Thiamine

Catalytic Mechanisms in Normal and Disease States

Frank Jordan, Mulchand S. Patel, Frank Jordan, Mulchand S. Patel

• Publisher: CRC Press
• Year: 2003
• Print ISBN: 9780824740627, 9780824740627
• eBook ISBN: 9781135703233
• Edition: 1
• Topic: Medicine
• Subtopic: Nutrition, Dietics & Bariatrics

Thiamine: Catalytic Mechanisms in Normal and Disease States brings together the most recent developments in thiamine diphosphate (TDP)-requiring enzyme research and details the mechanisms of catalysis and structure-function relationships, as well as pathophysiological aspects of a spectrum of diseases associated with TDP-requiring enzymes. Providin

Table of contents

• Cover
• Half Title
• Series Page
• Title Page
• Copyright Page
• Series Introduction
• Preface
• Table of Contents
• Contributors
• Thiamine
• 1Chemical Intermediates in Catalysis by Thiamine Diphosphate
• 2 Mechanistic and Structural Studies on Thiamine Biosynthetic Enzymes
• 3 Studies on the Structure and Function of Thiamine Pyrophosphokinase
• 4 New Perspectives on the Cellular Role of Thiamine Triphosphate and Thiamine Triphosphatase
• 5 How Thiamine Works in Enzymes: Time-Resolved NMR Snapshots of TDP-Dependent Enzymes in Action
• 6 Thiamine-Dependent Enzymes as Catalysts of C-C Bond-Forming Reactions: The Role of “Orphan” Enzymes
• 7Ligand-Induced Conformational Changes in Thiamine Diphosphate-Dependent Enzymes: Comparison Between Crystal and Solution Structures
• 8Enantioselective Syntheses of Hydroxy Ketones via Benzoylformate Decarboxylase-and Benzaldehyde Lyase-Catalyzed C-C Bond Formation
• 9 Benzoylformate Decarboxylase: Lessons in Enzymology
• 10New Concept on the Nature of the Induced Absorption Band of Holotransketolase
• 11Structure of the ot-Carbanion/ Enamine Reaction Intermediate in the Active Site of Transketolase, Determined by Kinetic Crystallography
• 12Yeast Pyruvate Decarboxylase: New Features of the Structure and Mechanism
• 13Solvent and Carbon Kinetic Isotope Effects on Active-Site and Regulatory-Site Variants of Yeast Pyruvate Decarboxylase
• 14Insights into the Mechanism and Regulation of Bacterial Acetohydroxyacid Synthases
• 15Structure and Properties of Acetohydroxyacid Synthase
• 16Exploring the Substrate Specificity of Benzoylformate Decarboxylase, Pyruvate Decarboxylase, and Benzaldehyde Lyase
• 17 Benzoylformate Decarboxylase: Intermediates, Transition States, and Diversions
• 18Structural and Functional Organization of Pyruvate Dehydrogenase Complexes
• 19The Pyruvate Dehydrogenase Multienzyme Complex
• 20Activation and Transfer of Lipoic Acid in Protein Lipoylation in Mammals
• 21Central Organization of Mammalian Pyruvate Dehydrogenase (PD) Complex and Lipoyl Domain-Mediated Activated Function and Control of PD Kinases and Phosphatase 1
• 22Physiological Effects of Replacing the PDH Complex of E. coli by Genetically Engineered Variants or by Pyruvate Oxidase
• 23Structure and Intersubunit Information Transfer in the E. coli Pyruvate Dehydrogenase Multienzyme Complex
• 24Structure, Function, and Regulation of Pyruvate Dehydrogenase Kinase
• 25Three-Dimensional Structures for Components and Domain of the Mammalian Branched-Chain a-Ketoacid Dehydrogenase Complex
• 26Variability of Human Pyruvate Dehydrogenase Complex Deficiency
• 27Kinetic Studies of Human Pyruvate Dehydrogenase and Its Mutants: Interactions with Thiamine Pyrophosphate
• 28The Complexity of Single-Gene Disorders: Lessons from Maple Syrup Urine Disease and Thiamine Responsiveness
• 29Thiamine Pyrophosphate: An Essential Cofactor in the Mammalian Metabolism of 3-Methyl-Branched Fatty Acids
• 30Pathogenesis of Selective Neuronal Loss in Wernicke-Korsakoff Syndrome: Role of Oxidative Stress
• 31Thiamine-Responsive Megaloblastic Anemia Syndrome: Clinical Aspects and Molecular Genetics
• 32Accomplishments and Future Directions
• Index