Principles of Virology, Volume 2
Pathogenesis and Control
S. Jane Flint, Vincent R. Racaniello, Glenn F. Rall, Theodora Hatziioannou, Anna Marie Skalka
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Principles of Virology, Volume 2
Pathogenesis and Control
S. Jane Flint, Vincent R. Racaniello, Glenn F. Rall, Theodora Hatziioannou, Anna Marie Skalka
Informazioni sul libro
Principles of Virology, the leading virology textbook in use, is an extremely valuable and highly informative presentation of virology at the interface of modern cell biology and immunology. This text utilizes a uniquely rational approach by highlighting common principles and processes across all viruses. Using a set of representative viruses to illustrate the breadth of viral complexity, students are able to under-stand viral reproduction and pathogenesis and are equipped with the necessary tools for future encounters with new or understudied viruses. This fifth edition was updated to keep pace with the ever-changing field of virology. In addition to the beloved full-color illustrations, video interviews with leading scientists, movies, and links to exciting blogposts on relevant topics, this edition includes study questions and active learning puzzles in each chapter, as well as short descriptions regarding the key messages of references of special interest. Volume I: Molecular Biology focuses on the molecular processes of viral reproduction, from entry through release. Volume II: Pathogenesis and Control addresses the interplay between viruses and their host organisms, on both the micro- and macroscale, including chapters on public health, the immune response, vaccines and other antiviral strategies, viral evolution, and a brand new chapter on the therapeutic uses of viruses. These two volumes can be used for separate courses or together in a single course. Each includes a unique appendix, glossary, and links to internet resources. Principles of Virology, Fifth Edition, is ideal for teaching the strategies by which all viruses reproduce, spread within a host, and are maintained within populations. This edition carefully reflects the results of extensive vetting and feedback received from course instructors and students, making this renowned textbook even more appropriate for undergraduate and graduate courses in virology, microbiology, and infectious diseases.
Domande frequenti
Informazioni
1 Infections of Populations: History and Epidemiology
- Introduction to Viral Pathogenesis
- A Brief History of Viral Pathogenesis
- The Relationships among Microbes and the Diseases They Cause
- The First Human Viruses Identified and the Role of Serendipity
- New Methods Facilitate the Study of Viruses as Causes of Disease
- Viral Epidemics in History
- Epidemics Shaped History: the 1793 Yellow Fever Epidemic in Philadelphia
- Tracking Epidemics by Sequencing: West Nile Virus Spread to the Western Hemisphere
- Zoonotic Infections and Epidemics Caused by “New” Viruses
- The Economic Toll of Viral Epidemics in Livestock
- Population Density and World Travel Are Accelerators of Viral Transmission
- Focus on Frontline Health Care: Ebolavirus in Africa
- Emergence of a Birth Defect Associated with Infection: Zika Virus in Brazil
- Epidemiology
- Fundamental Concepts
- Methods Used by Epidemiologists
- Surveillance
- Network Theory and Practical Applications
- Parameters That Govern the Ability of a Virus to Infect a Population
- Geography and Population Density
- Climate
- Perspectives
- References
- Study Questions
LINKS FOR CHAPTER 1
- Video: Interview with Dr. W. Thomas London http://bit.ly/Virology_London
- Epidemiology causes conclusions (p less than 0.01) http://bit.ly/Virology_Twiv169
- Slow motion sneezing http://bit.ly/Virology_1-23-13
- CD4 Hunter http://bit.ly/Virology_Twiv489
Introduction to Viral Pathogenesis
PRINCIPLES Introduction to viral pathogenesis
- Diseases associated with viral infections are a collateral outcome of the parasitic nature of these pathogens.
- Koch’s postulates helped to identify causal relationships between a microbe and the disease it causes in the host, although these postulates may not be fulfilled when associating some viruses with a particular disease.
- Major insights in viral pathogenesis have come from exploitation of technical advances in the fields of molecular biology and immunology.
- The increased mobility of human and animal populations on the planet has accelerated the emergence of epidemics.
- Many viruses that can infect multiple species establish a reservoir in an animal host in which the virus causes negligible disease. Spread into new human hosts, called a zoonosis, is usually a dead-end infection.
- Epidemiology, the study of infections in populations, is the cornerstone of public health research and response.
- Individual differences among prospective hosts, group dynamics and behaviors, geography, and climate all influence how efficiently a virus can establish infection within a population.
- The regional occurrence of viral infections may be due to the restriction of a vector or animal reservoir to a limited geographical area.
- Seasonal differences in the appearances of some viruses may be due to variations in viral particle sta...