Polycystic Kidney Disease
eBook - ePub

Polycystic Kidney Disease

  1. 346 pages
  2. English
  3. ePUB (mobile friendly)
  4. Available on iOS & Android
eBook - ePub

Polycystic Kidney Disease

About this book

This volume focuses on the investigatory methods applied to autosomal dominant polycystic kidney disease (ADPKD), one of the most common human genetic diseases. ADPKD is caused by mutations in PKD1 and TRPP2, two integral membrane proteins that function as receptor/ion channels in primary cilia of tubular epithelial cells. Thus, ADPKD belongs to ciliopathies, a group of disorders caused by abnormal cilia formation or function. This proposed book will cover the state-of-the-art methods ranging from molecular biology, biochemistry, electrophysiology, to tools in model animal studies.

Key Features

  • Explores the role of cilia in polycystic kidney disease
  • Focuses on myriad state-of-the-art methods and techniques
  • Reviews specific mutations integral to this autosomal genetic disease
  • Includes discussions of model systems

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Yes, you can access Polycystic Kidney Disease by Jinghua Hu,Yong Yu in PDF and/or ePUB format, as well as other popular books in Medicine & Endocrinology & Metabolism. We have over one million books available in our catalogue for you to explore.

Information

Publisher
CRC Press
Year
2019
Print ISBN
9781032176581
eBook ISBN
9780429888946
Edition
1
Topic
Medicine
Subtopic
Endocrinology & Metabolism

Table of contents

  1. Cover
  2. Half Title
  3. Series Page
  4. Title Page
  5. Copyright Page
  6. Contents
  7. Preface
  8. Editors
  9. Contributors
  10. Chapter 1: Biochemical Analysis of the Polycystin-1 Complexity Generated by Proteolytic Cleavage at the G Protein-Coupled Receptor Proteolysis Site
  11. Chapter 2: Structural Determination of the Polycystin-2 Channel by Electron Cryo-Microscopy
  12. Chapter 3: Recording Ion Channels in Cilia Membranes
  13. Chapter 4: Electrophysiological Recording of a Gain-of-Function Polycystin-2 Channel with a Two-Electrode Voltage Clamp
  14. Chapter 5: Functional Studies of PKD2 and PKD2L1 through Opening the Hydrophobic Activation Gate
  15. Chapter 6: Analyzing the GPCR Function of Polycystin-1
  16. Chapter 7: Methods to Study the Vasculature in ADPKD
  17. Chapter 8: Energy Metabolism, Metabolic Sensors, and Nutritional Interventions in Polycystic Kidney Disease
  18. Chapter 9: “Kidney in a Dish” Organoids for PKD
  19. Chapter 10: Rodent Autosomal Dominant Polycystic Kidney Disease Models
  20. Chapter 11: Using C. elegans as a Model in PKD
  21. Chapter 12: Approaches to Studying Polycystic Kidney Disease in Zebrafish
  22. Chapter 13: Investigation of DNA Methylation in Autosomal Dominant Polycystic Kidney Disease
  23. Chapter 14: Molecular Diagnosis of Autosomal Dominant Polycystic Kidney Disease
  24. Index