Diabetes and Cancer

Epidemiological Evidence and Molecular Links

K. Masur, F. Thévenod, K. S. Zänker, Massimo Porta

• Publisher: S. Karger
• Year: 2008
• Print ISBN:
  9783805586405
• eBook ISBN:
  9783805586412
• Edition: 1
• Topic: Medicine
• Subtopic: Nutrition, Dietics & Bariatrics

The interdisciplinary work revealing varied roles in biological processes of chronic diseases has led to a new field of research concerning common molecular and clinical features of chronic diseases. Epidemiological literature suggests an association between the history of metabolic syndrome/diabetes mellitus type 2 and the risk of developing a variety of cancers. This book, at the forefront of experimental and clinical research, is the first to highlight the common molecular links between these two diseases. These tight links indicate a complex interdependency between both diseases on a cellular and hormonal basis, which is influenced by a variety of aspects (e.g. nutritional, social and neuro-immunological factors). Special attention has been given to the fundamental role of the switch from oxidative phosphorylation to glycolysis of cancer cells - the Warburg effect. Offering insights into the interdisciplinary approaches of tomorrow, this publication will encourage endocrinologists, oncologists, diabetologists, general practitioners, diabetic nurses and students of life sciences working separately on various aspects of diabetes and cancer to come together and combine therapies and strategies.

Table of contents

• Cover
• Contents
• Preface
• Pathophysiology of Diabetes Mellitus Type 2: Roles of Obesity, Insulin Resistance and Beta-Cell Dysfunction
• In vivo Beta-Cell Imaging in Diabetes, Beta-Cell Hyperplasia, and Insulinoma
• Incretin-Based Therapies for the Treatment of Type 2 Diabetes – DPP-4 Inhibitors and Incretin Mimetics
• Janus Face of Glucose and Glucose-Regulating Hormones
• Role of Glucose Metabolism in Carcinogenesis and Cancer Progression
• Glucose Transporters: Their Abnormalities and Significance in Type 2 Diabetes and Cancer
• The Epidemiologic Relationship between Diabetes and Cancer
• Diabetes Mellitus and Breast Cancer
• Nutrition, Diabetes, and Cancer
• Diabetes and Cancer: The Road Ahead
• Subject Index