Nucleosides exhibit a broad spectrum of biological activity that generally results from their ability to inhibit specific enzymes. This activity has led to their use in the development of various pharmaceutical agents used in the treatment of cancers and to combat harmful viruses, bacteria and parasites.Nucleoside Mimetics provides an intro
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Information
Topic
MedicineSubtopic
Biochemistry in MedicineI
N
T
R
O
D
U
C
T
I
O
N
Ara-A
(Antiviral)
Nucleocidin
(Antitrypanosomal)
Toyocamycin
(Antitumour)
FUDR
(Anticancer)
8-Azainosine
(Anticancer)
Ara-C
(Antileukemia)
structure
and
mechanisms
of
antiviral/anticancer
activity
. 12" 16
O
f
particular
interest
was
the
discovery
of
activity
in
L-nucleosides
(such
as
3TC™),
the
unnatural
nucleoside
enantiomers,
and
the
non-nucleoside
reverse
transcriptase
inhibitors
(NNRTFs)
TSAO-T
and
HEPT
(see
section
1
.
7
.
1
.
2
)
Although
there
has
been
great
interest
in
the
reverse
transcriptase
inhibitors,
there
are
many
other
known
and
potential
enzymatic
targets,
including
both
cellular
enzymes
and
virus-specified
enzymes,
with
which
nucleoside
mimetics
can
interact
as
substrates/competitive
inhibitors
.17
Antiviral
specificity
is
often
required
for
mini
mum
toxicity,
however
the
more
specific
inhibitors
are
often
the
most
prone
to
the
formation
of
virus-drug
resistant
strains.
Therefore
a
balance
is
often
required
between
drug
specificity
and
toxicity
in
order
to
minimise
the
problem
of
drug
resistance.
1.2
STRUCTURE
OF
NUCLEOSIDES
The
nucleoside
components
of
RNA
and
DNA
are
composed
of
a
sugar
moiety,
ribose
(1.1,
p-D-riboftiranose)
and
2-deoxyribose
(1.2,
2-deoxy-p-D-ribofuranose)
2
N
U
C
L
E
O
S
I
D
E
M
I
ME
T
I
CS
Table of contents
- Cover
- Half Title
- Title Page
- Copyright Page
- Contents
- Preface
- Chapter 1 Introduction
- Chapter 2 Synthesis of Conventional D-Nucleosides
- Chapter 3 Sugar Modified Nucleosides
- Chapter 4 Heterocyclic Base Modified Nucleosides
- Chapter 5 L-Nudeosides
- Chapter 6 C-Nucleosides
- Chapter 7 Carbocyclic Nucleosides
- Chapter 8 Acyclic Nucleosides
- Index
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Yes, you can access Nucleoside Mimetics by Claire Simons in PDF and/or ePUB format, as well as other popular books in Medicine & Biochemistry in Medicine. We have over 1.5 million books available in our catalogue for you to explore.