Tumor Hypoxia
eBook - ePub

Tumor Hypoxia

  1. 320 pages
  2. English
  3. ePUB (mobile friendly)
  4. Available on iOS & Android
eBook - ePub

Tumor Hypoxia

About this book

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Tumors often start out as a benign growth, but gradually progress toward the malignant stage over a relatively long period of time. Tumor progression results from accumulated genetic mutations and inheritable epigenetic modifications that enable clonal evolution and selection of new clonal populations of tumor cells with aggressive characteristics including metastasis and therapy resistance. Increasing amounts of experimental evidence suggests that tumor microenvironment play a significant role in directing clonal evolution and determining clonal cell fate, which eventually leads to emergence of malignant tumor cell clones. Hypoxia is the most commonly observed feature of tumor microenvironment. Tumor hypoxia is significantly associated with malignant progression and predicts poor patient outcomes. This book provides detailed and up-to-date treaties on the role of hypoxia as a major driving force in tumor microenvironment to elicit cellular adaptation and clonal selection via genetic mutations and epigenetic modifications, to facilitate cancer stem cell maintenance, to enhance metastasis, to augment therapy resistance, and to evade immune surveillance.

--> Editor Yun Zhong 0Tumor Biology, Cancer Biology, Tumor Hypoxia, Oncology, Tumor Microenvironment

  • Emerging areas of research: cancer stem cells, epigenetics, immune modulations, post-translational modifications of HIF, cancer metabolism
  • Comprehensive discussion of clinical impact as well as new mechanistic paradigms
  • Internationally renowned leaders in the field of hypoxia, tumor microenvironment, and cancer biology: Giaccia, Glazer, Pahlman, and Li

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Yes, you can access Tumor Hypoxia by Yun Zhong in PDF and/or ePUB format, as well as other popular books in Medicina & Oncologia. We have over one million books available in our catalogue for you to explore.

Information

Publisher
WSPC
Year
2016
eBook ISBN
9789813147331
Topic
Medicina
Subtopic
Oncologia

Index

A
aberrant DNA synthesis, 171
replicon misfiring, 171
acetylates, 55
acetylation, 54
acidosis, 226
action, 11
adaptive immunity, 80
adaptive responses, 235
adenosine, 263, 275
adult stem cell, 102
adverse prognosis, 207
aerobic, 2, 9–10, 14–16, 32
aggressive phenotypes, 169
aHIF, 196
AIFM3, 202
amino acid metabolism, 231
AML, 103
amyotrophic lateral sclerosis (ALS), 237
angiogenesis, 50, 57, 59, 81, 84, 90, 204–205, 234, 250, 252, 254
leaky vessels, 84
angiopoietin 2, 85
anoikis, 78–79
ERBB2, 79
anoxia, 233
anoxic, 3, 5–8, 10, 14, 16, 32–33
anti-angiogenic factors, 85
anti-oxidant responses, 231
anti-tumor immunity, viii
apoptosis, 131–132, 134–135, 142–143, 202, 226, 252–253, 266
arginine, 254, 256, 261
arrest-defective-1 (ARD1), 54–55
aryl hydrocarbon receptor nuclear translocator (ARNT), 251, 269
ataxia telangiectasia and Rad3-related (ATR), 172–173
ataxia telangiectasia mutated
ATM, 173
ATF6, 227
autophagosome, 236
autophagy, 131–132, 134, 142, 231
autophosphorylation, 229
B
basement membrane, 71, 73
BCL2, 203
Bcl-2-homology domain 3 (BH-3)-only family protein, 79
benzotriazine di-N-oxides, 22
Bevacizumab, 90
biological effect, 7, 19, 27
biological target volume (BTV), 23
biomarker, 208–209
biophysical models, 31, 33
bioreductive drugs, 12
BIX, 239
BNIP3, 79
bone marrow, 104
bone ...

Table of contents

  1. Cover
  2. Title
  3. Copyright
  4. Preface
  5. Contents
  6. Tumor Hypoxia and Radiotherapy
  7. Post-translational Modifications of the Hypoxia Inducible Factors
  8. Hypoxia and Metastasis
  9. Hypoxia and Cancer Stem Cell Regulation
  10. Hypoxia and Senescence
  11. Hypoxic Reprograming of Tumor Metabolism, Matching Environmental Supply with Biosynthetic Demand
  12. Regulation of DNA Repair by Hypoxia
  13. Regulation of the Hypoxic Response by Non-coding RNAs
  14. Hypoxia-Induced Endoplasmic Reticulum Stress
  15. The Hypoxic Tumor Microenvironment and the Anti-cancer Immune Response
  16. Index