Clinical Significance
State of consciousness is the most basic quality of mind. The term āstate of consciousnessā is both hard to define and also intuitively understood. The term refers to an individualās degree of awareness or alertness. Descriptively, disturbances in consciousness lie on a continuum from clouding of consciousness or dulled awareness, to lethargy, somnolence, obtundation, stupor, and coma.
Loss of consciousness for any period of time will be associated with a gap in memory, a lapse in the individualās sense of time. Milder disturbances in consciousness may or may not be associated with memory loss.
Any loss of consciousness or disturbance in consciousness, however brief, is highly significant and always associated with underlying physical factors or medical disease. In patients who present with psychological symptoms, brief alterations in consciousness, periods of mental āabsence,ā or clouding of consciousness may be the only clue to the presence of a medical disease.
In a normal individual, alertness varies over the course of a day from the fully awake and alert state, to drowsiness and then sleep. A healthy person always can be aroused by environmental stimulation to full wakefulness, a state in which the individual is aware of self and surroundings and able to shift attention smoothly. The individual is also able to carry on some meaningful interpersonal interaction with others, although physical or psychological difficulties may limit the nature of the interaction.
In contrast, patients who are experiencing pathological states of consciousness may exhibit degrees of underresponsiveness to environmental stimulation and/or generalized overresponsiveness. The seemingly contradictory nature of this state might be best grasped by thinking of alcohol intoxication; on one hand, individuals who have had too much to drink might become somnolent and unaware of activities in the environment; on the other hand, they might become globally agitated when friends try to rouse and engage them.
Unusual states of consciousness related to sleep are covered in the section called āVegetative Symptoms.ā
Altered sense of reality or time is discussed in the section called āThought Content and Experience of Reality.ā
Altered states of consciousness with automatic behavior or with catatonia are discussed in the section called āMotor Behavior.ā
Clinical Observations
State of consciousness is assessed by observation of the patient over time and in response to different environmental situations. The reports of other clinicians and/or family members may be helpful.
Subtle or brief alterations in consciousness may be missed or misinterpreted. Clinicians might mistake very brief episodes of loss of consciousness for dissociative episodes, lapses of attention, or thought blocking. Clouding of consciousness may be mistaken for depression, lack of motivation, or normal sleepiness. Mild clouding of consciousness and subtle pathological hyperarousal or hypo-arousal may be difficult to distinguish from a mood disorder with irritability or an anxiety disorder with agitation.
Fluctuating levels of consciousness are a key feature of the most common form of presentation for medical diseaseāa delirium. Clinically, individuals with delirium may be near normal at one point in time and just hours later exhibit impairment in consciousness (see the section called āDeliriumā).
When patients have a mild clouding of consciousness along with other, more prominent features of a delirium such as agitation and hallucinations, they may be misdiagnosed with a psychotic disorder.
Any impairment in consciousness will affect an individualās other cognitive abilities, most notably attention and memory. This fact needs to be taken into account when conducting an interview, performing a mental status examination, and formulating clinical information.
Episode(s) with Loss of Consciousness
Any episode involving loss of consciousness should be investigated medically. Most often these incidents are reported to the clinician rather than observed by him/her. Patients may refer to these episodes as āfainting,ā āblacking out,ā or āhaving a fit.ā
Learning what the patient recalls about the incident, distinguishing a loss of consciousness from a loss of muscle strength or coordination, and determining whether the patient was injured can be useful information. Obtaining the report of any witnesses to the event also may be extremely helpful.
Brief Lapses in Consciousness
Brief lapses in consciousness, especially those that last only seconds, may be readily missed or misinterpreted. During these episodes, a patient will be unaware and unresponsive to the environment. Other behaviors (such as chewing or eye movements) may or may not accompany these absence episodes. It is important to investigate the possibility that these may represent seizures or episodes of microsleep.
Mild Disturbances in Consciousness
Patients with mild disturbances in consciousness may present in a variety of ways. They may display fluctuations in their state of alertness. Although seeming to be alert, their comments may reveal that they have not fully followed the conversation. Patients may also have a distorted sense of the passage of time, may lack clarity and coherence in their thinking, or they may be difficult to engage.
Patients with mild disturbances in consciousness may exhibit a decline in their day-to-day level of functioning; they may be unkempt or have episodes of incontinence. These individuals also may present with disruptions of their sleep/wake cycle; they may be drowsy during the day and restless at night.
Moderate Disturbances in Consciousness
Patients with moderate disturbances in consciousness have lethargy or somnolence. They display an abnormal degree of drowsiness, tending to fall asleep when not stimulated by activity in the environment. When not asleep, they are not fully alert. This pathological state is different from fatigue, which is a subjective feeling of tiredness that can be relieved by sleep.
Profound Disturbances in Consciousness
The most profound disturbances in consciousness and arousal are obvious and rarely missed. Obtunded patients are difficult to arouse; when aroused, they are generally in a confused state and able to be only minimally cooperative. A stupor is an unresponsive state from which the patient can be briefly aroused, but only with vigorous stimulation. A coma is a state from which a patient cannot be aroused, even with vigorous stimulation. Some of the behaviors of patients who are in a persistent vegetative state may resemble consciously motivated actions although they are not (for example, the patientās eyes may track someone around the room); these behaviors may lead to misinterpretation by family members and by clinicians.
Confusion
The term āconfusionā is imprecise; however, it is often used to describe patients in clinical situations. In common usage, āconfusionā may refer to patients who are disoriented, behaving irrationally, or not making sense in their verbal communications. The term is included in this section because patients who give the clinical impression of being confused often have a clouding of consciousness.
Some Diseases that May Present with Clouding of Consciousness
- #2 Acute Intermittent Porphyria, #6 Brain Tumors, #7 Carbon Monoxide Poisoning (high dose or chronic, low-dose exposure), #9 Chronic Subdural Hematoma, #17 Hashimotoās Encephalopathy, #18 Hepatic Encephalopathy, #28 Hypothyroidism (with myxedema coma), #29 Hypoxia, #30 Lead Poisoning, #34 Merc...