Antiviral Drug Strategies
eBook - ePub

Antiviral Drug Strategies

  1. English
  2. ePUB (mobile friendly)
  3. Available on iOS & Android
eBook - ePub

Antiviral Drug Strategies

About this book

By focusing on general molecular mechanisms of antiviral drugs rather than therapies for individual viruses, this ready reference provides the critical knowledge needed to develop entirely novel therapeutics and to target new viruses.
It begins with a general discussion of antiviral strategies, followed by a broad survey of known viral targets, such as reverse transcriptases, proteases, neuraminidases, RNA polymerases, helicases and primases, as well as their known inhibitors. The final section contains several cases studies of recent successful antiviral drug development.
Edited by Erik de Clercq, the world authority on small molecule antiviral drugs, who has developed more new antivirals than anyone else.

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Information

Publisher
Wiley-VCH
Year
2011
Print ISBN
9783527326969
eBook ISBN
9783527635962
Edition
1
Topic
Medicine
Subtopic
Pharmacology

Table of contents

  1. Cover
  2. Methods and Principles in Medicinal Chemistry
  3. Title Page
  4. Copyright
  5. List of Contributors
  6. Preface
  7. A Personal Foreword
  8. Chapter 1: Outlook of the Antiviral Drug Era, Now More Than 50 Years After Description of the First Antiviral Drug
  9. Chapter 2: Inhibition of HIV Entry
  10. Chapter 3: Targeting Integration Beyond Strand Transfer: Development of Second-Generation HIV Integrase Inhibitors
  11. Chapter 4: From Saquinavir to Darunavir: The Impact of 10 Years of Medicinal Chemistry on a Lethal Disease
  12. Chapter 5: Acyclic and Cyclic Nucleoside Phosphonates
  13. Chapter 6: Helicase–Primase Inhibitors: A New Approach to Combat Herpes Simplex Virus and Varicella Zoster Virus
  14. Chapter 7: Cyclophilin Inhibitors
  15. Chapter 8: Alkoxyalkyl Ester Prodrugs of Antiviral Nucleoside Phosphates and Phosphonates
  16. Chapter 9: Maribavir: A Novel Benzimidazole Ribonucleoside for the Prevention and Treatment of Cytomegalovirus Diseases
  17. Chapter 10: Anti-HCMV Compounds
  18. Chapter 11: Lethal Mutagenesis as an Unconventional Approach to Combat HIV
  19. Chapter 12: Recent Progress in the Development of HCV Protease Inhibitors
  20. Chapter 13: Antiviral RNAi: How to Silence Viruses
  21. Chapter 14: Neuraminidase Inhibitors as Anti-Influenza Agents
  22. Chapter 15: From TIBO to Rilpivirine: The Chronicle of the Discovery of the Ideal Nonnucleoside Reverse Transcriptase Inhibitor
  23. Index

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Yes, you can access Antiviral Drug Strategies by Erik De Clercq, Raimund Mannhold,Hugo Kubinyi,Gerd Folkers in PDF and/or ePUB format, as well as other popular books in Medicine & Pharmacology. We have over 1.5 million books available in our catalogue for you to explore.