The blood memory
Assessment of the chronic myeloproliferative disorders in patients with CML mutations Philadelphia chromosome BCR/ABL1
Shahin Asadi, Mina Niknia
- 216 páginas
- English
- PDF
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The blood memory
Assessment of the chronic myeloproliferative disorders in patients with CML mutations Philadelphia chromosome BCR/ABL1
Shahin Asadi, Mina Niknia
Información del libro
Today the hematological infectious diseases are very important. Dangerous and life-threatening human diseases, such as CML Lukemia is also very important and must do more research Catch. Unfortunately routes now there is no cure for the disease, CML Lukemia, and every year the number of deaths the disease will increase. Genetic studies in the future we hope to be able to cure this disease is very dangerous. In this book, we looked at mutations in chromosomes 9 and 22 and how to switch genes BCR and ABL1 in creating the Philadelphia chromosome, were analyzed.Chronic myeloproliferative disorders (MPDs) are a heterogeneous group of diseases in which a clonal disorder of hematopoietic stem cells leads to an increase in the level of production in one or more of the blood cell. CML Lukemia recently acquired mutations in many patients with chronic myeloproliferative disorders (MPDs) is described by changing G to T mutation at nucleotide 1849 in exon 12 of the JAK2 gene is located on chromosome 9 identified, which leads to substitution of the amino acid phenylalanine instead of valine at position 617 of the protein JAK2.