Antisense Drug Technology
eBook - PDF

Antisense Drug Technology

Principles, Strategies, and Applications, Second Edition

  1. 848 pages
  2. English
  3. PDF
  4. Available on iOS & Android
eBook - PDF

Antisense Drug Technology

Principles, Strategies, and Applications, Second Edition

About this book

Extensively revised and updated, Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition reflects the logarithmic progress made in the past four years of oligonucleotide-based therapies, and, in particular, antisense therapeutics and research. Interpreting lessons learned from the clinical trials of first generati

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Yes, you can access Antisense Drug Technology by Stanley T. Crooke in PDF and/or ePUB format, as well as other popular books in Medicine & Biotechnology in Medicine. We have over one million books available in our catalogue for you to explore.

Information

Publisher
CRC Press
Year
2007
Print ISBN
9780849387968
eBook ISBN
9781439832509
Edition
2
Topic
Medicine
Subtopic
Biotechnology in Medicine

Table of contents

  1. Front cover
  2. Contents
  3. Preface
  4. Acknowledgments
  5. The Editor
  6. Contributors
  7. Part I: Introduction
  8. Chapter 1. Mechanisms of Antisense Drug Action, an Introduction
  9. Chapter 2. The RNase H Mechanism
  10. Chapter 3. Small RNA Silencing Pathways
  11. Chapter 4. Splice Switching Oligonucleotides as Potential Therapeutics
  12. Part II: The Basics of Oligonucleotide-Based Therapeutics
  13. Chapter 5. Basic Principles of Antisense Drug Discovery
  14. Chapter 6. The Medicinal Chemistry of Oligonucleotides
  15. Chapter 7. Basic Principles of the Pharmacokinetics of Antisense Oligonucleotide Drugs
  16. Chapter 8. Routes and Formulations for Delivery of Antisense Oligonucleotides
  17. Chapter 9. Liposomal Formulations for Nucleic Acid Delivery
  18. Part III A: Hybridization-Based Drugs: Basic Properties
  19. Chapter 10. Pharmacological Properties of 2'-O-Methoxyethyl-Modified Oligonucleotides
  20. Chapter 11. Pharmacokinetic/Pharmacodynamic Properties of Phosphorothioate 2'-O-(2-Methoxyethyl)-Modified Antisense Oligonucleotides in Animals and Man
  21. Chapter 12. Toxicologic Properties of 2'-O-Methoxyethyl Chimeric Antisense Inhibitors in Animals and Man
  22. Chapter 13. An Overview of the Clinical Safety Experience of First- and Second-Generation Antisense Oligonucleotides
  23. Chapter 14. Manufacturing and Analytical Processes for 2'-O-(2-Methoxyethyl)-Modified Oligonucleotides
  24. Part IIIB: Hybridization-Based Drugs: Basic Properties
  25. Chapter 15. Utilizing Chemistry to Harness RNA Interference Pathways for Therapeutics: Chemically Modified siRNAs and Antagomirs
  26. Chapter 16. Discovery and Development of RNAi Therapeutics
  27. Part IV: Other Chemical Classes of Drugs
  28. Chapter 17. Optimization of Second-Generation Antisense Drugs: Going Beyond Generation 2.0
  29. Chapter 18. Modulating Gene Function with Peptide Nucleic Acids (PNA)
  30. Chapter 19. Locked Nucleic Acid
  31. Chapter 20. Morpholinos
  32. Part V: Therapeutic Applications
  33. Chapter 21. Potential Therapeutic Applications of Antisense Oligonucleotides in Ophthalmology
  34. Chapter 22. Cardiovascular Therapeutic Applications
  35. Chapter 23. Developing Antisense Drugs for Metabolic Diseases: A Novel Therapeutic Approach
  36. Chapter 24. Inflammatory Diseases
  37. Chapter 25. Antisense Oligonucleotides for the Treatment of Cancer
  38. Chapter 26. Targeting Neurological Disorders with Antisense Oligonucleotides
  39. Chapter 27. Mechanisms and Therapeutic Applications of Immune Modulatory Oligodeoxynucleotide and Oligoribonucleotide Ligands for Toll-Like Receptors
  40. Chapter 28. Aptamer Opportunities and Challenges
  41. Index
  42. Back cover