Molecular Diagnostics

The Key in Personalized Cancer Medicine

Jan Trost Jorgensen, Henrik Winther, Jan Trost Jorgensen, Henrik Winther

• Publisher: Jenny Stanford Publishing
• Year: 2019
• Print ISBN:
  9789814241441
• eBook ISBN:
  9780429533693
• Topic: Medicine
• Subtopic: Oncology

This unique book provides a thorough overview of developing molecular cancer diagnostic assays, which are the prerequisites for optimal solutions within personalized cancer medicine. The book takes the reader through definitions of the pharmacodiagnostic concept, historical perspectives of the early steps into molecular cancer diagnostics linked to therapy, the basis of different diagnostic molecular techniques, ongoing research, drug-diagnostic co-development, assay validation, clinical trial methodology, regulatory issues around pharmacodiagnostics and future aspects within personalized cancer medicine.

Table of contents

• Cover
• Half Title
• Title Page
• Copyright Page
• Table of Contents
• Introduction
• Developing Molecular Diagnostics in Cancer
• The Estrogen and Progesterone Receptors — Setting the Scene for Pharmacodiagnostics
• The Development of the HercepTest™ — From Bench to Bedside
• Predictive Biomarkers and Translational Cancer Medicine
• Pharmacodiagnostic Testing — Immunohistology
• In Situ Hybridisation for Pharmacodiagnostic Testing
• MammaPrint® Translating Research into a Diagnostic Test
• DNA Biomarkers in the Diagnosis and Management of Cancer
• Validating the Analytical Power and Parameters of an Immunohistochemical Test
• Drug and Pharmacodiagnostic Co-Development: Statistical Considerations
• Clinical Validation of Biomarkers in Cancer
• Pharmacogenomic Markers for Cancer Therapy
• Safety and Effective Biomakers in Oncology — A Regulatory Drug and Device Perspective
• Personalizing Treatment Selection for Breast Cancer
• Pharmacodiagnostics and Personalized Medicine in Cancer