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eBook - ePub
Antiviral Drug Strategies
About this book
By focusing on general molecular mechanisms of antiviral drugs rather than therapies for individual viruses, this ready reference provides the critical knowledge needed to develop entirely novel therapeutics and to target new viruses.
It begins with a general discussion of antiviral strategies, followed by a broad survey of known viral targets, such as reverse transcriptases, proteases, neuraminidases, RNA polymerases, helicases and primases, as well as their known inhibitors. The final section contains several cases studies of recent successful antiviral drug development.
Edited by Erik de Clercq, the world authority on small molecule antiviral drugs, who has developed more new antivirals than anyone else.
It begins with a general discussion of antiviral strategies, followed by a broad survey of known viral targets, such as reverse transcriptases, proteases, neuraminidases, RNA polymerases, helicases and primases, as well as their known inhibitors. The final section contains several cases studies of recent successful antiviral drug development.
Edited by Erik de Clercq, the world authority on small molecule antiviral drugs, who has developed more new antivirals than anyone else.
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Please note we cannot support devices running on iOS 13 and Android 7 or earlier. Learn more about using the app.
Yes, you can access Antiviral Drug Strategies by Erik De Clercq, Raimund Mannhold,Hugo Kubinyi,Gerd Folkers in PDF and/or ePUB format, as well as other popular books in Medicine & Pharmacology. We have over one million books available in our catalogue for you to explore.
Information
Table of contents
- Cover
- Methods and Principles in Medicinal Chemistry
- Title Page
- Copyright
- List of Contributors
- Preface
- A Personal Foreword
- Chapter 1: Outlook of the Antiviral Drug Era, Now More Than 50 Years After Description of the First Antiviral Drug
- Chapter 2: Inhibition of HIV Entry
- Chapter 3: Targeting Integration Beyond Strand Transfer: Development of Second-Generation HIV Integrase Inhibitors
- Chapter 4: From Saquinavir to Darunavir: The Impact of 10 Years of Medicinal Chemistry on a Lethal Disease
- Chapter 5: Acyclic and Cyclic Nucleoside Phosphonates
- Chapter 6: HelicaseāPrimase Inhibitors: A New Approach to Combat Herpes Simplex Virus and Varicella Zoster Virus
- Chapter 7: Cyclophilin Inhibitors
- Chapter 8: Alkoxyalkyl Ester Prodrugs of Antiviral Nucleoside Phosphates and Phosphonates
- Chapter 9: Maribavir: A Novel Benzimidazole Ribonucleoside for the Prevention and Treatment of Cytomegalovirus Diseases
- Chapter 10: Anti-HCMV Compounds
- Chapter 11: Lethal Mutagenesis as an Unconventional Approach to Combat HIV
- Chapter 12: Recent Progress in the Development of HCV Protease Inhibitors
- Chapter 13: Antiviral RNAi: How to Silence Viruses
- Chapter 14: Neuraminidase Inhibitors as Anti-Influenza Agents
- Chapter 15: From TIBO to Rilpivirine: The Chronicle of the Discovery of the Ideal Nonnucleoside Reverse Transcriptase Inhibitor
- Index