Nitric Oxide and the Cell

Proliferation, Differentiation, and Death

S. Moncada, G. Nisticò, G. Bagetta, E. A. Higgs, S. Moncada, G. Nisticò, G. Bagetta, E. A. Higgs, S. Moncada, G. Nisticò, G. Bagetta, E. Higgs

• Publisher: Princeton University Press
• Year: 2017
• Print ISBN:
  9780691600901
  9780691007168
• eBook ISBN:
  9781400887538
• Topic: Biological Sciences
• Subtopic: Biochemistry
• Index: Biological Sciences

Nitric oxide has proven to be a molecule with wide biological significance. It is involved in myriad actions which range from physiology to pathophysiology. One of the fundamental questions in relation to its biological relevance concerns the paradoxical nature of some of its actions. For example, there is a whole range of effects related to cytoprotection, cell proliferation, differentiation, and cell death. The way in which nitric oxide becomes involved in pathophysiology is slowly being elucidated. This volume contains a summary of the discussions that took place at the Second International Paraelios Symposium on Nitric Oxide research, and will make a significant contribution to this very exciting subject.

Originally published in 1998.

The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.

Table of contents

• Cover
• Title Page
• Copyright
• Contents
• Preface
• Contributors
• Abbreviations
• 1. Nitric oxide, mitochondria and cytotoxicity
• 2. Nitric oxide and its congeners in mitochondria: implications for apoptosis
• 3. Interactions between nitric oxide and cytochrome-c oxidase in turnover
• 4. Nitric oxide interactions with mitochondria and oxygen metabolism
• 5. Resistance factors for nitorsative and oxidative stress
• 6. S-Nitrosylation of thiol groups in haemoglobins from various species
• 7. Differential inhibitory action of nitric oxide and peroxynititre on the R2 subunit of ribonucleotide reductase
• 8. Hydroxyguanidines as modifiers of cell proliferation and death: a possible role for nitric oxide
• 9. Control of cell growth by nitric oxide: the role of cGMP-dependent and -independent events occuring at various steps of growth factor-activated signalling processes
• 10. Nitric oxide controls cell proliferation during Drosophila development
• 11. Cytoprotective actions of nitric oxide in hepatic inflammation
• 12. Activation of nuclear factor-kB and activator protein-I, and steady-state level of mRNA encoding tumour necrosis factor-a and inducible nitric oxide synthase in rate liver during different types of cell proliferation
• 13. The mechanism of nitric oxide-induced apoptosis in the pancreatic B-cell may involve cGMP and protein kinase G
• 14. Normal and pathological expression of nitric oxide synthase in the central nervous system
• 15. The role of astroglial cell-derived nitric oxide and prostanoids in death and repair mechanisms in the brain
• 16. Role of nitric oxide and nerve growth factor in the mechanisms of neurotoxicity induced by the HIV-I coat protein gp 120 in rat
• 17. Mechanisms of neurotoxicity induced by the HIV-I coat protein, gp 120, in human neuroblastoma cells in culture
• 18. Nitric oxide mediates differentiation and survival of neuronal cells
• 19. Neuromodulatory and neuroprotective actions of nitric oxide in the striatum
• 20. Microdialysis study in vivo of the nitric oxide/cGMP pathway in the hippocampus and cerebellum of adult and aged rats
• 21. Mechanisms of neuronal apoptosis elicited by glutamate or nitric oxide donors
• 22. Evidence that nitric oxide induces apoptotic cell death in the lateral geniculate nucleus of dark-reared rabbits
• 23. Nitric oxide and prostaglandins in inflammation
• 24. A further insight into mechanism of lipoxygenase inhibition by nitric oxide
• 25. The role of nitric oxide in T-cell functions
• 26. CD95-induced calcium release and apoptosis are regulated by nitric oxide via a cGMP-dependent pathway in human yg T-lymphocytes
• 27. Nitric oxide-initiated apoptotic cell death: activating and antagonistic signalling components
• 28. Nitric oxide-induced apoptosis of RAW264.7 peritoneal macrophages: relationship between apoptosis and integrin expression profiles
• 29. Nitric oxide, p53 and cancer
• 30. The role of nitric oxide in Bacillus Calmette-Guerin-mediated anti-tumour effects in human bladder cancer
• 31. Nitric oxide priming inhibits nitric oxide-mediated apoptosis
• Subject Index