Pain

Current Understanding, Emerging Therapies, and Novel Approaches to Drug Discovery

Chas Bountra, Rajesh Munglani, William K. Schmidt

• Publisher: CRC Press
• Year: 2003
• eBook ISBN:
  9781135532505
• Topic: Medicine
• Subtopic: Medical Theory, Practice & Reference

This reference presents a detailed overview of approaches and techniques in the management of pain caused by tissue, nerve and central nervous system injuries, categorizing pain into a variety of syndromes and underlying mechanisms to aid the development of interventional pharmacologic measures.

Table of contents

• Cover
• Half Title
• Title Page
• Copyright Page
• Preface
• Table of Contents
• Contributors
• Pain
• 1 Mechanism-Based Classifications of Pain and Analgesic Drug Discovery
• 2 Sites of Analgesie Action
• 3 From Acute to Chronic Pain
• 4 Central and Peripheral Components of Neuropathic Pain
• 5 A New Perspective on Signal Transduction in Neuropathic Pain
• 6 Pain and the Somatosensory Cortex
• 7 Descending Pathways in Spinal Cord Stimulation and Pain Control
• 8 Local Neuroimmune Interactions in Visceral Hyperalgesia
• 9 Pain Processing in the Periphery
• 10 Neuroimaging of Pain
• 11 Surrogate Models of Pain
• 12 Acute Trauma and Postoperative Pain
• 13 Effectiveness of Needling Techniques with Special Reference to Myofascial Pain Syndromes
• 14 Advances in the Management of Spinal Pain and Radiofrequency Techniques
• 15 Pulsed Radiofrequency Treatment of Chronic Neck, Back, Sympathetic, and Peripheral Neuroma-Derived Pain
• 16 Spinal Cord Stimulation
• 17 Spinal Endoscopy
• 18 Cancer Pain Treatment
• 19 Inflammatory Joint Disease and Pain
• 20 Chronic Nonmalignant Visceral Pain Syndromes of the Abdomen, Pelvis, and Bladder and Chronic Urogenital and Rectal Pain
• 21 Nerve Injury Pain
• 22 Sympathetically Maintained Pain
• 23 Headache
• 24 Psychological Factors in Measurement of Pain
• 25 Challenges and Pitfalls of Clinical Trials
• 26 Molecular Approaches to the Study of Pain
• 27 Molecular Validation of Pain Targets
• 28 Genetics of Pain
• 29 Animal Models of Pain
• 30 An Overview of Current and Investigational Drugs for the Treatment of Acute and Chronic Pain
• 31 Novel Mu, Delta, and Kappa Agonists
• 32 Delta-Receptor, Nonpeptide Agonists
• 33 Peripheral Opioid Analgesia
• 34 Profile of ADL 2-1294, an Opioid Antihyperalgesic Agent with Selectivity for Peripheral Mu-Opiate Receptors
• 35 Controlled-Release Opioids
• 36 NMDA-Receptor Antagonists as Enhancers of Analgesic Activity
• 37 CCK Antagonist Potentiation of Opioid Analgesia
• 38 Profile of NSAID + Opioid Combination Analgesics
• 39 NSAIDs and COX-2 Inhibitors
• 40 COX-2-Specific Inhibitors
• 41 NK! Receptor Antagonists
• 42 Vanilloids
• 43 The Development of Bradykinin Antagonists as Therapeutic Agents
• 44 The Treatment of Neuropathic Pain
• 45 /V-Methyl-D-Aspartate (NMDA) Receptors as a Target for Pain Therapy
• 46 Profile of Ketamine, CPP, Dextromethorphan, and Memantine
• 47 GV 196771 A, a New Glycine Site Antagonist of the NMD A Receptor with Potent Antihyperalgesic Activity
• 48 Voltage-Gated Sodium Channels and Pain
• 49 Calcium Channel Antagonists and the Control of Pain
• 50 Profile of Ziconotide (SNX-111) A Neuronal N-Type Voltage-Sensitive Calcium Channel Blocker
• 51 Nitric Oxide Synthase Inhibitors and the Role oí Nitric Oxide in Nociception
• 52 Adenosine and Pain
• 53 Adenosine Kinase Inhibition as a Therapeutic Approach to Analgesia
• 54 P2X Purinergic Receptors for ATP in Nociception
• 55 Somatostatin Receptors in Analgesia
• 56 Cannabinoids
• 57 Antinociceptive Effects of Centrally Administered Neurotrophic Factors
• 58 Peripheral Neurotrophic Factors and Pain
• 59 Profile of Tramadol and Tramadol Analogues
• 60 Sumatriptan and Related 5-HT1b/id Receptor Agonists
• 61 Cholinergic Approaches to Pain Therapy
• 62 Analgesic Effects of Vedaclidine, a Mixed Agonist-Antagonist at Muscarinic Receptor Subtypes
• 63 Gabapentin and Related Compounds
• 64 The Role of Gabapentin in the Management of Neuropathic Pain
• 65 New Local Anesthetic Analgesics
• 66 Spinal a2-Ädrenergic Agonists for Intractable Cancer Pain
• 67 Cellular Implantation for the Treatment of Chronic Pain
• 68 Bone-Seeking Radiopharmaceuticals to Palliate Painful Bone Metastases
• Appendix I: Currently Marketed Analgesics (U.S.A.; 1998-2001) (compiled by William K. Schmidt)
• Appendix II: 21-Year Survey of Analgesics in Development for Treatment of Acute or Chronic Pain
• Further Readings
• Index