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BIOS Instant Notes in Medicinal Chemistry
Graham Patrick
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eBook - ePub
BIOS Instant Notes in Medicinal Chemistry
Graham Patrick
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About This Book
Instant Notes in Medicinal Chemistry provides concise coverage for undergraduates studying medicinal chemistry as part of a science, pharmacy or medical course. It is a truly multidisciplinary subject involving such subject specialities as organic chemistry, pharmacology, biochemistry, physiology, microbiology, toxicology, genetics and computer mod
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INDEX
Acetylcholine, 10, 15–16, 71, 113–114
Acetylcholinesterase, 3, 10, 144
inhibitors, 3, 136–137
Acid anhydrides, 171
Acid chlorides, 171
Active conformation, 92, 121–122, 135, 144, 151–152
Active principles, 248–249, 268
Active sites see enzymes, active sites Acylation, 158–159, 185–187
Adalat see nifedipine Adenine, 29–30
Adenosine diphosphate, 21, 222
Adenosine triphosphate, 19–21, 222–223, 227, 234, 239–240, 242
Adenylate cyclase, 19–20
Adrenal medulla, 15
Adrenaline see epinephrine Adrenergic receptors, 16, 152, 262–263
agonists, 166
antagonists, 81 see also β-blockers
binding site, 108
Adrenoreceptors see adrenergic receptors Aerosols, 56
Affinity, 64–67, 105–106, 155
Affinity constant, 65–6
African willow tree, 79
Agonists see receptor agonists AIDS, 57, 269
AIDS drugs, clinical trials, 213–14
Alanine, 89
Albumin, 47
Alcohol, 47, 55, 212–213
Alcohols
alkylation of, 86, 118–119, 158–159
binding interactions, 111–112
bromination of, 199–200
conjugation reactions, 50
conversion to alkyl chlorides, 194
drug metabolism of, 172
esterification, 86–87, 168
hydrogen bonding, 165
isotopic labeling, 208–209
masking by prodrugs, 115, 167–168
protection of, 210
resolution of, 97–98
Aldehydes, 171
binding interactions, 113–114
isotopic labeling, 209
Aliphatic electronic substituent constants, 130
Alkaloids, 78, 248
Alkenes
asymmetric epoxidation, 95–96
asymmetric...