The Living Laboratory for Precision Medicine

Solutions for Clinical Implementation

Dame Anna Dominiczak, Sandosh Padmanabhan, Carol Clugston

• Publisher: Academic Press
• Year: 2025
• Topic: Biological Sciences
• eBook ISBN:
  9780323953122
• Subtopic: Biology
• Index: Biological Sciences

The Living Laboratory for Precision Medicine: Solutions for Clinical Implementation provides a comprehensive resource on precision medicine through a convergence of innovation and solutions across multiple domains, including large population cohorts, artificial intelligence, genomics, phenomics, clinical trials, health economics and regulation exemplified by the living lab concept. This book is the first to look at precision medicine through the lens of last-mile solutions which make it broad in scope, practically relevant, and cutting-edge. The book explores the use of precision medicine to stimulate regional economic growth through a healthier population, savings on healthcare, and using innovation as a driver of economic development. The term precision medicine has been popularized by clinical, scientific, political, financial and technological interests as the biggest innovation to revolutionize healthcare. While over the past decade a few precision medicine-based solutions have come to fruition, the transformative leap in healthcare delivery and population benefit is yet to be realized. Current focus on precision medicine primarily focuses on patient stratification which constrains it to either a single disease area, a few sub-disciplines, or using a limited set of genomic technologies. While useful, experience over the last few years indicates precision medicine needs to be considered as a complex process with multiple feedback loops requiring significant interdisciplinary collaboration and innovation. - Written by international experts providing a global perspective of innovative and cutting-edge advances that are in both early-development or advanced conceptual stages - Includes real-life case studies that provide practical advice for clinical applications - Presents the living lab concept as a last mile solution for precision medicine

Table of contents

• Title of Book
• Chapter 1. Transforming healthcare through precision medicine
• Chapter 2. The living laboratory for precision medicine—Solutions for the last-mile of implementation of precision medicine
• Chapter 3. Haemato-oncology
• Chapter 4. Pharmacogenomics – challenges and opportunities for precision medicine
• Chapter 5. Medical imaging and artificial intelligence
• Chapter 6. Respiratory medicine
• Chapter 7. Health technology assessment of precision medicine: The living lab approach
• Chapter 8. Harmonising regulatory requirements for validation of digital health technologies in the United States, EU and United Kingdom
• Chapter 9. Data integration in healthcare: Building a legal and ethical framework for precision medicine
• Chapter 10. From concept to reality: Establishing the Digital Health Validation Lab with the triple helix approach
• Index