Solid State Characterization of Pharmaceuticals

Richard A. Storey, Ingvar Ymén, Richard A. Storey, Ingvar Ymén

• Publisher: Wiley-Blackwell
• Year: 2011
• Print ISBN:
  9781405134941
• eBook ISBN:
  9781119970170
• Edition: 1
• Topic: Physical Sciences
• Subtopic: Analytic Chemistry

The field of solid state characterization is central to the pharmaceutical industry, as drug products are, in an overwhelming number of cases, produced as solid materials. Selection of the optimum solid form is a critical aspect of the development of pharmaceutical compounds, due to their ability to exist in more than one form or crystal structure (polymorphism). These polymorphs exhibit different physical properties which can affect their biopharmaceutical properties.

This book provides an up-to-date review of the current techniques used to characterize pharmaceutical solids. Ensuring balanced, practical coverage with industrial relevance, it covers a range of key applications in the field. 

The following topics are included:    

• Physical properties and processes
• Thermodynamics
• Intellectual  guidance
• X-ray diffraction
• Spectroscopy Microscopy
• Particle sizing
• Mechanical properties
• Vapour sorption
• Thermal analysis & Calorimetry
• Polymorph prediction
• Form selection

Table of contents

• Cover
• Title Page
• Copyright
• List of Contributors
• About the Editors
• Preface
• Chapter 1: Introduction to the Solid State – Physical Properties and Processes
• Chapter 2: X-Ray Diffraction
• Chapter 3: Spectroscopic Characterization
• Chapter 4: Thermal Analysis – Conventional Techniques
• Chapter 5: Thermal Analysis—Dielectric Techniques
• Chapter 6: Isothermal Calorimetric Analysis
• Chapter 7: Calorimetric Methods—Solution Calorimetry
• Chapter 8: Vapour Sorption and Surface Analysis
• Chapter 9: Microscopy
• Chapter 10: Particulate Analysis – Mechanical Properties
• Chapter 11: Particulate Analysis – Particle Size
• Chapter 12: Computational Polymorph Prediction
• Chapter 13: Patenting of Inventions Relating to Polymorphs
• Chapter 14: A ‘Roadmap’ to Solid Form Selection
• Index