Drug Hypersensitivity
eBook - PDF

Drug Hypersensitivity

  1. English
  2. PDF
  3. Available on iOS & Android
eBook - PDF

Drug Hypersensitivity

About this book

A Karger 'Publishing Highlights 1890–2015' title Drug hypersensitivities are immune-mediated reactions characterized by exanthems, fever and internal organ involvement. They represent a challenging field of research: many different drugs can induce a variety of clinical symptoms through multiple mechanisms of drug-host interaction, many of which are poorly understood. This is the first book to approach the phenomenon of drug hypersensitivity in a comprehensive manner. Besides epidemiological aspects, it addresses the immunological mechanisms underlying these complicated reactions which go far beyond the IgE-mediated drug allergies also considered in the book. Furthermore, the book covers clinical manifestations and new diagnostic methods, and introduces some recently established animal models. Well-accepted and also completely new concepts are presented and discussed in detail. Many topics are treated from multiple perspectives, and the 33 chapters are thoroughly cross-referenced. This publication will be of immense value not only to allergologists, dermatologists and anyone prescribing medication, but also to scientists in a pharmaceutical industry challenged by the economic effects of failures in drug development or drug removal from the market. Elucidating the mechanisms of drug hypersensitivity will not only help to identify patients at risk but will also provide novel insights into the pathophysiology of numerous immune-mediated diseases.

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Yes, you can access Drug Hypersensitivity by W. J. Pichler, Pichler in PDF and/or ePUB format, as well as other popular books in Medicine & Dermatology. We have over one million books available in our catalogue for you to explore.

Information

Publisher
S. Karger
Year
2007
Print ISBN
9783805582698
eBook ISBN
9783318014549
Edition
1
Topic
Medicine
Subtopic
Dermatology

Table of contents

  1. Cover
  2. Contents
  3. Foreword
  4. Epidemiology and Causes of Drug Hypersensitivity
  5. Epidemiology and Causes of Severe Cutaneous Adverse Reactions to Drugs
  6. Chemical-Induced Contact Hypersensitivity in the Mouse Model
  7. Lessons from Nickel Hypersensitivity: Structural Findings
  8. Drugs as Haptens, Antigens, and Immunogens
  9. The p-i Concept: Evidence and Implications
  10. Tolerance Mechanisms to Small Molecular Compounds
  11. HIV and Drug Hypersensitivity
  12. Abacavir Hypersensitivity
  13. Genetics of Severe Drug Hypersensitivity Reactions in Han Chinese
  14. Nevirapine Hypersensitivity
  15. Animal Models of Toxic Epidermal Necrolysis
  16. Non-Clinical Testing Approaches for Drug Development: Possibilities and Limitations
  17. Adverse Side Effects to Biological Agents
  18. Drug Hypersensitivity Reactions: Classification and Relationship to T-Cell Activation
  19. Urticaria and Anaphylaxis due to Betalactams ( Penicillins and Cephalosporins)
  20. Perioperative Anaphylaxis
  21. IgE-Mediated Allergy to Pyrazolones, Quinolones and Other Non-Beta-Lactam Antibiotics
  22. Hypersensitivity Reactions to Iodinated Contrast Media: An Update
  23. Maculopapular Drug Eruptions
  24. Drug-Induced Hypersensitivity Syndrome and Viral Reactivation
  25. Clinic and Pathogenesis of Severe Bullous Skin Reactions: Stevens- Johnson Syndrome, Toxic Epidermal Necrolysis
  26. Drug Allergic Liver Injury
  27. Drug-Induced Interstitial Nephritis
  28. Blood Dyscrasias Caused by Hypersensitivity to Drugs
  29. Allergy and Pseudoallergy to Drugs and Vaccines in Children
  30. Hypersensitivity to Aspirin and Other NSAIDs: Mechanisms, Clinical Presentation and Management
  31. Approach to the Patient with a Drug Hypersensitivity Reaction – Clinical Perspectives
  32. Place of Drug Skin Tests in Investigating Systemic Cutaneous Drug Reactions
  33. In vitro Tests of T-Cell- Mediated Drug Hypersensitivity
  34. In vitro Tests: Basophil Activation Tests
  35. Desensitization with Antibiotics
  36. Drug Desensitization in Oncology: Chemotherapy Agents and Monoclonal Antibodies
  37. Author Index
  38. Subject Index
  39. Cover