Handbook of Assay Development in Drug Discovery
eBook - PDF

Handbook of Assay Development in Drug Discovery

  1. 488 pages
  2. English
  3. PDF
  4. Available on iOS & Android
eBook - PDF

Handbook of Assay Development in Drug Discovery

About this book

The Handbook of Assay Development in Drug Discovery describes all the tools currently available for performing various assay techniques. Featuring troubleshooting advice for common problems from experienced assay developers, the vendor community, and scientists in the pharmaceutical industry, the book presents descriptions of methods, laboratory guidelines and protocols used to perform such methods, specific examples of each assay system, and troubleshooting tools. Designed as a guide to running an assay from start to finish, this is an ideal bench top companion for scientists involved in drug discovery screening, lead profiling, therapeutic target evaluation, and assay development and implementation.

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Yes, you can access Handbook of Assay Development in Drug Discovery by Lisa K. Minor in PDF and/or ePUB format, as well as other popular books in Medicine & Pharmacology. We have over one million books available in our catalogue for you to explore.

Information

Publisher
CRC Press
Year
2006
Print ISBN
9780367269890
eBook ISBN
9781420015706
Edition
1
Topic
Medicine
Subtopic
Pharmacology

Table of contents

  1. Front cover
  2. Dedication
  3. Preface
  4. Editor
  5. Contributors
  6. Table of Contents
  7. Chapter 1. Protein Kinases in Drug Discovery: Rationale, Success, and Challenge
  8. Chapter 2. An Introduction to the Protein Tyrosine Phosphatase Gene Family and Screening Assay Development
  9. Chapter 3. Time-Resolved Flourescence Based Assays for Kinases
  10. Chapter 4. Development of High-Throughput Screening Assays in Scintillating Microplates (FlashPlates) to Identify Inhibitors of Kinase Activity
  11. Chapter 5. Development of High-Throughput Screening Assays for Kinase Drug Targets Using AlphaScreen Technology
  12. Chapter 6. Homogeneous High-Throughput Screening (HTS) Assays for Serine/Threonine Kinases Using -Galactosidase Enzyme Fragment Complementation
  13. Chapter 7. IMAP Assays for Protein Kinases
  14. Chapter 8. A Homogeneous, Luminescent, High-Throughput, Versatile Assay for a Wide Range of Kinases
  15. Chapter 9. Proteases as Drug Targets
  16. Chapter 10. A Comparison of Homogeneous Bioluminescent and Fluorescent Methods for Protease Assays
  17. Chapter 11. Scintillation Proximity Assay (SPA) Receptor Binding Assays
  18. Chapter 12. Radioligand Binding Filtration Assay: Full Automation
  19. Chapter 13. Nuclear Receptors as Drug Targets
  20. Chapter 14. Nuclear Receptor Scintillation Proximity Assays
  21. Chapter 15. Homogeneous Assay Development for Nuclear Receptor Using AlphaScreen Technology
  22. Chapter 16. Development of Nuclear Receptor Homogeneous Assay Using the LANCE Technology
  23. Chapter 17. The Emerging Role of Cell-Based Assays in Drug Discovery
  24. Chapter 18. The Preparation of Cells for High-Content Screening
  25. Chapter 19. The Evolution of cAMP Assays
  26. Chapter 20. A Homogeneous, Fluorescent Polarization Assay for Inositol 1,4,5-Trisphosphate (Ins P )
  27. Chapter 21. Scintillation Proximity Assay of Inositol Phosphates
  28. Chapter 22. Measuring Calcium Mobilization with G -Coupled GPCRs Using the Fluormetric Imaging Plate Reader (FLIPR)
  29. Chapter 23. Development of FLIPR-Based HTS Assay for G;-Coupled GPCRs
  30. Chapter 24. Aurora Assays
  31. Chapter 25. Membrane Potential Based Assays for Ion Channels and Electrogenic Transporters
  32. Chapter 26. Reporter Gene Assays for Drug Discovery
  33. Chapter 27. mRNA Detection from Cells Using Quantigene Branched DNA Technology
  34. Chapter 28. Homogeneous Multiwell Assays for Measuring Cell Viabiltiy, Cytotoxicity, and Apoptosis
  35. Chapter 29. Development of Image-Based Assays for Drug Discovery
  36. Chapter 30. GPCR Internalization Measured by Image Analysis
  37. Chapter 31. TRANSFLUOR Provides a Universal Cell-Based Assay for Screening G-Protein-Coupled Receptors
  38. Index
  39. Back cover