| 1619 | First African Americans in Virginia. |
| 1776, 4 July | Declaration of Independence. |
| 1787 | Constitution of the United States of America. |
| 1787 | North-West Ordinances: slavery banned from North-West territory. |
| 1816 | American Colonisation Society established. |
| 1820 | Missouri Compromise: prohibited slavery north of 36°30Ⲡin territory of Louisiana Purchase. |
| 1831, 1 January | First number of Garrisonās Liberator. |
| 1831, 13ā23 August | Nat Turnerās slave revolt, Southampton County, Virginia. |
| 1831ā32 | Debates in Virginia legislature. Narrow defeat of emancipation and state black codes reinforced. |
| 1832 | South Carolina State Convention nullifies federal tariffs of 1828 and 1832. |
| 1832, 5 December | Jackson re-elected president. |
| 1832, 10 December | Jackson issues a proclamation to people of South Carolina against nullification. |
| 1833 | Oberlin, Americaās first co-educational college, established and, under Theodore Weld, became centre of north-west abolitionism; American Antislavery Society established in Philadelphia; slavery and slave trade ended in British Empire. |
| 1834 | Prudence Crandallās school for African American girls in Canterbury, Connecticut, closed by vandalism. |
| 1835, 21 October | Mob attacks female Antislavery Society meeting in Boston, and Garrison is nearly killed. |
| 1836, March | Texas declares independence from Mexico. |
| 1836, 11 March | A āgag ruleā introduced in Congress barring discussion of anti-slavery petitions (repealed 1844). |
| 1837, May | Economic panic and depression; Martin Van Buren 8th President of the United States. |
| 1837, 7 November | Abolitionist editor, Elijah Lovejoy, murdered by mob in Alton, Illinois; Emersonās address at Harvard, āThe American Scholarā, declaring American literary independence from Europe. |
| 1838 | Joshua Giddings (Ohio, Whig) first abolitionist in Congress; first American edition of Tocquevilleās Democracy in America. |
| 1839 | Theodore Weldās Slavery as It Is; Armistad slave mutiny. |
| 1840 | Harrisonās āLog cabin and hard ciderā campaign; World Antislavery Convention held in London, and women denied seating on floor of hall; Liberty Party organised and nominated James Birney as presidential candidate. |
| 1841 | William Henry Harrison 9th President of the United States. |
| 1841, 4 April | John Tyler (previously Vice President) becomes 10th President of the United States; Brook Farm, utopian communal experiment, established in Massachusetts by George Ripley. |
| 1842 | Prigg v. Pennsylvania. |
| 1843 | Baptist church split over slavery. |
| 1844 | James Polk stands on platform of annexation of Texas and acquisition of Oregon territory. |
| 1845, December | Texas admitted as 28th state and 15th slave state; Douglassās Narrative of the Life of Frederick Douglass: An American Slave. |
| 1846, 13 May | Congress declares war on Mexico. |
| 1846, 15 June | Settlement of Oregon boundary at the 49th Parallel. |
| 1846, June | FrƩmont leads Bear Flag revolt in California against Mexico; David Wilmot (Pennsylvania, Democrat) Proviso excluding slavery from any territory acquired from Mexico fails in Senate. |
| 1847, 23 February | General Zachary Taylor defeats Mexicans at Buena Vista. |
| 1847, 14 September | Winfield Scott captures Mexico City. |
| 1848, 24 January | Gold discovered at Sutterās Mill, California. Start of California Gold Rush. |
| 1848, 2 February | Treaty of Guadalupe Hidalgo with Mexico. |
| 1848, 19ā20 July | First female rightsā convention held at Seneca Falls, New York State; Free Soil Party established with Martin Van Buren as presidential candidate. |
| 1848 | Zachary Taylor elected 12th President of the United States. |
| 1849 | Thoreau, Resistance to Civil Government. |
| 1850, 9 July | Death of Taylor. Vice President Millard Fillmore becomes 13th President of the United States. |
| 1850, 9 September | California established as 31st and free state. Great Compromise of 1850. |
| 1851 | Melville, Moby Dick. |
| 1852 | Publication of Harriet Beecher Stoweās Uncle Tomās Cabin. |
| 1853 | Franklin Pierce 14th President of the United States. |
| 1853, July | Commodore Matthew Perryās mission to Japan. |
| 1854 | KansasāNebraska Act repeals Missouri Compromise. |
| 1854, 28 February | Founding of Republican Party in Ripon, Wisconsin; Thoreau, Walden or Life In The Woods; George Fitzhugh, Sociology for the South. |
| 1855 | Civil war in āBleeding Kansasā. |
| 1855, 28 April | Massachusetts bans segregation in education; Whitman, Leaves of Grass. |
| 1856 | John Brown and 7 followers massacre 5 pro-slavers at Pottawatomie Creek; Sumnerās āCrime against Kansasā speech, followed by assault upon him in Senate two days later. |
| 1857 | Buchanan 15th President of the United States. |
| 1857, November | Buchanan accepts pro-slavery Lecompton Constitution for Kansas. Douglas rejects it. Democratic split. |
| 1858, 16 June | Lincolnās āHouse Dividedā speech at Illinois Republican state convention. |
| 1858, 21 Augustā15 October | LincolnāDouglas Debates in Illinois; Sewardās āIrrepressible Conflictā speech at Rochester. |
| 1859, 16 October | John Brownās raid on Harperās Ferry. Executed 2 December. |
| 1860, 6 November | Lincoln elected 16th President of the United States. |
| 1860, 20 December | South Carolina secedes, followed rapidly by 6 other slave states. |
| 1860, 31 December | Crittenden Amendment rejected by Senate Committee. |
| 1861, 8 February | ... |