saeed, Maryam Mumtaz
• Chapter 3: Toxicodynamics of Chemical Mixtures Exposure in the Organism Body: Chunjiao Lu, Ting Yang, Xin Meng, Xiaojun Yang
• Chapter 4: Principal Sources, Fate, and Mechanism of Chemical Mixtures in the Environment: Bao-Fu Zhang, Yiyun Liu, De-Sheng Pei
• Chapter 5: Experimental Designs and Sampling Strategies for Combined Toxicity Studies Based on Concentrations: Manoharan Saravanan, Karunanithi Vidhya
• Chapter 6: Migration and Transformation of Chemical Pollutants as Mixtures: Xiang Ge, Yingxin Yu
• Chapter 7: Analytical Techniques Used to Detect Chemical Mixtures in the Environment: Thodhal Yoganandham Suman
• Chapter 8: Common Toxicological Experimental Models: Xuan Ma, Dejun Huang
• Chapter 9: Combined Molecular Toxicity Mechanism of Heavy Metals Mixtures: Kusheng Wu, Yuequn Chen, Wenlong Huang
• Chapter 10: Combined Molecular Toxicity Mechanism of Pesticide Mixtures: Ali Omar Jimale, Yiyun Liu, De-Sheng Pei
• Chapter 11: Combined Molecular Toxicity Mechanism of Persistent Organic Pollutant Mixtures: Ruijia Zhang, Tiangang Luan
• Chapter 12: Combined Molecular Toxicity Mechanism of Emerging Pollutant Mixtures: Xiangsheng Hong
• Chapter 13: Combined Molecular Toxicity Mechanism of Phthalate Mixtures: Yiyun Liu, De-Sheng Pei
• Chapter 14: Combined Molecular Toxicity Mechanism of Microplastics Mixtures: Ya Liu, Yin Liu
• Chapter 15: Combined Molecular Toxicity Mechanism of Flame Retardant Mixtures: Xinyan Li, Tiangang Luan
• Chapter 16: Adverse Outcome Pathways (AOPs) of Combined Pollutant Mixtures and Their Toxicogenetic Endpoints: Hossam El Din H. Abdelhafez, Mohamed Bedair M. Ahmed, Magdy Moheb El-Dein Saad
• Chapter 17: Mathematical Model for Combined Toxicity Prediction: Fasiha Javaid, De-Sheng Pei
• Chapter 18: Novel Quantitative Structure–Activity Relationship Tox21 Techniques for Combined Toxicity Prediction: Na Li
• Chapter 19: Challenges and Prospects in the Application of Experimental, Analytical, and Predictive Models in Combined Toxicity Assessment: Naima Hamid, Qiang Yue, Jun Wang, Muhammad Junaid
• Chapter 20: Future Research Perspectives of Combined Toxicology: Tariq Mehmood, Anam Ashraf, Kousar Parveen, Muhammad Azher Hassan, Muhammad Fahad Sardar, Muhammad Faheem, Licheng Peng, Shakeel Ahmad, Tauseef Ahmad, Predrag Ilic
• Chapter 21: Combined Toxicity of Chemicals: Final Thoughts and Concluding Remarks: De-Sheng Pei, Marriya Sultan, Yiyun Liu
• Index
• EULA