Kinase Drug Discovery
eBook - PDF

Kinase Drug Discovery

Modern Approaches

  1. 414 pages
  2. English
  3. PDF
  4. Available on iOS & Android
eBook - PDF

Kinase Drug Discovery

Modern Approaches

About this book

Kinase inhibition remains an area of significant interest, and growing importance, across academia and the pharmaceutical industry. There are now many marketed drugs that target kinases and a significant number of compounds are currently in various stages of clinical development. This book is a forward-looking analysis of a number of key areas for kinase inhibition in the coming years and builds on the first volume. This includes topics such as screening approaches to target kinases along with different modes of inhibition such as allosteric and covalent. Novel approaches such as macrocyclisation are considered along with how the properties of kinase inhibitors have evolved, including the potential for brain penetration. Recent areas of great importance also covered include cutting edge molecular modelling approaches and the importance of kinase mutations. The evolving biology of kinases has also resulted in increased interest in the immuno-oncology area and also pseudokinases as a target family. As with the first volume the book finishes with a forward looking view of how research against this fascinating target class may evolve.

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Yes, you can access Kinase Drug Discovery by Richard A Ward, Frederick W Goldberg in PDF and/or ePUB format, as well as other popular books in Biological Sciences & Biochemistry. We have over one million books available in our catalogue for you to explore.

Table of contents

  1. Cover
  2. Kinase Drug Discovery: Modern Approaches
  3. About the Editors
  4. Contents
  5. Chapter 1 - Introduction to Kinase Drug Discovery – Modern Approaches
  6. Chapter 2 - New Screening Approaches for Kinases
  7. Chapter 3 - The Screening and Design of Allosteric Kinase Inhibitors
  8. Chapter 4 - Covalent Inhibition of Kinases
  9. Chapter 5 - Small Molecule Macrocyclic Kinase Inhibitors
  10. Chapter 6 - The Design of Brain Penetrant Kinase Inhibitors
  11. Chapter 7 - Cutting Edge Approaches to Structure-based Computational Modelling of Kinases
  12. Chapter 8 - The Properties of Kinase Inhibitors
  13. Chapter 9 - Assessment and Optimisation of Kinase Inhibitor Selectivity to Achieve Candidates with an Appropriate Safety Profile
  14. Chapter 10 - Drugging the Kinome
  15. Chapter 11 - The Importance of Kinase Mutations in Cancer Drug Discovery
  16. Chapter 12 - Kinase Inhibition for Immuno-oncology
  17. Chapter 13 - A Structural Perspective of the Pseudokinome: Defining the Targetable Space
  18. Chapter 14 - The Future of Kinase Therapeutics
  19. Subject Index