Dermatoscopy in Clinical Practice

Beyond Pigmented Lesions

Giuseppe Micali, Francesco Lacarrubba, Giuseppe Micali, Francesco Lacarrubba

• Publisher: CRC Press
• Year: 2018
• eBook ISBN: 9781315360232
• Edition: 2
• Topic: Medicine
• Subtopic: Dermatology

Dermatoscopy has been heavily promoted to dermatologists as the front line in detecting skin cancer early and easily. However, this technology also has other uses in everyday dermatologic practice.

Dermatoscopy in Clinical Practice shows those already using the equipment how they can extend its use beyond pigmented lesions and exploit its full potential. Dermatoscopy and videodermatoscopy can be used for differential diagnosis, prognostic evaluation, and monitoring response to treatment of various disorders including inflammatory diseases, parasitoses, viral and fungal infections, nonpigmented skin lesions, hair abnormalities, and a large variety of other dermatologic conditions as well as cosmetology.

The book focuses on those conditions in which the techniques are most useful, describing the clinical and histopathological correlations associated with the procedure. The book includes color clinical images throughout, making it a handy guide for the dermatologist's daily practice.

1 Equipment for dermatoscopy/videodermatoscopy

Pietro Rubegni, Niccolò Nami, Luca Feci, Marco Burroni, Linda Tognetti, and Michele Fimiani

DERMATOSCOPY

The optical dermatoscope is an instrument containing a light source that enables skin structures invisible to the naked eye to be seen. A medium such as ultrasound gel or vaseline oil is applied to the skin to make the stratum corneum transparent (epiluminescence technique), and the dermatoscope lens is placed against the skin surface. The instrument makes it possible to observe a vast new range of dermatological signs. A limitation of the handheld dermatoscope is represented by maximum ×10 magnification. In addition, many devices do not allow image storage, although new models can be connected to photocameras or smartphones for storage and post-processing.

Dermatoscopy is currently used in routine dermatology. The various specialist courses held in recent years have led to the definition of new methods for improving the diagnosis of neoplastic and other skin disorders.

VIDEODERMATOSCOPY

ANALOG VIDEODERMATOSCOPY

Between 1980 and 1990, advances in video technology led to the development of instruments that displayed dermatoscopic images on a screen.¹ The first videodermatoscopes had a telecamera with video resolution connected to an optical dermatoscope and a television screen with video recorders to record examinations. They suffered from low quality due to the low resolution of the first video cameras and cumbersome documentation and data-saving procedures. Maximum television resolution is 768 × 576 pixel for the European PAL Broadcast system and less for the US National Television Systems Committee (NTSC) where pixel is the basic image unit; analog video recorders of the 1980s often had less than 400 horizontal lines. Low quality and technical limitations prevented the widespread use of videodermatoscopy.²

DIGITAL VIDEODERMATOSCOPY

Between 1990 and 2000, computerized instruments for digitizing images from telecameras connected to videodermatoscopes became common. Digital dermatoscopic images can be obtained by conversion from video-telecameras connected to digital cards or by use of high-resolution digital telecameras or digital cameras coupled with special dermatoscopy adaptors. Computerized systems proved more practical for managing examinations because they offered the possibility of saving personal and private data of patients together with digital images of pigmented skin lesions (Figure 1.1).^2–3

In the case of video-telecameras, the signal acquisition peripheral required a charge coupled device (3CCD) or sensor for the red, green, and blue bands, to keep image quality high during sampling.¹,⁴ Digital telecameras have better quality for the equivalent video characteristics because they do not require any conversion. They can have a USB (usually amateur grade) or Firewire (professional grade faster and better quality) interface. Much higher resolution is possible with digital telecameras than with analog video telecameras, and this has clear diagnostic advantages, as digital dermatoscopy systems of this type can reach 1280 × 1024 pixel with images observed in vivo at 15–25 photograms per second on computer screens (Figure 1.2). Digital cameras provide exceptionally high resolutions (up to 3000 × 2000 are common) but have the disadvantage of not providing full-resolution images in vivo but only after the images have been saved.

FIGURE 1.1 Digital videodermatoscope.

Figure 1.2 “Real-time” digital dermatoscopy analyzer.

The two types of digital instruments are therefore designed for different users. Clinicians who use video or digital telecameras (usually specialist centers) perform many examinations to diagnose melanoma or inflammatory skin diseases and observe many lesions by digital technology. Digital cameras are largely used to document lesions first observed by traditional dermatoscopy.⁵

It is commonly thought that a higher number of pixels implies better quality images; this is untrue, even if resolution is the imaging system’s ability to reproduce details. Image quality is determinant for early diagnosis of melanoma and depends on factors such as the optical system of the instrument, illumination, type of instrument, and resolution.⁶ Digital dermatoscopy images generally have between 768 × 576 and 1600 × 1200 pixel; lower resolution compromises diagnosis and higher resolution is unnecessary (Figure 1.3). The definition of magnification is only valid for integrated instruments with the same screens. Field of view is a preferable parameter. Dermatoscopy optical systems generally enable a horizontal field of view between 2 mm and 3 cm to be viewed. Overall magnification M of digital dermatoscopes is calculated as the ratio of screen diagonal D to field of view diagonal d: M = D/d.

Illumination must be homogeneous and sufficiently strong, while incident intensity should be modified by the lens diaphragm rather than by varying electrical potential, to keep the color of the study area constant. Reddish or saturated images result from low-quality equipment or failure to balance white chromatic calibration.

FIGURE 1.3 (a) Dermatoscopic image at 512 × 384 pixel resolution (42.8 KB). (b) The same image at 1024 × 768 pixel resolution (326 KB).

On the basis of the observation that in adult patients benign lesions remain stable whereas melanoma tends to grow and change over time, digital follow-up of melanocytic lesions has been proposed as a strategy to recognize melanoma. Stratification of the risk of developing melanoma is of great importance to establish the best strategies and follow-up methods. The intervals between successive dermatoscopy examinations vary. Most frequently the first checkup is performed 3 months after initial examination; further follow-up is performed every 12 months. Short-term follow-up is oriented toward assessment of single melanocytic lesions, while medium (every 6 months) and long-term (every 12 months) follow-up is focused on monitoring of multiple lesions. The lesions selected for short-term follow-up usually fall into two categories: moderately atypical lesions without a history of change and mildly atypical nevi with a history of change. Long-term follow-up is used for the surveillance of patients with atypical mole syndrome or high nevi count, among other risk factors. Short-term follow-up (after 3 months) may be the only way to recognize early melanoma.^7–8

CONTACT, NONCONTACT, AND POLARIZED DERMATOSCOPY

Today there are many types of dermatoscopes. Contact incident-light dermatoscopes use a glass window placed in contact with the skin, illuminated at an angle of about 30–45 degrees so as to eliminate direct reflection, and a magnifying lens system.⁹ A liquid fills the space between the skin and the glass, rendering the skin translucent and revealing subcutaneous patterns invisible to the naked eye.^9–11

Two polarizing filters can be added to this simple optical system, one before the telecamera sensor and one on the light source, to eliminate light reflected by cross-polarization. Light reflected from the skin surface maintaining the polarization of the light source is eliminated by the polarizer in front of the sensor; this enables skin patterns to be observed to a greater depth. Pol...

Table of contents

• Cover
• Half Title
• Title Page
• Copyright Page
• Table of Contents
• Introduction
• List of contributors
• 1 Equipment for dermatoscopy/videodermatoscopy
• 2 Parasitoses: Scabies
• 3 Parasitoses: Pediculosis
• 4 Parasitoses: Therapeutic monitoring of scabies and pediculosis
• 5 Parasitoses: Tungiasis
• Parasitoses: Cutaneous larva migrans
• 7 Parasitoses: Cutaneous leishmaniasis
• 8 Parasitoses: Trombiculiasis
• 9 Infectious diseases: Cutaneous and genital warts
• 10 Infectious diseases: Molluscum contagiosum
• 11 Infectious diseases: Tinea capitis
• 12 Hair loss and hair shaft disorders
• 13 Inflammatory diseases: Psoriasis
• 14 Inflammatory diseases: Lichen planus
• 15 Inflammatory diseases: Common urticaria and urticarial vasculitis
• 16 Inflammatory diseases: Connective tissue diseases
• 17 Inflammatory diseases: Rosacea
• 18 Inflammatory diseases: Pigmented purpuric dermatoses
• 19 Inflammatory diseases: Pityriasis lichenoides
• 20 Inflammatory diseases: Granulomatous skin disorders and Wolf’s isotopic response lesions
• 21 Nonpigmented skin lesions: Clear cell acanthoma
• 22 Nonpigmented skin lesions: Pyogenic granuloma
• 23 Nonpigmented skin lesions: Angiokeratoma
• 24 Nonpigmented skin lesions: Sebaceous hyperplasia
• 25 Nonpigmented skin lesions: Xanthomatous lesions
• 26 Nonpigmented skin lesions: Porokeratosis
• 27 Nonpigmented skin lesions: Apocrine hidrocystoma
• 28 Nonpigmented skin lesions: Bowen’s disease
• 29 Nonpigmented skin lesions: Actinic keratosis and squamous cell carcinoma
• 30 Capillary malformations
• 31 Miscellaneous disorders
• 32 Photodamaged and aged skin
• Index