The Target of Penicillin

The Murein Sacculus of Bacterial Cell Walls Architecture and Growth. Proceedings International FEMS Symposium Berlin (West), Germany, March 13–18, 1983

R. Hakenbeck, J. V. Höltje, H. Labischinski

• Publisher: De Gruyter
• Year: 2019
• Print ISBN: 9783110097054
• eBook ISBN: 9783110866544
• Edition: 1
• Topic: Biological Sciences
• Subtopic: Biochemistry
• Index: Biological Sciences

Table of contents

• Preface
• CONTENTS
• CONTRIBUTORS AND PARTICIPANTS
• INTRODUCTION
• THE BACTERIAL CELL WALL - STRUCTURE AND FUNCTION
• PART I. PRIMARY AND THREE DIMENSIONAL STRUCTURE OF MUREIN
• PRIMARY STRUCTURES OF MUREIN AND PSEUDOMUREIN
• STRUCTURE OF THE PEPTIDOGLYCAN OF THE CYANOBACTERIUM SYNECHOCYSTIS PCC 6714
• CHARACTERIZATION OF MUROPEPTIDES RELEASED FROM MUREIN OF CAULO-BACTER CRESCENTUS BY ENDO-N-ACETYLMURAMIDASE
• THE ANALYSIS OF MUREIN COMPOSITION WITH HIGH-PRESSURE-LIQUID CHROMATOGRAPHY
• THE ANIONIC NATURE AND SOME PERMEABILITY CHARACTERISTICS OF MUREIN
• ELECTROCHEMICAL AND MECHANICAL INTERACTIONS IN BACILLUS SPORE AND VEGETATIVE MUREINS
• THE STATE OF ORDER OF BACTERIAL PEPTIDOGLYCAN
• A THREE DIMENSIONAL MODEL OF THE MUREIN LAYER EXPLAINING ONE STEP OF ITS BIOSYNTHESIS BY SELF-ASSEMBLY
• COMPUTER AIDED MOLECULAR MODELLING OF THE THREEDIMENSIONAL STRUCTURE OF BACTERIAL PEPTIDOGLYCAN
• COMPARISON BETWEEN THE SUGAR CHAIN CONFORMATION IN MUREIN AND PSEUDOMUREIN
• THE CONFORMATIONAL BEHAVIOUR OF THE PEPTIDE PART OF MUREIN - AN INFRARED AND RAMAN SPECTROSCOPIC STUDY
• DYNAMIC ASPECTS OF BACTERIAL CELL WALLS PROBED BY IN VIVO ¹⁵N NMR
• A NOVEL AND RAPID METHOD FOR IDENTIFYING IMPORTANT CELL WALL PARAMETERS: FOURIER-TRANSFORM INFRARED SPECTROSCOPY
• CALORIMETRIC STUDIES ON THE BINDING OF VANCOMYCIN - LIKE ANTIBIOTICS TO PEPTIDOGLYCAN
• PART II. MODELS FOR THE GROWTH OF THE MUREIN SACCULUS
• THE SHAPES OF GRAM-NEGATIVE ORGANISMS: VARI ABLE-T MODELS
• MUREIN RING STRICTURE AND BIOSYNTHESIS IN GRAM-NEGATIVE BACTERIA: SOME TENTATIVE CONTEMPLATIONS
• REGULATION OF THE INITIA1ICN AND OCMPLETICK OF ENVELOPE GRCWIH SITES IN STREPTOCOCCUS FAECIUM (ATCC 9790)
• A NEW MODEL FDR GROWTH OF THE MUREIN SACCULUS
• PEPTIDE CROSSBRIDGES IN THE MUREIN OF ESCHERICHIA COLI ARE BROKEN AND REFORMED AS THE BACTERIUM GROWS
• A NOVEL HYPOTHESIS TO EXPLAIN REGULATION OF THE MUREIN SACCULUS SHAPE
• GENERAL PROPERTIES OF TEMPERATURE-SENSITIVE CELL DIVISION MUTANTS OF STREPTOCOCCUS FAECIUM
• PREMATURE DIVISION IN ESCHERICHIA COLI IN THE PRESENCE OF TRIS-EDTA
• PART III. FUNCTION OF MUREIN HYDROLASES AND CONTROL OF MUREIN DEGRADATION
• MUREIN HYDROLASES - ENZYMES IN SEARCH OF A PHYSIOLOGICAL FUNCTION?
• THE AUTOLYTIC SYSTEM OF STREPTOCOCCUS FAECIUM
• INTERACTION BETWEEN CHOLINE AND THE N-ACETYL-MURAMYL-L-ALANINEAMIDASE OF STREPTOCOCCUS PNEUMONIAE
• THE INFLUENCE OF LIPOTEICHOIC ACIDS ON THE AUTOLYTIC ACTIVITY OF STAPHYLOCOCCUS AUREUS
• COENZYME A-GLUTATHIONE DISULFIDE: AN ENDOGENOUS INHIBITOR OF THE LYTIC ENZYMES IN ESCHERICHIA COLI
• AUTOLYSIS OF ESCHERICHIA COLI INDUCTION AND CONTROL
• EXPRESSION OF ØX174 LYSIS GENE CLONED INTO DIFFERENT PLASMIDS
• LOCALISATION OF THE BACTERIOPHAGE ØX1.74 LYSIS GENE PRODUCT IN THE CELL ENVELOPE OF ESCHERICHIA COLI
• INDUCTION OF CELL LYSIS BY MECILLINAM PLUS NOCARDICIN A: ISOLATION AND PROPERTIES OF A TOLERANT MUTANT
• INCREASED WALL AUTOLYSIS AND DECREASED PEPTIDOGLYCAN CROSSLINKING IN METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS GROWN IN THE PRESENCE OF METHICILLIN
• MORPHOLOGICAL STUDY OF THERMOSENSITIVE LYSIS MUTANTS OF BACILLUS SUBTILIS
• CHARACTERISTICS OF TOLERANT GROUP A STREPTOCOCCI
• CELL WALL METABOLISM IN LYT-MUTANTS OF BACILLUS SUBTILIS
• RESTORATION OF PENICILLIN-DAMAGED CELL WALLS BY DE NOVO MUREIN SYNTHESIS AND SUCCESSIVE MUREIN DEGRADATION IN STAPHYLOCOCCI, REVEALING A HITHERTO UNKNOWN MECHANISM OF PENICILLIN ACTION: BLOCKAGE OF AUTOLYTIC WALL PROCESSES BY PENICILLIN
• β-LACTAM ANTIBIOTICS DO NOT TRIGGER THE ACTIVITIES OF AUTOLYSINS IN ETHER PERMEABILIZED ESCHERICHIA COLI
• O-ACETYLATION AND HYDROLASES OF GONOCOCCAL PEPTIDOGLYCAN
• ACETYLATION IN DIFFERENT PHASES OF GROWTH OF STAPHYLOCOCCI AND THEIR RELATION TO CELL WALL DEGRADABILITY BY LYSOZYME
• EFFECT OF PENICILLIN"AND CHLORAMPHENICOL-TREATMENT ON THE MUREIN IN STREPTOCOCCUS PNEUMONIAE : ALTERATION IN STRUCTURE AND SUSCEPTIBILITY TO MUREIN HYDROLASES
• MICROCALORIMETRIC AND ELECTRON MICROSCOPIC INVESTIGATION ON STAPHYLOCOCCI BEFORE AND AFTER TREATMENT WITH PENICILLIN AND CHLORAMPHENICOL AND THEIR COMBINATIONS
• CORRELATION OF CELL WALL TURNOVER AND AUTOLYTIC ACTIVITY IN FLA AND SUPERMOTILE MUTANTS OF BACILLUS SUBTILIS
• B. SUBTILIS W23/168 RECOMBINANTS WITH HYBRID CELL WALLS AND PHAGE RESISTANCE PATTERNS
• PART IV. BIOLOGICAL PROPERTIES AND MEDICAL ASPECTS OF MUREIN
• IMMUNOMODULATING PROPERTIES OE NATURAL AND SYNTHETIC MUROPEPTIDES
• THE IMMUNOCHEMISTRY OF PEPTIDOGLYCAN
• A NEW MUREIN HYDROLASE IN HUMAN SERUM
• LYSOZYME-RESISTANT Q-ACETYLATED PEPTIDOGLYCAN OF NEISSERIA GONORRHOEAE : STRAIN VARIATION, RESISTANCE TO HUMAN PEPTIDOGLYCAN HYDROLASES, AND PATHOBIOLOGICAL PROPERTIES
• THE INFLUENCE OF DIFFERENT ANTIBIOTICS ON THE DEGREE OF O-ACETYLATION OF STAPHYLOCOCCAL CELL WALLS
• CELL WALL DEGRADATION OF STAPHYLOCOCCUS AUREUS BY AUTOLYSINS AND LYSOZYME
• CELL WALL DEGRADATION OF ANTIBIOTIC-TREATED STAPHYLOCOCCI UNDER PHAGOCYTE-SPECIFIC CONDITIONS: Distinction between Penicillin-Induced Lytic Effects and Wall Alterations Caused by Anticoagulants
• INDUCED AUTOLYTIC WALL PROCESSES IN HEAT-INACTIVATED STAPHYLOCOCCUS AUREUS
• CATIONIC POLYELECTROLYTES ACTIVATE AUTOLYTIC WALL ENZYMES IN STAPHYLOCOCCUS AUREUS: Modulation by anionic polyelectrolytes in relation to the survival of bacterial constituents in tissues
• PART V. STRUCTURE AND FUNCTION OF PENICILLIN-BINDING PROTEINS
• PENICILLIN BINDING PROTEINS AS TARGETS OF THE LETHAL EFFECTS OF β-LACTAM ANTIBIOTICS
• BINDING SPECIFICITIES OF PENICILLIN BINDING PROTEINS - A CONFORMATIONAL APPROACH
• THE ACTIVE SITES OF THE D-ALANYL-D-ALANINE-CLEAVING PEPTIDASES
• X-RAY STRUCTURE OF A PENICILLIN TARGET ENZYME
• THE FINE ARCHITECTURE AND FUNCTION OF THE GENE CODING FOR PBP-3 OF ESCHERICHIA COLI
• SEQUENCE OF PENICILLIN-BINDING PROTEIN 5 OF ESCHERICHIA COLI
• PURIFICATION AND IDENTIFICATION OF THE Pseudomonas aeruginosa DD-ENDOPEPTIDASE AS A PENICILLIN-BINDING PROTEIN
• PURIFICATION OF PENICILLIN BINDING PROTEINS FROM STREPTOCOCCUS PNEUMONIAE
• CHARACTERIZATION OF PENICILLIN BINDING PROTEINS FROM STREPTOCOCCUS PNEUMONIAE BY PROTEOLYSIS
• DISTRIBUTION OF PENICILLIN-BINDING PROTEINS WITHIN THE CELL ENVELOPE OF Escherichia coli
• LABELLING AND CROSS-LINKING OF E. COLI PBPs WITH BIS-B-LACTAM AND PHOTOREACTIVE DERIVATIVES OF B-LACTAM ANTIBIOTICS
• TOPOLOGICAL INTERRELATION OF PENICILLIN-BINDING PROTEINS IN E. COLI - A STUDY USING CLEAVABLE CROSS-LINKERS
• ELECTROFOCUSING OF INTEGRAL BACTERIAL MEMBRANE PROTEINS WITH SPECIAL REGARD TO PBPs.
• CHARACTERIZATION OF THE CHANGES IN PENICILLIN-BINDING PROTEINS THAT OCCUR DURING SPORULATION OF BACILLUS SUBTILIS
• PATTERN OF PENICILLIN-BINDING PROTEINS DURING THE LIFE CYCLE OF ESCHERICHIA COLI
• GROWTH DEPENDENT MODIFICATIONS OF THE PENICILLIN BINDING PROTEINS OF Escherichia coli : INFORMATION SUPPORTING THE GENERALITY OF THE PROCESS AND THE MULTIPLICITY OF MECHANISMS
• RECOMBINANT PLASMIDS CARRYING PENICILLIN-BINDING PROTEIN/CELL SHAPE GENES FROM THE lip-leuS REGION OF THE ESCHERICHIA COLI CHROMOSOME
• SOME ASPECTS OF THE MECHANISM OF EXPRESSION OF PBP 3 IN E.coli
• THE INTERDEPENDENCE OF BACTERIAL SHAPE AND SIMULTANEOUS BLOCKING OF PBP 2 AND 3 IN ESCHERICHIA COLI SP 45 AND ESCHERICHIA COLI SP 63
• BENZYLPENICILLIN-RESISTANT MUTANTS OF CLOSTRIDIUM PERFRINGENS
• STUDIES OF ß-LACTAM RESISTANCE IN STREPTOCOCCUS FAECIUM
• BIOSYNTHESIS OF MUREIN (PEPTIDOGLYCAN)
• ENZYMATIC SYNTHESIS OF PEPTIDOGLYCAN-CROSSBRIDGES IN E. COLI
• NEW INSIGHTS IN THE PROCESS OF IN VITRO MUREIN SYNTHESIS IN E. COLI REVEALED BY MUREIN-ANALYSIS WITH HIGH-PRESSURE-LIQUIDCHROMATOGRAPHY
• PENICILLIN-BINDING PROTEINS AND PEPTIDOGLYCAN BIOSYNTHESIS IN BACILLUS MEGATERIUM
• FUNCTION OF PENICILLIN-BINDING PROTEIN 3 IN STREPTOCOCCUS FAECIUM
• THE ROLE OF A PROTEIN THAT BINDS PENICILLIN WITH SLOW KINETICS IN PHYSIO LOGY AND RESPONSE TO PENICILLIN OF STREPTOCOCCUS FAECIUM ATCC 9790
• TRANSPEPTIDATION IN STAPHYLOCOCCUS AUREUS WITH INTRINSIC RESISTANCE TO ß-LACTAM ANTIBIOTICS ("METHICILLIN RESISTANCE")
• PENICILLIN-SENSITIVE ENZYMES IN STAPHYLOCOCCUS AUREUS
• VI. BIOSYNTHESIS OF MUREIN
• PEPTIDOGLYCAN BIOSYNTHESIS : CONTROL OF PRECURSOR SYNTHESIS AND INTERMEDIATES IN ASSEMBLY
• CYTOPLASMIC STEPS OF PEPTIDOGLYCAN SYNTHESIS IN E. coli K 12
• EFFECT OF DRUGS ON THE FORMATION AND STRUCTURE OF INTERMEDIATES OF ESCHERICHIA COLI MUREIN BIOSYNTHESIS
• THE EFFECT OF 6-LACTAM ANTIBIOTICS ON MUREIN SYNTHESIS IN ETHER TREATED ESCHERICHIA COLI
• COMPARISON OF THE EFFECTS ON MUREIN SYNTHESIS OF ß-LACTAM ANTIBIOTICS AND D-AMINO ACIDS
• Hildegard Criegee and Walter P. Hammes
• BIOSYNTHESIS OF PEPTIDOGLYCAN IN GAFFKYA HOMARI: Processing of nascent glycan by reactivated membranes
• THE INHIBITION OF IN VITRO SYNTHESIS OF MUREIN IN GAFFKYA HOMARI BY MONOCYCLIC ß-LACTAM ANTIBIOTICS NOCARDICIN B,E AND AZTHREONAM
• PEPTIDOGLYCAN SYNTHESIS IN VITRO BY PARTICULATE PREPARATION FROM Streptococcus sangui s 34
• SYNTHESIS OF PEPTIDOGLYCAN FROM EXTEENALLY SUPPLIED PBECUESOES BY PARTLY AUTOLYSED CELLS OP Bacillus subtilis W23
• O-ACETYLATION OF MURAMIC ACID, BIOSYNTHESIS OF MUREIN AND THE EFFECT OF PENICILLIN G IN VIVO IN SYNCHRONIZED CELLS OF PROTEUS MIRABILIS
• PEPTIDOGLYCAN SYNTHESIS AND TURNOVER IN BACILLUS SUBTILIS
• POTENTIAL SITES FOR THE COORDINATE CONTROL OF MUREIN AND TEICHOIC ACID BIOSYNTHESIS IN S. PNEUMONIAE
• MECHANISM OF STRINGENT CONTROL OF PEPTIDOGLYCAN SYNTHESIS IN ESCHERICHIA COLI
• INTERRELATIONSHIPS BETWEEN WALL AND MEMBRANE BIOSYNTHESIS
• FUNCTIONAL DOMAINS OF COLICIN M
• Author Index
• Subject Index