Scritto prima che l'LSD diventasse illegale, questa raccolta uscì nel 1964, quando a occuparsi dell'acido lisergico erano accademici, psichiatri e chimici, e ben prima che scoppiassero negli Stati Uniti reazioni furibonde da parte dei benpensanti e dell'ortodossia scientifica. Frutto delle ricerche di scienziati, filosofi e scrittori di fama internazionale (Aldous Huxley, Timothy Leary e William S. Burroughs, solo per citarne alcuni), che sperimentarono su loro stessi gli effetti di questo potente allucinogeno, l'LSD viene presentato come possibile arma di difesa spirituale per sopravvivere all'alienazione della società e come mezzo per poter esplorare terreni sconosciuti del nostro pensiero, quali il sogno e la fantasia, ma ne vengono indagate anche le potenzialità terapeutiche (ad esempio la cura delle malattie mentali e dell'alcolismo), mettendo nondimeno in guardia contro i reali pericoli inerenti al suo uso indiscriminato.

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