Polyketides and Steroids
eBook - ePub

Polyketides and Steroids

  1. 566 pages
  2. English
  3. ePUB (mobile friendly)
  4. Available on iOS & Android
eBook - ePub

Polyketides and Steroids

About this book

This 8-volume set provides a systematic description on 8, 350 active marine natural products from 3, 025 various kinds of marine organisms. The diversity of structures, biological resources and pharmacological activities are discussed in detail. Molecular structural classification system with 264 structural types are developed as well. The 5th volume mainly illustrates the molecular formula and structures of polyketides and steroids.

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Yes, you can access Polyketides and Steroids by Jiaju Zhou in PDF and/or ePUB format, as well as other popular books in Physical Sciences & Biochemistry. We have over one million books available in our catalogue for you to explore.

Information

Publisher
De Gruyter
Year
2019
Print ISBN
9783110653632
eBook ISBN
9783110653717
Edition
1
Topic
Physical Sciences
Subtopic
Biochemistry

1 Polyketides

1.1 Linear Polyketides

1 Balticolid

Type: Linear polyketides nobranched. C12H16O4 Colorless oil, [α]D22 = +135.2° (c = 0.35, MeOH). Source: An unidentified ascomycetous fungus (drift-wood, Greifswalder Bodden, Baltic Sea, Germany). Pharm: Anti-HSV-1 (IC50 = 0.45 μmol/L). Ref: M. A. M. Shushni, et al, Mar. Drugs, 2011, 9, 844│S. Z. Moghadamtousi, et al, Mar. Drugs, 2015, 13, 4520 (rev)

2 Aureoverticillactam

Type: Linear polyketides monobranched. C28H39NO4 Amorph. solid. Source: Marine-derived streptomycete Streptomyces aureoverticillatus NPS001583. Pharm: Cytotoxic (HT29, EC50 = (3.6 ± 2.6)μmol/L; B16-F-10, EC50 = (2.2 ± 0.9)μmol/L; JurKat, EC50 = (2.3 ± 1.1)μmol/L). Ref: S. S. Mitchell, et al, JNP, 2004, 67, 1400

3 Cyanolide A

Type: Linear polyketides dibranched. C42H72O16 Oil, [α]D23 = −59° (c = 0.6, CHCl3). Source: Cyanobacterium Lyngbya bouillonii (Pigeon I., Papua New Guinea). Pharm: Molluscacidal (snail vector Biomphalaria glabrata, LC50 = 1.2 μmol/L, very potent; molluscacides play a critical role in control of schistosomiasis transmission); toxic (brine shrimp, LC50 = 10.8 μmol/L). Ref: H. Kim, et al, Org. Lett., 2010, 12, 2880│A. R. Pereira, et al, JNP, 2010, 73, 217

4 Formosalide A

Type: Linear polyketides dibranched. C32H50O9 Amorph. solid, [α]D25 = +17.3° (c = 0.01, MeOH). Source: Dinoflagellate Prorocentrum sp. (seaweed washings, South Bay, Taiwan). Pharm: Cytotoxic (CCRF-CEM, LD50 = 0.54 μg/mL, DLD-1, LD50 > 40 μg/mL). Ref: C. -K. Lu, et al, Tet. Lett., 2009, 50, 1825

5 Formosalide B

Type: Linear polyketides dibranched. C33H52O9 Amorph. solid, [α]D24 = +18.8° (c = 0.04, MeOH). Source: Dinoflagellate Prorocentrum sp. (seaweed washings, South Bay, Taiwan). Pharm: Cytotoxic (CCRF-CEM, LD50 = 0.43 μg/mL, DLD-1, LD50 = 2.73 μg/mL). Ref: C. -K. Lu, et al, Tet. Lett., 2009, 50, 1825

6 Koshikalide

Type: Linear polyketides dibranched. C17H26O4 Oil, [α]D22 = +156° (c = 0.03, MeOH). Source: Cyanobacterium Lyngbya sp. Pharm: Cytotoxic (HeLa-S3 cells, IC50 = 42 μg/mL, weak). Ref: A. Iwasaki, et al, Tet. Lett., 2010, 51, 959

7 Colopsinol A

Type: Linear polyketides tribranched. C72H120O25S [α]D20 = −11° (c = 0.35, MeOH). Source: Dinoflagellate Amphidinium sp. Y-5. Pharm: DNA polymerase α inhibitor (IC50 = 13 μmol/L). DNA polymerase β inhibitor (IC50 = 7 μmol/L). Ref: J. Kobayashi, et al, JOC, 1999, 64, 1478│T. Kubota, et al, JCS Perkin I, 1999, 3483│J. Kobayashi, et al, Pure Appl Chem, 2003, 75:337

8 Colopsinol C

Type: Linear polyketides tribranched. C62H104O20S ...

Table of contents

  1. Title Page
  2. Copyright
  3. Contents
  4. Preface
  5. About the Author
  6. Introduction
  7. How to Use the HAMNP Books
  8. List of Abbreviations and Acronyms
  9. List of Cancer Cell Codes
  10. 1 Polyketides
  11. 2 Steroids
  12. Index 1 Compound Name and Synonym Index
  13. Index 2 Compound Molecular Formula Index
  14. Index 3 Compound Organism Source Index
  15. Index 4 Compound Sampling Geographic Locality Index
  16. Index 5 Compound Pharmacological Activity Index