Blood Results in Clinical Practice
- 92 pages
- English
- ePUB (mobile friendly)
- Available on iOS & Android
Blood Results in Clinical Practice
About This Book
This book was written after feedback suggested that stories and analogies were very helpful to students wanting to remember blood tests and their implications. For this reason each section, where appropriate, contains an analogy, in addition to an overview of the relevant anatomy, physiology and biochemistry. The book links tests and conditions, and gives strategies for clinical practice using simple language.It will be useful as a supplementary text for those studying nursing, healthcare and medicine. It will also provide a quick-reference handbook for working healthcare professionals. Finally, it will provide a resource for patients and their relatives who may be keen to know more about the meaning and function of a particular blood test.
Frequently asked questions
Information
1
Understanding blood tests
Quick reference glossary
Full blood count (FBC) | |
Platelet | ā¢ Cell that causes the blood to clot ā¢ Also a marker of bone marrow function ā¢ Decreased in some leukaemia and myelomas ā¢ Additional test is mean platelet volume (MPV) |
White blood cell count (WBC) | ā¢ The total number of white cells in the blood |
Neutrophil | ā¢ A type of white blood cell ā¢ Responds to tissue damage via C-reactive protein (or CRP) ā¢ Raised in bacterial infections, autoimmune conditions ā¢ āThe fire engineā |
Lymphocyte | ā¢ A type of white blood cell ā¢ Makes antibodies ā¢ Raised in viral infections and some myelomas ā¢ āThe policeā |
Monocyte | ā¢ A type of white blood cell ā¢ Infiltrates the tissue in systemic bacterial infections ā¢ Linked to cardiovascular disease and high low-density lipoprotein (LDL) cholesterol ā¢ āThe minerā |
Basophil | ā¢ A type of white blood cell ā¢ Important in allergic responses and hypersensitivity |
Eosinophil | ā¢ A type of white blood cell ā¢ Important in allergic responses and hypersensitivity |
Blast/Atypical | ā¢ A type of dysfunctional white cell ā¢ Raised in leukaemia and myelomas |
Haematocrit (Hct) | ā¢ Percentage of red blood cells in the whole blood ā¢ Decreased in anaemia ā¢ Elevated in polycythaemia |
Haemoglobin (Hb) | ā¢ The oxygen-carrying protein in the red blood cell ā¢ Decreased in anaemia ā¢ Elevated in polycythaemia |
Red blood cell count (RBC) | ā¢ The total number of red blood cells in the blood as a count ā¢ Decreased in anaemia ā¢ Elevated in polycythaemia |
Mean cell volume (MCV) | ā¢ The average size of the red blood cells ā¢ Low in iron deficient anaemia ā¢ Normal in blood loss anaemia ā¢ High in folate and B12 deficient anaemia |
Inflammatory markers | |
Plasma viscosity (PV) | ā¢ A measure of more āstuffā in the blood ā¢ Thus, a surrogate, non-specific marker of ā¢ inflammation ā¢ Increased in autoimmune conditions, infection, cell damage, cancer, myelomas ā¢ āThe traffic jam due to fire engines and police (white cells)ā ā¢ Could remain raised for two weeks post-injury, as increased white cells have around two-week lifespan |
Erythrocyte sedimentation rate (ESR) | ā¢ How quickly red blood cells fall in a tube, in a lab ā¢ A surrogate, non-specific, marker of inflammation that has elicited a fibrinogen response ā¢ Fibrinogen āsticksā red blood cells together so they become heavier and fall more quickly ā¢ Could be normal in low damage inflammation as seen in some autoimmune conditions ā¢ āThe scaffolding and building-supporting structure following a large fireā ā¢ If raised, could remain raised for a significant time post-event |
C-reactive protein (CRP) | ā¢ A chemo-attractant protein released in response to tissue damage ā¢ āThe fire alarmā ā¢ Possible to miss the CRP response post-injury whilst still having raised PV and ESR ā¢ Increasingly being used as a sensitive marker for atherosclerotic vascular damage to indicate cardiovascular risk |
Urea and electrolytes (U&Es), Kidney function | |
Sodium (Na) | ā¢ Extracellular electrolyte that controls water balance and blood pressure ā¢ Raised in dehydration, |
Potassium (K) | ā¢ Intracellular electrolyte, controls cellular pumps and receptors via electric potential ā¢ Therefore a red flag if in high concentrations in the blood |
Urea | ā¢ A marker of acute renal dysfunction, such as distress, although this could be something like dehydration, so |
Creatinine | ā¢ A marker of chronic renal function, such as a renal stone |
Estimated glomerular filtration rate (eGFR) | ā¢ A general marker of kidney function ā¢ Used to diagnose chronic kidney disease staging ā¢ Used to confirm renal dysfunction as cause of other conditions such as renal anaemia |
Liver function tests (LFTs) | |
Alanine aminotransferase (ALT) | ā¢ A liver enzyme ā¢ Often raised in trauma, drug toxicity, and viral hepatitis |
Aspartate aminotransferase (AST) | ā¢ A liver enzyme ā¢ Often raised in trauma, acute alcohol hepatitis and liver failure ā¢ Also found in the heart so |
Gamma-glutamyl transferase (GGT) | ā¢ A liver enzyme ā¢ Often raised following alcohol intake ā¢ |
Alkaline phosphatase | ā¢ A liver enzyme ā¢ Often increased in biliary tree damage such as gallstones Also found in the bone (check Ca), kidney (check ā¢ U&Es) and placenta (check age and gender) |
Amylase | ā¢ A liver enzyme ā¢ Often increased in pancreatitis and pancreatic tumours |
Bilirubin | ā¢ A marker of the āplumbingā of the liver ā¢ Increased in jaundice, usually caused by pre-, actual or post-hepatic blockage |
Urobilinogen | ā¢ A bilirubin breakdown product, usually absent in post-hepa... |