Retinoic Acids in Cancer Therapy

Mechanisms of Sensitivity, Resistance, and Methods of Delivery

Saeid Ghavami, Ali Zarrabi, Marco Cordani

• Publisher: Academic Press
• Year: 2026
• Topic: Biological Sciences
• eBook ISBN:
  9780443223044
• Subtopic: Biology
• Index: Biological Sciences

Retinoic Acids in Cancer Therapy: Mechanisms of Sensitivity, Resistance, and Methods of Delivery provides an overview of how All-Trans Retinoic Acid (ATRA) kills cancer cells and how some cells survive treatment. Focusing on the cellular pathways and compartments involved in ATRA-mediated inhibition of proliferation, this book also discusses how aggressive tumors develop escape routes conferring retinoic acid resistance.Across 15 chapters, it describes the molecular structure and biological properties of ATRA, explains mechanisms of resistance, and defines ATRA's efficacy in seven cancer types. It concludes with chapters on ATRA and cancer stem cell biology, strategies to improve treatment, future therapeutic perspectives, and delivery methods to reduce toxicity and enhance anticancer efficacy.Each chapter includes Learning Objectives and a "What We Learn" section, making the book highly accessible for undergraduate, graduate trainees, scientists, physicians, and biotech companies. Adding simple, attractive schemes and informative tables makes it ideal for all interested in the current status of Retinoic Acids in Cancer Therapy. This book serves as a valuable resource for health professionals, scientists, researchers, clinical practitioners, and all those seeking to broaden their knowledge and develop new drugs or therapeutic strategies to improve ATRA's efficacy in the treatment of resistant cancers. - Includes Learning Objectives and "What We Learn" sections in every chapter - Presents concise schematic figures illustrating apoptotic and autophagic pathways - Explains the interplay of apoptosis (intrinsic and extrinsic) and autophagy in ATRA-induced cell death - Discusses autophagy targeting to enhance ATRA effectiveness - Examines cancer stem cell fate modulation with ATRA - Highlights future directions and delivery strategies to minimize off-target effects

Table of contents

• Front Cover
• Cancer Sensitizing Agents for Chemotherapy
• Copyright Page
• Cover Image Legend
• Aims and Scope for Series "Cancer Sensitizing Agents for Chemotherapy"
• About the Series Editor
• Aims and Scope of the Volume
• About the Volume Editors
• Preface
• Contents
• List of contributors
• 1 Molecular structure and biological properties of all-trans retinoic acid
• 2 Emerging frontiers in drug development of all-trans retinoic acid and its derivatives
• 3 Cellular and molecular determinants of all trans retinoic acid sensitivity in different cancers
• 4 Apoptosis, autophagy, and unfolded protein response and their impact on all-trans retinoic acid-induced toxicity in cancer cells
• 5 Mechanisms of resistance to all-trans retinoic acid and use of multi-target-directed ligand to fight against resistance
• 6 Nanocarrier systems for targeted delivery of all-trans retinoic acid: design and mechanisms
• 7 Advanced delivery systems for all-trans retinoic acid: challenges and opportunities in pharmacokinetics and bioavailability
• 8 Mechanisms of sensitivity, resistance, and methods of delivery
• 9 Efficiency of all-trans retinoic acid on gastric cancer
• 10 All-trans retinoic acid and its role in glioblastoma therapy
• 11 All-trans retinoic acid and vitamin A in neurodegeneration: from oncology to neuroprotection
• 12 Efficiency of all-trans retinoic acid in liver cancer
• 13 Efficiency of all-trans retinoic acid on colon cancer
• 14 Retinoic acids in head and neck cancer therapy: mechanisms of sensitivity, resistance, and methods of delivery
• 15 Role of artificial intelligence and machine learning in predicting all-trans retinoic acid treatment outcomes
• Index
• Back Cover