Nanocarriers Based Colon Targeting

Design, Development, Mechanism and Case Studies

Lalit Kumar, Yashwant Pathak

• Publisher: Academic Press
• Year: 2025
• eBook ISBN:
  9780443248078
• Topic: Medicine
• Subtopic: Pharmaceutical, Biotechnology & Healthcare Industry

Nanocarriers Based Colon Targeting: Design, Development, Mechanism and Case Studies unveils a groundbreaking exploration of nanotechnology's potential in revolutionizing drug delivery for colon-related ailments. Today, an array of colonic diseases, including colorectal cancer, colonic polyps, ulcerative colitis, and inflammatory bowel syndrome, pose significant medical challenges. Conventional methods to deliver drugs to this system prove difficult, with limited efficacy and notable side effects. This book delves into the intricate complexities of colonic diseases, their pathophysiology, and epidemiology to support pharmaceutical scientists in designing better drug delivery systems. Providing a comprehensive overview of the area, the chapters elucidate diverse targeting strategies, from time-dependent to microbiota-based drug delivery systems, and explore receptor-based and magnetically assisted delivery mechanisms. Case studies dissected the working mechanisms behind polymeric nanoparticles, polymersomes, polymeric micelles, solid lipid nanoparticles, and other nanocarrier systems tailored for colon targeting. Additionally, this book explores cuttingedge topics such as gold nanoparticles, supra-magnetic iron oxide nanoparticles, and protein–peptide-based nanoparticles, highlighting their mechanisms, applications, and potential toxicities. Merging an overview of colonic pathophysiology with in-depth reviews of each nanomaterial used for drug delivery and practical case studies, Nanocarriers Based Colon Targeting: Design, Development, Mechanism and Case Studies is a complete reference for pharmaceutical scientists involved in elevating drug delivery precision and therapeutic efficacy in this organ system. Toxicologists, material scientists, research physicians, and regulators can also benefit from the case studies developed by expert authors. - Introduces different colonic diseases and their pathophysiology - Explains the mechanism of action of different nanocarriers in colon targeting - Presents case studies of different nanocarriers in colon targeting

Table of contents

• Title of Book
• Chapter 1. An overview on colonic diseases
• Chapter 2. Colonic disease—Targeting strategies
• Chapter 3. Nanocarriers for the colonic diseases
• Chapter 4. Applications of nanocarriers in colon targeting
• Chapter 5. Polymeric nanoparticles in colon targeting
• Chapter 6. Polymersomes in colon targeting
• Chapter 7. Polymeric micelles in colon targeting
• Chapter 8. Solid lipid nanoparticles in colon targeting
• Chapter 9. Nanostructured lipid carriers in colon targeting
• Chapter 10. Liposomes in colon targeting
• Chapter 11. Carbon-based nanomaterials in colon cancer targeting
• Chapter 12. Gold nanoparticles in colon targeting
• Chapter 13. Supramagnetic iron oxide nanoparticles for colon targeting
• Chapter 14. Magnetic triblock copolymer nanoparticles in colon targeting
• Chapter 15. Dendrimer nanoparticles for colon targeting
• Chapter 16. Emerging trends of mesoporous silica nanoparticles in colon targeting
• Chapter 17. Redox nanoparticles in colon drug targeting
• Chapter 18. State of the art application for protein and peptides in colon targeting
• Chapter 19. Hybrid nanoparticles in colon targeting
• Chapter 20. Polysaccharide-based nanocarriers in colon targeting drug delivery system
• Chapter 21. Nanocrystal based approach in colon targeting
• Chapter 22. Nano based enemas for colon targeting
• Chapter 23. Exosomes in colon targeting
• Chapter 24. Nanocarriers in inflammatory bowel disease and colorectal cancer
• Chapter 25. Self nanoemulsifying drug delivery systems in colon targeting
• Chapter 26. Preclinical and clinical status of nanocarriers for colon targeting
• Chapter 27. Regulatory issues and toxicological concerns related to nanocarriers
• Index