2-Oxoglutarate-Dependent Oxygenases
eBook - PDF

2-Oxoglutarate-Dependent Oxygenases

  1. 487 pages
  2. English
  3. PDF
  4. Available on iOS & Android
eBook - PDF

2-Oxoglutarate-Dependent Oxygenases

About this book

Since the discovery of the first examples of 2-oxoglutarate-dependent oxygenase-catalysed reactions in the 1960s, a remarkably broad diversity of alternate reactions and substrates has been revealed, and extensive advances have been achieved in our understanding of the structures and catalytic mechanisms. These enzymes are important agrochemical targets and are being pursued as therapeutic targets for a wide range of diseases including cancer and anemia.
This book provides a central source of information that summarizes the key features of the essential group of 2-oxoglutarate-dependent dioxygenases and related enzymes. Given the numerous recent advances and biomedical interest in the field, this book aims to unite the latest research for those already working in the field as well as to provide an introduction for those newly approaching the topic, and for those interested in translating the basic science into medicinal and agricultural benefits.
The book begins with four broad chapters that highlight critical aspects, including an overview of possible catalytic reactions, structures and mechanisms. The following seventeen chapters focus on carefully selected topics, each written by leading experts in the area. Readers will find explanations of rapidly evolving research, from the chemistry of isopenicillin N synthase to the oxidation mechanism of 5-methylcytosine in DNA by ten-eleven-translocase oxygenases.

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Yes, you can access 2-Oxoglutarate-Dependent Oxygenases by Christopher Schofield, Robert Hausinger in PDF and/or ePUB format, as well as other popular books in Physical Sciences & Biochemistry. We have over one million books available in our catalogue for you to explore.

Information

Publisher
Royal Society of Chemistry
Year
2015
eBook ISBN
9781782621959
Edition
1
Topic
Physical Sciences
Subtopic
Biochemistry

Table of contents

  1. Cover
  2. Preface
  3. Contents
  4. Chapter 1 Biochemical Diversity of 2-Oxoglutarate-Dependent Oxygenases
  5. Chapter 2 Introduction to Structural Studies on 2-Oxoglutarate- Dependent Oxygenases and Related Enzymes
  6. Chapter 3 Mechanisms of 2-Oxoglutarate-Dependent Oxygenases: The Hydroxylation Paradigm and Beyond
  7. Chapter 4 Synthetic Models of 2-Oxoglutarate-Dependent Oxygenases
  8. Chapter 5 Collagen Hydroxylases
  9. Chpater 6 The Role of 2-Oxoglutarate-Dependent Oxygenases in Hypoxia Sensing
  10. Chapter 7 JmjC Lysine Demethylases
  11. Chapter 8 AlkB and Its Homologues – DNA Repair and Beyond
  12. Chapter 9 RNA Demethylation by FTO and ALKBH5
  13. Chapter 10 Role of ALKBH8 in the Synthesis of Wobble Uridine Modifications in tRNA
  14. Chapter 11 The TET/JBP Family of Nucleic Acid Base-Modifying 2-Oxoglutarate and Iron-Dependent Dioxygenases
  15. Chapter 12 2-Oxoglutarate-Dependent Hydroxylases Involved in DNA Base J (β-DGlucopyranosyloxymethyluracil) Synthesis
  16. Chapter 13 Dioxygenases of Carnitine Biosynthesis: 6-N-Trimethyllysine and γ-Butyrobetaine Hydroxylases
  17. Chapter 14 Phytanoyl-CoA Hydroxylase: A 2-Oxoglutarate-Dependent Dioxygenase Crucial for Fatty Acid Alpha-Oxidation in Humans
  18. Chapter 15 Role of 2-Oxoglutarate-Dependent Oxygenases in Flavonoid Metabolism
  19. Chapter 16 Gibberellin Metabolism
  20. Chapter 17 2-Oxoglutarate-Dependent Oxygenases of Cephalosporin Synthesis
  21. Chapter 18 Recent Advances in the Structural and Mechanistic Biology of Non-Haem Fe(ii), 2-Oxoglutarate and O2-Dependent Halogenases
  22. Chapter 19 Isopenicillin N Synthase
  23. Chapter 20 1-Aminocyclopropane-1-Carboxylic Acid Oxidase†
  24. Chpater 21 4-Hydroxyphenylpyruvate Dioxygenase and Hydroxymandelate Synthase: 2-Oxo Acid-Dependent Oxygenases of Importance to Agriculture and Medicine
  25. Subject Index