Clinical and Statistical Considerations in Personalized Medicine
eBook - ePub

Clinical and Statistical Considerations in Personalized Medicine

  1. English
  2. ePUB (mobile friendly)
  3. Available on iOS & Android
eBook - ePub

Clinical and Statistical Considerations in Personalized Medicine

About this book

Clinical and Statistical Considerations in Personalized Medicine explores recent advances related to biomarkers and their translation into clinical development. Leading clinicians, biostatisticians, regulators, commercial professionals, and researchers address the opportunities and challenges in successfully applying biomarkers in drug discovery and preclinical and clinical development.

Robust Biomarkers for Drug Development and Disease Treatment
The first four chapters discuss biomarker development from a clinical perspective. Coverage ranges from an introduction to biomarkers to advances in RNAi screens, epigenetics, and rare diseases as targets for personalized medicine approaches. Subsequent chapters examine the statistical considerations in applying a personalized medicine approach, including multiplicity in pharmacogenomics. The last chapter assesses the regulatory issues involved in using biomarkers.

Improve Patient Care and Reduce Costs and Side Effects
Despite the vast amount of literature on biomarkers, there is no comprehensive book that integrates the clinical and statistical components. This book is one of the first to incorporate both the clinical and statistical aspects of biomarkers in the personalized medicine paradigm. Covering a wide spectrum of personalized medicine-related topics, it presents state-of-the-art techniques for advancing the application of biomarkers in drug discovery and development.

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Yes, you can access Clinical and Statistical Considerations in Personalized Medicine by Claudio Carini,Sandeep M Menon,Mark Chang in PDF and/or ePUB format, as well as other popular books in Mathematics & Internal Medicine & Diagnosis. We have over one million books available in our catalogue for you to explore.

Table of contents

  1. Cover Page
  2. Halftitle Page
  3. Series Page
  4. Title Page
  5. Copyright Page
  6. Table of Contents
  7. Preface
  8. Editors
  9. Contributors
  10. 1 Biomarkers for Drug Development: The Time Is Now!
  11. 2 RNAi Screens: Triumphs and Tribulations
  12. 3 Current Advances in Epigenetics
  13. 4 Biomarkers and Precision Medicine: The Case of Rare Diseases
  14. 5 Biomarker-Informed Adaptive Design
  15. 6 Fitting the Dose: Adaptive Staggered Dose Design
  16. 7 Evidence-Based Adaptive Statistical Decision and Design Strategies for Maximizing the Efficiency of Clinical Oncology Development Programs with Predictive Biomarkers
  17. 8 Biomarker Identification in Clinical Trials
  18. 9 Multiplicity in Pharmacogenomics
  19. 10 Patient-Reported Outcomes in Personalized Medicine
  20. 11 Regulatory Issues in Use of Biomarkers in Drug Development