Modern Synthetic Methods in Carbohydrate Chemistry

From Monosaccharides to Complex Glycoconjugates

Daniel B. Werz, Sebastien Vidal

• Publisher: Wiley-VCH
• Year: 2013
• Print ISBN:
  9783527332847
• eBook ISBN:
  9783527658961
• Edition: 1
• Topic: Physical Sciences
• Subtopic: Industrial & Technical Chemistry

The fields of glycochemistry and glycoscience are rich and varied and where much can be learned from Nature. As Nature is not always able to produce carbohydrates in quantities useful for not only in research but also as therapeutic agents, new ways need to be found to optimize the yield. This book presents an overview of the latest developments in the field of carbohydrates, ranging from de-novo approaches via cyclodextrin chemistry to the synthesis of such highly complex glycoconjugates as glycosphingolipids and GPI anchors.

The main emphasis remains on the synthetic aspects making the book an excellent source of information for those already involved in carbohydrate chemistry, as well as for those organic chemists who are beginners in this field. Equally of interest to synthetic chemists, as well as medicinal chemists and biochemists.

Table of contents

• Cover
• Related Titles
• Title Page
• Copyright
• Foreword
• Preface
• List of Contributors
• Chapter 1: De Novo Approaches to Monosaccharides and Complex Glycans
• Chapter 2: Synthetic Methodologies toward Aldoheptoses and Their Applications to the Synthesis of Biochemical Probes and LPS Fragments
• Chapter 3: Protecting-Group-Free Glycoconjugate Synthesis: Hydrazide and Oxyamine Derivatives in N-Glycoside Formation
• Chapter 4: Recent Developments in the Construction of cis-Glycosidic Linkages
• Chapter 5: Stereocontrol of 1,2-cis-Glycosylation by Remote O-Acyl Protecting Groups
• Chapter 6: Synthesis of Aminoglycosides
• Chapter 7: Synthesis of Natural and Nonnatural Heparin Fragments: Optimizations and Applications toward Modulation of FGF2-Mediated FGFR Signaling
• Chapter 8: Light Fluorous-Tag-Assisted Synthesis of Oligosaccharides
• Chapter 9: Advances in Cyclodextrin Chemistry
• Chapter 10: Design and Synthesis of GM1 Glycomimetics as Cholera Toxin Ligands
• Chapter 11: Novel Approaches to Complex Glycosphingolipids
• Chapter 12: Chemical Synthesis of GPI Anchors and GPI-Anchored Molecules
• Index