Nanotoxicology

Toxicity Evaluation, Risk Assessment and Management

Vineet Kumar, Nandita Dasgupta, Shivendu Ranjan

• Publisher: CRC Press
• Year: 2018
• Print ISBN: 9781498799416
• eBook ISBN: 9781351138185
• Topic: Medicine
• Subtopic: Toxicology

As the application of nanotechnology in the myriad disciplines of science and engineering--from agriculture, pharmaceuticals, material science, and biotechnology to sensors, electronics, and mechanical and electrical engineering--brings benefits it also can produce serious threats to human health and the environment that must be evaluated.

The unique properties of nanomaterials make them different from their bulk counterparts. In addition to such unique properties, the nanometric size of nanomaterials can invite some detrimental effects on the health and well-being of living organisms and the environment. Thus, it is important to distinguish nanomaterials with such ill effects from nanomaterials with no or minimum toxicity.

Nanotoxicology: Toxicity Evaluation, Risk Assessment and Management covers issues such as the basic principles of nanotoxicity, methods used for nanotoxicity evaluation, risk assessment and its management for nanomaterial toxicity with a focus on current trends, limitations, challenges, and future directions of nanotoxicity evaluation.

Various experts from different countries discuss these issues in detail in this book. This will be helpful to researchers, educators, and students who are interested in research opportunities for avoiding the environmental and health hazards of nanomaterials. This book will also be useful for industrial practitioners, policy makers, and other professionals in the fields of toxicology, medicine, pharmacology, food, drugs, and other regulatory sciences.

Table of contents

• Cover
• Half Title
• Title Page
• Copyright Page
• Contents
• Preface
• Editors
• Contributors
• 1. Critical Evaluation of Toxicity Tests in Context to Engineered Nanomaterials: An Introductory Overview
• 2. Ethics in Nanotechnology and Society Perception
• 3. Impact of Physicochemical Properties and Surface Chemistry of Nanomaterials on Toxicity
• 4. Application of Nanomaterials in Food, Cosmetics, and Other Related Process Industries
• 5. Effect of Route of Exposure on the Toxicity Behavior of Nanomaterials
• 6. Factors Affecting the Toxicity of Engineered Nanomaterials: Interference and Limitations of In Vitro Assays
• 7. Influence of Test Model Selection on Nanotoxicity Evaluation
• 8. Nanotoxicity In Vitro: Limitations of the Main Cytotoxicity Assays
• 9. Genotoxicity and Carcinogenicity of Daily Used Nanoparticles: In Vivo Studies
• 10. Influence of Nanomaterials on Human Health
• 11. Mechanisms of Nanotoxicity to Cells, Animals, and Humans
• 12. In Vitro Animal Nanotoxicity Evaluation: A Detailed Review
• 13. In Vivo Animal Nanotoxicity Evaluation: A Detailed Review
• 14. Nanotoxicity Evaluation Using Experimental Animals: A Detailed Review
• 15. Pharmacokinetics Approach for Nanotoxicity Evaluation
• 16. Genomic Approach of Nanotoxicity Evaluation
• 17. Nano-Genotoxicity Evaluation: A Review
• 18. Nanoinformatics: An Alternative of In Vitro and In Vivo Nanotoxicity Evaluations
• 19. In Silico Methods for Nanotoxicity Evaluation: Opportunities and Challenges
• 20. Sensors Used to Evaluate Nanotoxicity
• 21. Nanosensors: The Future of Efficient Sensing Technologies in Nanomedicine
• 22. Embryonic Stem Cell as a Cellular Model for Testing the Toxicity of Engineered Nanoparticles
• 23. Regulations for Safety Assessment of Nanomaterial
• 24. Challenges, Recommendations, and Strategies for Nanotoxicology Evaluation and Its Management
• Index