This unique book provides a thorough overview of developing molecular cancer diagnostic assays, which are the prerequisites for optimal solutions within personalized cancer medicine. The book takes the reader through definitions of the pharmacodiagnostic concept, historical perspectives of the early steps into molecular cancer diagnostics linked to therapy, the basis of different diagnostic molecular techniques, ongoing research, drug-diagnostic co-development, assay validation, clinical trial methodology, regulatory issues around pharmacodiagnostics and future aspects within personalized cancer medicine.

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Yes, you can access Molecular Diagnostics by Jan Trost Jorgensen, Henrik Winther, Jan Trost Jorgensen,Henrik Winther in PDF and/or ePUB format, as well as other popular books in Medicine & Oncology. We have over one million books available in our catalogue for you to explore.

Information

Publisher

Jenny Stanford Publishing

Year

2019

Print ISBN

9789814241441

eBook ISBN

9780429533693

Edition

Topic

Medicine

Subtopic

Oncology

Cover
Half Title
Title Page
Copyright Page
Table of Contents
Introduction
Developing Molecular Diagnostics in Cancer
The Estrogen and Progesterone Receptors — Setting the Scene for Pharmacodiagnostics
The Development of the HercepTest™ — From Bench to Bedside
Predictive Biomarkers and Translational Cancer Medicine
Pharmacodiagnostic Testing — Immunohistology
In Situ Hybridisation for Pharmacodiagnostic Testing
MammaPrint® Translating Research into a Diagnostic Test
DNA Biomarkers in the Diagnosis and Management of Cancer
Validating the Analytical Power and Parameters of an Immunohistochemical Test
Drug and Pharmacodiagnostic Co-Development: Statistical Considerations
Clinical Validation of Biomarkers in Cancer
Pharmacogenomic Markers for Cancer Therapy
Safety and Effective Biomakers in Oncology — A Regulatory Drug and Device Perspective
Personalizing Treatment Selection for Breast Cancer
Pharmacodiagnostics and Personalized Medicine in Cancer

About this book

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Information

Table of contents