- 718 pages
- English
- PDF
- Available on iOS & Android
eBook - PDF
About this book
DNA repair is a rapidly advancing field in biology and these systems represent a major defense mechanism against environmental and intracellular damaging agents such as sunlight, ionizing radiation, and reactive oxygen species. With contributions from eminent researchers, this book explores the basics and current trends in this critical field. Topi
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Yes, you can access DNA Repair and Cancer by Srinivasan Madhusudan,David M. Wilson III in PDF and/or ePUB format, as well as other popular books in Medicine & Oncology. We have over one million books available in our catalogue for you to explore.
Information
Table of contents
- Front Cover
- Contents
- Biography
- Foreword
- Introduction
- 1. Overview of DNA Repair Pathways
- 2. Longevity Assurance by Genome Maintenance
- 3. Genetic Instability of Cancer: Biological Predictions and Clinical Implications
- 4. Radiation Induced DNA Damage, Repair and Therapeutics
- 5. Chemotherapeutic Alkylating Agents in Cancer Treatment
- 6. O6-Methylguanine-DNA Methyltransferase (MGMT) in Cancer Protection and Therapy
- 7. DNA Mismatch Repair: Its Role in Human Carcinogenesis and as a Predictive and/or Prognostic Biomarker for Cancer Therapy
- 8. DNA Base Excision Repair Therapeutics: Summary of Targets with a focus on APE1
- 9. Nucleotide Excision Repair: DNA Repair Capacity Variability and Cancer Susceptibility
- 10. Fanconi Anemia, Interstrand Cross-Link Repair, and Cancer
- 11. Functions of Translesion DNA Polymerases: Implications for Cancer Risk and Opportunities as Therapeutic Targets
- 12. p53 in DNA Damage, Repair and Cancer Therapeutics
- 13. ATM/ATR Cell Cycle Checkpoints: Mechanisms and Manipulation in Cancer Therapy
- 14. The BRCA1-BRCA2 Pathway of Homologous Recombination and the Opportunity for Synthetic Lethal Approaches to Cancer Therapy
- 15. PARP and PARP Inhibitor Therapeutics
- 16. Tumor Genetics and Personalized Medicine
- 17. The Tumor Microenvironment and DNA Repair: Implications for Cancer Progression and Treatment
- 18. Early Phase Clinical Trials Using DNA Repair Inhibitors: Lessons Learnt
- Color Plate Section