Handbook of Traumatic Brain Injury and Neurodegeneration

R.J. Castellani, Rudy J. Castellani

• Publisher: SAGE Publications Ltd
• Year: 2020
• Print ISBN:
  9781643680644
• Edition: 1
• eBook ISBN:
  9781643680651
• Topic: Biological Sciences
• Subtopic: Neuroscience
• Index: Biological Sciences

Holbourne's theory that rotational head movement and shear strains were limiting factors in producing acute parenchymal brain damage was a watershed moment in understanding traumatic brain injury (TBI). Long term effects, and in particular neurodegenerative proteinopathy subsequent to TBI, remain theoretical, notwithstanding the poorly understood 'punch drunk' syndrome of the early and mid-20th century, and the 21st century concept of chronic traumatic encephalopathy. This book, the Handbook of Traumatic Brain Injury and Neurodegeneration, has as its theme the marriage between neurodegenerative disease and neurotrauma through TBI surrogates such as sport, military service, and experimental models, and the legitimacy of that marriage. In the 32 contributions included here, this handbook not only explores the deleterious effects of genuine TBI, but also, and more importantly, the relationship between TBI and neurodegeneration. Controversy notwithstanding, there is much to be learned about the biological effects of TBI, substrates for long-term sequelae, the relationship between TBI and diverse neuropsychiatric disorders, and targets for therapy. The overall message to the neuroscience community from these papers may be a cautionary tale. The null hypothesis, that there is no causal relationship between TBI and progressive neurodegenerative disease, appears to be very much in play, and the book will be of interest to all those working in the field.

Table of contents

• Title Page
• Preface
• Contents
• Long-Term Neurological Consequences Related to Boxing and American Football: A Review of the Literature
• Dementia Pugilistica Revisited
• Assessing the Limitations and Biases in the Current Understanding of Chronic Traumatic Encephalopathy
• The Need to Separate Chronic Traumatic Encephalopathy Neuropathology from Clinical Features
• Tau Biology, Tauopathy, Traumatic Brain Injury, and Diagnostic Challenges
• Chronic Traumatic Encephalopathy and Neurodegeneration in Contact Sports and American Football
• The Neuropathological and Clinical Diagnostic Criteria of Chronic Traumatic Encephalopathy: A Critical Examination in Relation to Other Neurodegenerative Diseases
• No Evidence of Chronic Traumatic Encephalopathy Pathology or Increased Neurodegenerative Proteinopathy in Former Military Service Members
• What is the Relationship of Traumatic Brain Injury to Dementia?
• Brain Injury in the Context of Tauopathies
• Neuropathology in Consecutive Forensic Consultation Cases with a History of Remote Traumatic Brain Injury
• Brain Injury and Later-Life Cognitive Impairment and Neuropathology: The Honolulu-Asia Aging Study
• Head Trauma and Alzheimer's Disease: A Case Report and Review of the Literature
• Traumatic Brain Injury and Risk of Long-Term Brain Changes, Accumulation of Pathological Markers, and Developing Dementia: A Review
• Traumatic Brain Injury and Age of Onset of Dementia with Lewy Bodies
• Prevalence of Traumatic Brain Injury in Early Versus Late-Onset Alzheimer's Disease
• Autonomic Nervous System Dysfunctions as a Basis for a Predictive Model of Risk of Neurological Disorders in Subjects with Prior History of Traumatic Brain Injury: Implications in Alzheimer's Disease
• Self-Reported Traumatic Brain Injury and Mild Cognitive Impairment: Increased Risk and Earlier Age of Diagnosis
• Traumatic Brain Injury and Suicidal Behavior: A Review
• Elevated Plasma MCP-1 Concentration Following Traumatic Brain Injury as a Potential "Predisposition" Factor Associated with an Increased Risk for Subsequent Development of Alzheimer's Disease
• Decreased Level of Olfactory Receptors in Blood Cells Following Traumatic Brain Injury and Potential Association with Tauopathy
• The Influence of the Val66Met Polymorphism of Brain-Derived Neurotrophic Factor on Neurological Function after Traumatic Brain Injury
• Traumatic Brain Injury, Chronic Traumatic Encephalopathy, and Alzheimer's Disease: Common Pathologies Potentiated by Altered Zinc Homeostasis
• Proteomic Profiling of Mouse Brains Exposed to Blast-Induced Mild Traumatic Brain Injury Reveals Changes in Axonal Proteins and Phosphorylated Tau
• Paclitaxel Reduces Brain Injury from Repeated Head Trauma in Mice
• Long-Term Effects of Traumatic Brain Injury in a Mouse Model of Alzheimer's Disease
• VEGF-C Induces Alternative Activation of Microglia to Promote Recovery from Traumatic Brain Injury
• Perfusion Neuroimaging Abnormalities Alone Distinguish National Football League Players from a Healthy Population
• White Matter and Cognition in Traumatic Brain Injury
• MRI Volumetric Quantification in Persons with a History of Traumatic Brain Injury and Cognitive Impairment
• FDDNP-PET Tau Brain Protein Binding Patterns in Military Personnel with Suspected Chronic Traumatic Encephalopathy
• Inflammation in Traumatic Brain Injury
• Subject Index
• Author Index