Targeting Protein Kinases for Cancer Therapy

David J. Matthews, Mary E. Gerritsen, Mary E. Gerritsen

• Publisher: Wiley
• Year: 2011
• Print ISBN:
  9780470229651
• eBook ISBN:
  9781118210772
• Edition: 1
• Topic: Medicine
• Subtopic: Pharmacology

An expert guide to targeting protein kinases in cancer therapy

Research has shown that protein kinases can instigate the formation and spread of cancer when they transmit faulty signals inside cells. Because of this fact, pharmaceutical scientists have targeted kinases for intensive study, and have been working to develop medicinal roadblocks to sever their malignant means of communication.

Complete with full-color presentations, Targeting Protein Kinases for Cancer Therapy defines the structural features of protein kinases and examines their cellular functions. Combining kinase biology with chemistry and pharmacology applications, this book enlists emerging data to drive the discovery of new cancer-fighting drugs. Valuable information includes:

• Comprehensive overviews of the major kinase families involved in oncology, integrating protein structure and function, and providing important tools to assist pharmaceutical researchers to understand and work in this dynamic area of cancer drug research

• Focus on small molecule inhibitors as well as other therapeutic modalities

• Discussion of kinase inhibitors that have entered clinical trials for the treatment of cancer, with an emphasis on molecules that have progressed to late stage clinical trials and, in a few cases, to market

Providing a platform for further study, this important work reviews both the successes and challenges of kinase inhibitor therapy, and provides insight into future directions in the war against cancer.

Table of contents

• COVER
• TITLE
• COPYRIGHT
• PREFACE
• ACKNOWLEDGMENTS
• CHAPTER 1: KINASES AND CANCER
• CHAPTER 2: PROTEIN KINASE STRUCTURE, FUNCTION, AND REGULATION
• CHAPTER 3: RECEPTOR TYROSINE KINASES
• CHAPTER 4: NONRECEPTOR TYROSINE KINASES
• CHAPTER 5: INTRACELLULAR SIGNAL TRANSDUCTION CASCADES
• CHAPTER 6: CELL CYCLE CONTROL
• CHAPTER 7: STRUCTURAL BIOCHEMISTRY OF KINASE INHIBITORS
• CHAPTER 8: TYROSINE KINASE INHIBITORS
• CHAPTER 9: ANGIOKINASE INHIBITORS
• CHAPTER 10: INTRACELLULAR SIGNALING KINASE INHIBITORS
• CHAPTER 11: CURRENT CHALLENGES AND FUTURE DIRECTIONS
• LIST OF ABBREVIATIONS
• APPENDIX I: TUMOR ASSOCIATED MUTATIONS IN EGFR
• APPENDIX II: TUMOR ASSOCIATED MUTATIONS IN ERBB2
• APPENDIX III: TUMOR ASSOCIATED MUTATIONS IN ALK
• APPENDIX IV: TUMOR ASSOCIATED MUTATIONS IN PDGFRα
• APPENDIX V: TUMOR ASSOCIATED MUTATIONS IN FGFR1
• APPENDIX VI: TUMOR ASSOCIATED MUTATIONS IN FGFR2
• APPENDIX VII: TUMOR ASSOCIATED MUTATIONS IN FGFR3
• APPENDIX VIII: TUMOR ASSOCIATED MUTATIONS IN FGFR4
• APPENDIX IX: TUMOR ASSOCIATED MUTATIONS IN KIT
• APPENDIX X: TUMOR ASSOCIATED MUTATIONS IN FLT3
• APPENDIX XI: TUMOR ASSOCIATED MUTATIONS IN RET
• APPENDIX XII: TUMOR ASSOCIATED MUTATIONS IN MET
• APPENDIX XIII: TUMOR ASSOCIATED MUTATIONS IN JAK2
• APPENDIX XIV: TUMOR ASSOCIATED MUTATIONS IN PIK3CA
• APPENDIX XV: TUMOR ASSOCIATED MUTATIONS IN BRAF
• APPENDIX XVI: TUMOR ASSOCIATED KINASE DOMAIN MUTATIONS IN ABL
• INDEX