Szepietowski JC, Weisshaar E (eds): Itch - Management in Clinical Practice.
Curr Probl Dermatol. Basel, Karger, 2016, vol 50, pp 173-191 (DOI: 10.1159/000446090)
______________________
Itch Management in Childhood
Regina Fƶlster-Holst
Klinik fĆ¼r Dermatologie, Venerologie und Allergologie, UniversitƤtsklinikum Schleswig-Holstein, Kiel, Germany
______________________
Abstract
Itch in children is a very common symptom and is mainly related to a skin disease rather than an underlying systemic disorder. The most common dermatoses include atopic dermatitis, contact dermatitis, insect bites, scabies, and pediculosis capitis. There are specific diagnostic patterns which require the evaluation of a careful history and dermatological examination. For dermatological treatment, we have to consider that children, especially infants, show differences in physiology and pathophysiology, and also in pharmacokinetics and pharmacodynamics compared with adults.
Ā© 2016 S. Karger AG, Basel
Itch (pruritus) is a common symptom in children and therefore it is surprising that there are no data on the prevalence of itch in childhood regarding the general population. After searching for āitch and childrenā and āpruritus and childrenā in PubMed (up to March 9, 2016) there were 2,629 and 2,136 publications, respectively, but in the majority they were related to specific diseases and usually included case reports. Pruritus in childhood is mainly associated with dermatoses. Systemic diseases and drug reactions are rare compared with adults. Itchy dermatoses in childhood include eczematous diseases (especially atopic dermatitis), exanthemas, infestations/infections, urticaria/mastocytosis, autoimmune diseases, as well as genodermatoses. For dermatologic treatment (topical and systemic), we have to consider special features in childhood regarding physiology and pathophysiology, and also pharmacokinetics and pharmacodynamics, which differ from those of adults.
Special Features of Skin Physiology, Pathophysiology, and Skin Care of Early Childhood That Should Be Considered in Treatment
We have to consider special features regarding skin physiology and pathophysiology in childhood, mainly in young infants. The high ratio of body surface to body weight [1] determines the absorption of topically applied drugs and emollients. In addition, the skin of infancy is characterized by a thinner epidermis and stratum corneum, and also by smaller corneocytes [1, 2]. Physical measurements of the epidermal barrier function show that natural moisturizing factors and surface lipid concentrations of infant skin are reduced compared with adults. In addition there are high pH, high desquamation, high proliferation rates, and higher transepidermal water loss [3]. These findings lead to impaired epidermal structure and function, resulting in high absorption of topically applied drugs and high penetration of environmental factors such as irritants, allergens, and infectious agents [4]. We should consider these facts in the treatment of infants in general, and especially in those infants who suffer from diseases with a known barrier defect as atopic dermatitis [5]. However, besides the properties of the skin barrier, the percutaneous absorption of drugs and topical agents of the emollients is related to the physical and chemical characteristics of the drug [6]. Emollients in early childhood should be free of perfumes, dyes, and preservatives, which are known for their risk of irritation and allergenicity. Although emollients do not have antipruritic properties in general, they lubricate and moisturize the skin, protect the integrity of the stratum corneum and of the skin barrier, and treat dry skin [7]. There are studies that have shown relief of itching using emollients [8, 9].
Special Features of History, Dermatological Examination, and Diagnoses in Childhood
Medical care in childhood is in many ways different from that in adulthood. To get reasonable statements during the anamnesis, adequate contact to both child and parents is necessary. When the children are of preschool/school age, the questions should be addressed to both the parents and the children, including regarding itch. The dialogue between the patient and the doctor is the basis of a good bond of trust [4]. This also determines the adherence to treatment [4].
Anamnesis regarding questions for itch in children do not differ so much from those in adults. However, there are special issues to consider in this phase of life, including contact with other children, clothing, and vaccinations within the regular pediatric control examinations, everyday activities, and eating habits. When taking the history for itch in childhood, the following questions and examinations are helpful:
ā¢ Is the itch localized (regional infection, localized dermatosis) or generalized (symmetrical distribution in relation to generalized dermatosis or systemic disease)?
ā¢ Do other family members also suffer from itch?
ā¢ Is there a history of known diseases and/or allergies of the child and/or other family members (e.g. atopic diseases)?
ā¢ When did the sensation of itch begin and how is the quality of itch?
ā¢ Does the family have pets at home? In which environment does the child live?
ā¢ Is the child in a good general condition?
ā¢ Are there foods which are related to pruritus?
ā¢ Is there an infection related to pruritus?
ā¢ Is there emotional stress or a history of psychiatric disease?
ā¢ What products do the child/parents use for skin care? What are the childās bathing habits (frequency per week, temperature, duration, etc.)?
ā¢ Does the child take drugs? If yes, which drugs, for which indication, how long already?
ā¢ Which clothes does the child wear (cotton, silk, wool, others)?
ā¢ Are there infections around (kindergarten, school, etc.)?
The clinical examination of the child differs from that of adults. This includes not only being able communicate on the childās level, which requires inter alia a different language, but also the assessment of itch by the child. In the literature there are some itch assessment scales, which may be used in childhood, for example the itch assessment scale for the Pediatric Burn Survivor [10]. This āitch man scaleā correlates with other scales, for example the 5D itch scale and the visual analogue scale.
Table 1. Itchy eczematous diseases (selection)
Diseases | Clinical pattern | Age of onset |
Dermatitis | | |
Atopic dermatitis | eczema of the extremity folds, associated with asthma, allergic rhinitis, and food allergy | mainly in the first year of life |
Contact dermatitis | eczema at the sites of contact | anytime |
Seborrheic dermatitis in infancy | eczema of axillary, groins, and diaper area | in the first weeks of life |
Infestations Scabies (infantile) | burrows, disseminated eczema (including face and head), pustules plantar
| anytime
|
Pediculosis capitis | papules, pustules, eczema of head and neck | mainly in school age |
Genodermatose... |