Freeze-Drying/Lyophilization of Pharmaceutical and Biological Products
eBook - PDF

Freeze-Drying/Lyophilization of Pharmaceutical and Biological Products

  1. 584 pages
  2. English
  3. PDF
  4. Available on iOS & Android
eBook - PDF

Freeze-Drying/Lyophilization of Pharmaceutical and Biological Products

About this book

Freeze-drying, or lyophilization, is a well established technology used in the preservation of numerous pharmaceutical and biological products. This highly effective dehydration method involves the removal of water from frozen materials via the direct sublimation of ice. In recent years, this process has met with many changes, as have the regulatio

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Yes, you can access Freeze-Drying/Lyophilization of Pharmaceutical and Biological Products by Louis Rey in PDF and/or ePUB format, as well as other popular books in Medicine & Pharmacology. We have over one million books available in our catalogue for you to explore.

Information

Publisher
CRC Press
Year
2016
Print ISBN
9780367248192
eBook ISBN
9781439825761
Edition
3
Topic
Medicine
Subtopic
Pharmacology

Table of contents

  1. Front Cover
  2. Contents
  3. Foreword
  4. Preface
  5. Contributors
  6. Chapter 1 Glimpses into the Realm of Freeze-Drying: Classical Issues and New Ventures
  7. Chapter 2 Structural and Dynamic Properties of Bulk and Confined Water
  8. Chapter 3 Freezing and Annealing Phenomena in Lyophilization
  9. Chapter 4 Phase Separation of Freeze-Dried Amorphous Solids: The Occurrence and Detection of Multiple Amorphous Phases in Pharmaceutical Systems
  10. Chapter 5 The Use of Microscopy, Thermal Analysis, and Impedance Measurements to Establish Critical Formulation Parameters for Freeze-Drying Cycle Development
  11. Chapter 6 The Relevance of Thermal Properties for Improving Formulation and Cycle Development: Application to Freeze-Drying of Proteins
  12. Chapter 7 Freezing-and Drying-Induced Perturbations of Protein Structure and Mechanisms of Protein Protection by Stabilizing Additives
  13. Chapter 8 Mechanisms of Protein Stabilization During Freeze-Drying Storage: The Relative Importance of Thermodynamic Stabilization and Glassy State Relaxation Dynamics
  14. Chapter 9 Formulation Characterization
  15. Chapter 10 Practical Aspects of Freeze-Drying of Pharmaceutical and Biological Products Using Nonaqueous Cosolvent Systems
  16. Chapter 11 Regulatory Control of Freeze-Dried Products: Importance and Evaluation of Residual Moisture
  17. Chapter 12 Freeze-Drying of Biological Standards
  18. Chapter 13 Molecular Mobility of Freeze-Dried Formulations as Determined by NMR Relaxation Times, and Its Effect on Storage Stability
  19. Chapter 14 Scanning Electron Microscopy: A Powerful Tool for Imaging Freeze-Dried Material
  20. Chapter 15 Pharmaceutical Packaging for Lyophilization Applications
  21. Chapter 16 Closure and Container Considerations in Lyophilization
  22. Chapter 17 Extractables and Leachables as Container Closure Considerations in Lyophilization
  23. Chapter 18 Optimizing the Throughput of Freeze-Dryers Within a Constrained Design Space
  24. Chapter 19 Monitoring and Control of Industrial Freeze-Drying Operations: The Challenge of Implementing Quality-by-Design (QbD)
  25. Chapter 20 Process Analytical Technology in Industrial Freeze-Drying
  26. Chapter 21 Practical Considerations for Freeze-Drying in Dual Chamber Package Systems
  27. Chapter 22 Lyophilization and Irradiation as an Integrated Process
  28. Appendix: Table, Saturation Vapor Pressure Of Ice
  29. Index