The Theory of Endobiogeny

Volume 3: Advanced Concepts for the Treatment of Complex Clinical Conditions

Kamyar M. Hedayat, Jean-Claude Lapraz

• Editore: Academic Press
• Anno: 2019
• ISBN:
  9780128173329
• Argomento: Biological Sciences
• Categoria: Biology

Theory of Endobiogeny, Volume 3: Advanced Concepts for Treatment of Complex Clinical Conditions explains complex and multi-factorial disorders and diseases using the theory of endobiogeny. It provides detailed applications of biological modeling, in-depth assessment into common disorders, an endobiogenic analysis, guidance on using biological modeling tools, and suggestions for treatment using standard of care treatments that also take into account diet, lifestyle and medicinal plants. This approach is an evolution in thinking from reductionism to holism, offering advice for symptomatic treatments that can be used in conjunction with a new way of thinking about diseases and disease management.

• Covers complex and multi-factorial disorders and diseases using the theory of endobiogeny
• Provides detailed applications of biological modeling that can be used within current clinical practice
• Extends systems biology from the cell level to the physiology level using pattern recognition

Chapter 1

Allergic disorders

Abstract

There are two types of disorders related to hyperfunctioning of the immune system: allergic and autoimmune. They can be divided into four types based on the elements of adaptive and/or innate immunity involved. This chapter presents a general overview of allergic disorders. The expression of allergies in certain parts of the body depends on two factors. The first is the autopathogenic endocrine axis. For example, if it is the gonadotropic axis, there is a risk of dermal atopy. The second is the organ or tissues with the greatest metabolic activity. This can be structural, such as a joint, into which immune complexes can deposit, or it can be metabolic or emunctory, such as the lungs. The remainder of the chapter focuses on eczema as an exemplary expression of type 1, IgE mediated allergy. The precritical terrain of eczema is (1) hyperimmunity, (2) spasmophilia, (3) adrenal cortex tendency toward permissive and anabolic activity, and (4) hepatobiliary-intestinal congestion. The critical terrain involves insufficient cortisol and overfunctioning of the thyrotropic axis. The terrain of the four stages of eczema evolution is discussed, along with the neuroendocrine origin of the topology of eczema. The chapter concludes with two case studies illustrating the evaluation and treatment of eczema in an infant and adolescent.

Keywords

Adaptive immunity; Adrenocorticotropic hormone (ACTH); Allergic disorder; Antihistamine therapy; Eczema; Endobiogeny; Endocrinology; Endoderm; Food allergies; Histamine; Immunoglobulin E (IgE); Innate immunity; Thyrotropin-releasing hormone (TRH)

Introduction

The immune system is key to the survival of the organism. It is responsible for recognizing self vs nonself. Vigilance and defense are preferred to attack (The Theory of Endobiogeny, Volume 2, Chapter 3). When the immune system is hyperfunctioning, it is at risk of favoring attack over other roles. Allergies and autoimmune diseases are both disorders of immune hyperfunctioning. Because of the rising prevalence of these disorders around the world, understanding the underlying Endobiogenic terrain allows for the approach to therapy to be restorative and even curative, rather than merely suppressive.

The immune system is engaged in a triadic relationship with the autonomic nervous system and endocrine system. The corticotropic and thyrotropic axes are most implicated. The less competent one aspect of the triad is that the greater the other branches will be in compensation. In allergic disorders, the adrenal cortex is incompetent in its response to aggression, producing more anabolic steroids related to cortisol, and creating a more permissive terrain related to an adaptive one. To compensate, the ANS, thyrotropic axis and immune system become more active, leading to hyperimmunity. Therefore, most simply, allergies are a hyperimmune response to an agent that has contacted the body.

Allergies pose a particular challenge for the physician. The incidence of allergic disorders has increased considerably.¹ In a 10-year period, food allergies in children increased fivefold. Skin allergies have increased 2.5-fold. The approach of preventative medicine and social work has been to reduce exposure to allergens. The assumption is that allergens are bad and must be reduced or eliminated. An allerge...