As pharmaceutical companies strive to develop safer medicines at a lower cost, they must keep pace with the rapid growth of technology and research methodologies. Defying the misconception of process chemistry as mere scale-up work, Process Chemistry in the Pharmaceutical Industry, Vol. 2: Challenges in an Ever Changing Climate explor

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Yes, you can access Process Chemistry in the Pharmaceutical Industry, Volume 2 by Kumar Gadamasetti, Tamim Braish, Kumar Gadamasetti,Tamim Braish in PDF and/or ePUB format, as well as other popular books in Physical Sciences & Chemistry. We have over one million books available in our catalogue for you to explore.

Information

Publisher

Year

Print ISBN

eBook ISBN

Edition

Topic

Physical Sciences

Subtopic

Chemistry

Index

Chemistry

Front cover
Table of Contents
Preface
Acknowledgments
The Editors
Contributors
Affiliations
Chapter 1. Process Chemistry in the Pharmaceutical Industry: Challenges in an Ever Changing Climate—An Overview
Chapter 2. Emerging Trends in Process Chemistry
Chapter 3. Varenicline: Discovery Synthesis and Process Chemistry Developments
Chapter 4. The SUTENT® Story
Chapter 5. An Efficient and Scalable Process for the Preparation of a Potent MC4 Receptor Agonist
Chapter 6. Process Research and Development of LY414197, a 5HT 2B Antagonist
Chapter 7. To Overcome the Hurdles: Coping with the Synthesis of Robalzotan, a Complex Chroman Antidepressant*
Chapter 8. Chiral Amine Synthesis—Strategies, Examples, and Limitations
Chapter 9. Unnatural Amino Acids
Chapter 10. The Chemical Development of a Potential Manufacturing Route to the Endothelin Antagonists UK-350,926 and UK-349,862
Chapter 11. Cefovecin Sodium: A Single- Dose Long-Acting Antibiotic for Use in Companion Animals
Chapter 12. The Lithium–Halogen Exchange Reaction in Process Chemistry
Chapter 13. Oxetan-3-one: Chemistry and Synthesis
Chapter 14. Well-Defined (NHC)Pd (II) Complexes and Their Use in C–C and C–N Bond-Forming Reactions
Chapter 15. Toward Truly Efficient Organic Reactions in Water
Chapter 16. The Chemical Development of the Commercial Route to Sildenafil Citrate
Chapter 17. Stereoselective Enzymatic Synthesis of Intermediates Used for Antihypertensive, Antiinfective, and Anticancer Compounds
Chapter 18. Designing Robust Crystallization Processes for Active Pharmaceutical Ingredients—From Art to Science
Chapter 19. Mid-Infrared Spectroscopy for Process Development
Chapter 20. Optimizing an Asymmetric Homologation in a Tandem Asymmetric Homologation–Homoaldol Process
Chapter 21. Development of Efficient One- Pot Process in the Synthesis of Sitagliptin: Application of Online-Infrared for Kinetic Studies to Probe the Reaction Mechanism
Chapter 22. Mid-Infrared Monitoring Applications during Development of the Vinyl Ether Formation Step in the Preparation of Aprepitant (Emend)
Chapter 23. Process Analytical Technology in the Manufacture of Bulk Active Pharmaceuticals— Promise, Practice, and Challenges
Chapter 24. PEGylation of Biological Macromolecules
Chapter 25. Microwave Technology in Process Optimization
Chapter 26. Process Development Considerations for Therapeutic Monoclonal Antibodies in Mammalian Cell Culture
Chapter 27. Reaction Progress Kinetic Analysis: A Powerful Methodology for Streamlining Pharmaceutical Reaction Steps
Chapter 28. Trends in Outsourcing
Chapter 29. Sourcing Pharmaceutical Products in China and India
Index
Back cover

About this book

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Table of contents