Medicinal Chemistry of Nucleic Acids

Lihe Zhang, Zhen Xi, Jyoti Chattopadhyaya, Li-He Zhang, Zhen Xi, Jyoti Chattopadhyaya, Li-He Zhang, Zhen Xi, Jyoti Chattopadhyaya

• Publisher: Wiley
• Year: 2011
• Print ISBN: 9780470596685
• eBook ISBN: 9781118092811
• Edition: 1
• Topic: Medicine
• Subtopic: Pharmacology

Complete, up-to-date coverage of the broad area of nucleic acid chemistry and biology

Assembling contributions from a collection of authors with expertise in all areas of nucleic acids, medicinal chemistry, and therapeutic applications, Medicinal Chemistry of Nucleic Acids presents a thorough overview of nucleic acid chemistry—a rapidly evolving and highly challenging discipline directly responsible for the development of antiviral and antitumor drugs. This reliable resource delves into a multitude of subject areas involving the study of nucleic acids—such as the new advances in genome sequencing, and the processes for creating RNA interference (RNAi) based drugs—to assist pharmaceutical researchers in removing roadblocks that hinder their ability to predict drug efficacy. Offering the latest cutting-edge science in this growing field, Medicinal Chemistry of Nucleic Acids includes:

• In-depth coverage of the development and application of modified nucleosides and nucleotides in medicinal chemistry
  
  

• A close look at a large range of current topics on nucleic acid chemistry and biology
  
  

• Essential information on the use of nucleic acid drugs to treat diseases like cancer
  
  

• A thorough exploration of siRNA for RNAi and the regulation of microRNA, non-coding RNA (ncRNA), a newly developing and exciting research area
  
  

Thorough in its approach and promising in its message, Medicinal Chemistry of Nucleic Acids probes the new domains of pharmaceutical research—and exposes readers to a wealth of new drug discovery opportunities emerging in the dynamic field of nucleic acid chemistry.

Table of contents

• Cover
• Series Page
• Title Page
• Copyright
• Foreword
• Contributors
• Introduction
• Chapter 1: Recent Advances in Carbocyclic Nucleosides: Synthesis and Biological Activity
• Chapter 2: Structures and Functions of Nucleic Acids Modified with S, Se, and Te and Complexed with Small Molecules
• Chapter 3: Unraveling the NAD Cyclizing and Calcium Signaling Functions of Human CD38
• Chapter 4: DNA and RNA binding small molecules
• Chapter 5: G-Quadruplex DNA and Its Ligands in Anticancer Therapy
• Chapter 6: Molecular Modeling in Nucleic Acid-Targeted Drug Design
• Chapter 7: Structure of 10–23 DNAzyme in Complex with the Target RNA in silico—A Progress Report on the Mechanism of RNA Cleavage by DNA enzyme
• Chapter 8: Labeling Oligonucleotides toward the Biomedical Probe
• Chapter 9: Locked Nucleic Acid Oligonucleotides Toward Clinical Applications
• Chapter 10: The Pharmacokinetics Research of Nucleic Acid Drugs
• Chapter 11: Inducible RNA and Drug Target Validation
• Chapter 12: siRNA: The Specificity and Off-Target Effects
• Color Plates
• Wiley Series
• Index