
Methods and Applications of Statistics in Clinical Trials, Volume 2
Planning, Analysis, and Inferential Methods
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Methods and Applications of Statistics in Clinical Trials, Volume 2
Planning, Analysis, and Inferential Methods
About this book
Methods and Applications of Statistics in Clinical Trials, Volume 2: Planning, Analysis, and Inferential Methods includes updates of established literature from the Wiley Encyclopedia of Clinical Trials as well as original material based on the latest developments in clinical trials. Prepared by a leading expert, the second volume includes numerous contributions from current prominent experts in the field of medical research. In addition, the volume features:
• Multiple new articles exploring emerging topics, such as evaluation methods with threshold, empirical likelihood methods, nonparametric ROC analysis, over- and under-dispersed models, and multi-armed bandit problems
• Up-to-date research on the Cox proportional hazard model, frailty models, trial reports, intrarater reliability, conditional power, and the kappa index
• Key qualitative issues including cost-effectiveness analysis, publication bias, and regulatory issues, which are crucial to the planning and data management of clinical trials
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Information
Table of contents
- Cover
- Half Title page
- Title page
- Copyright page
- Contributors
- Preface
- Chapter 1: Analysis of Over- and Underdispersed Data
- Chapter 2: Analysis of Variance (ANOVA)
- Chapter 3: Assessment of Health-Related Quality of Life
- Chapter 4: Bandit Processes and Response-Adaptive Clinical Trials: The Art of Exploration Versus Exploitation
- Chapter 5: Bayesian Dose-Finding Designs in Healthy Volunteers
- Chapter 6: Bootstrap
- Chapter 7: Conditional Power in Clinical Trial Monitoring
- Chapter 8: Cost-Effectiveness Analysis
- Chapter 9: Cox-Type Proportional Hazards Models
- Chapter 10: Empirical Likelihood Methods in Clinical Experiments
- Chapter 11: Frailty Models
- Chapter 12: Futility Analysis
- Chapter 13: Imaging Science in Medicine I: Overview
- Chapter 14: Imaging Science in Medicine, II: Basics of X-Ray Imaging
- Chapter 15: Imaging Science in Medicine, III: Digital (21st Century) X-Ray Imaging
- Chapter 16: Intention-to-Treat Analysis
- Chapter 17: Interim Analyses
- Chapter 18: Interrater Reliability
- Chapter 19: Intrarater Reliability
- Chapter 20: Kaplan—Meier Plot
- Chapter 21: Logistic Regression
- Chapter 22: Metadata
- Chapter 23: Microarray
- Chapter 24: Multi-Armed Bandits, Gittins Index, and Its Calculation
- Chapter 25: Multiple Comparisons
- Chapter 26: Multiple Evaluators
- Chapter 27: Noncompartmental Analysis
- Chapter 28: Nonparametric ROC Analysis for Diagnostic Trials
- Chapter 29: Optimal Biological Dose for Molecularly Targeted Therapies
- Chapter 30: Over- and Underdispersion Models
- Chapter 31: Permutation Tests in Clinical Trials
- Chapter 32: Pharmacoepidemiology, Overview
- Chapter 33: Population Pharmacokinetic and Pharmacodynamic Methods
- Chapter 34: Proportions: Inferences and Comparisons
- Chapter 35: Publication Bias
- Chapter 36: Quality of Life
- Chapter 37: Relative Risk Modeling
- Chapter 38: Sample Size Considerations for Morbidity/Mortality Trials
- Chapter 39: Sample Size for Comparing Means
- Chapter 40: Sample Size for Comparing Proportions
- Chapter 41: Sample Size for Comparing Time-to-Event Data
- Chapter 42: Sample Size for Comparing Variabilities
- Chapter 43: Screening, Models of
- Chapter 44: Screening Trials
- Chapter 45: Secondary Efficacy End Points
- Chapter 46: Sensitivity, Specificity, and Receiver Operator Characteristic (ROC) Methods
- Chapter 47: Software for Genetics/Genomics
- Chapter 48: Stability Study Designs
- Chapter 49: Subgroup Analysis
- Chapter 50: Survival Analysis, Overview
- Chapter 51: The FDA and Regulatory Issues
- Chapter 52: The Kappa Index
- Chapter 53: Treatment Interruption
- Chapter 54: Trial Reports: Improving Reporting, Minimizing Bias, and Producing Better Evidence-Based Practice
- Chapter 55: U.S. Department of Veterans Affairs Cooperative Studies Program
- Chapter 56: Women’s Health Initiative: Statistical Aspects and Selected Early Results
- Chapter 57: World Health Organization (WHO): Global Health Situation
- Index