BIOS Instant Notes in Medicinal Chemistry

Graham Patrick

• Publisher: Taylor & Francis
• Year: 2019
• Print ISBN:
  9781859962077
• eBook ISBN:
  9780429524318
• Edition: 1
• Topic: Physical Sciences
• Subtopic: Pharmacology

Instant Notes in Medicinal Chemistry provides concise coverage for undergraduates studying medicinal chemistry as part of a science, pharmacy or medical course. It is a truly multidisciplinary subject involving such subject specialities as organic chemistry, pharmacology, biochemistry, physiology, microbiology, toxicology, genetics and computer mod

INDEX

Acetylcholine, 10, 15–16, 71, 113–114

Acetylcholinesterase, 3, 10, 144

inhibitors, 3, 136–137

Acid anhydrides, 171

Acid chlorides, 171

Active conformation, 92, 121–122, 135, 144, 151–152

Active principles, 248–249, 268

Active sites see enzymes, active sites Acylation, 158–159, 185–187

Adalat see nifedipine Adenine, 29–30

Adenosine diphosphate, 21, 222

Adenosine triphosphate, 19–21, 222–223, 227, 234, 239–240, 242

Adenylate cyclase, 19–20

Adrenal medulla, 15

Adrenaline see epinephrine Adrenergic receptors, 16, 152, 262–263

agonists, 166

antagonists, 81 see also β-blockers

binding site, 108

Adrenoreceptors see adrenergic receptors Aerosols, 56

Affinity, 64–67, 105–106, 155

Affinity constant, 65–6

African willow tree, 79

Agonists see receptor agonists AIDS, 57, 269

AIDS drugs, clinical trials, 213–14

Alanine, 89

Albumin, 47

Alcohol, 47, 55, 212–213

Alcohols

alkylation of, 86, 118–119, 158–159

binding interactions, 111–112

bromination of, 199–200

conjugation reactions, 50

conversion to alkyl chlorides, 194

drug metabolism of, 172

esterification, 86–87, 168

hydrogen bonding, 165

isotopic labeling, 208–209

masking by prodrugs, 115, 167–168

protection of, 210

resolution of, 97–98

Aldehydes, 171

binding interactions, 113–114

isotopic labeling, 209

Aliphatic electronic substituent constants, 130

Alkaloids, 78, 248

Alkenes

asymmetric epoxidation, 95–96

asymmetric...

Table of contents

• Cover
• Half Title
• Title Page
• Copyright Page
• Table of Contents
• Abbreviations
• Preface
• About the author
• Section A – The science of medicinal chemistry
• Section B – Drug targets
• Section C – Pharmacokinetics
• Section D – Biological testing and bioassays
• Section E – Drug discovery
• Section F – Synthesis
• Section G – Structure–activity relationships
• Section H – Target orientated drug design
• Section I – Pharmacokinetic orientated drug design
• Section J – Patenting and manufacture
• Section K – Preclinical testing and clinical trials
• Section L – Case study: inhibitors of EGF-receptor kinase
• Section M – History of medicinal chemistry
• Further reading
• Index