eBook - PDF

Nucleoside Mimetics

Name: Nucleoside Mimetics
ISBN: 9781482283143

Their Chemistry and Biological Properties

Claire Simons,

202 pages
English
PDF
Available on iOS & Android

eBook - PDF

Nucleoside Mimetics

Their Chemistry and Biological Properties

Claire Simons,

About this book

Nucleosides exhibit a broad spectrum of biological activity that generally results from their ability to inhibit specific enzymes. This activity has led to their use in the development of various pharmaceutical agents used in the treatment of cancers and to combat harmful viruses, bacteria and parasites.Nucleoside Mimetics provides an intro

Publisher

CRC Press

Year

2000

Edition

eBook ISBN

9781482283143

Topic

Medicine

Subtopic

Biochemistry in Medicine

I

N

T

R

O

D

U

C

T

I

O

N

Ara-A

(Antiviral)

Nucleocidin

(Antitrypanosomal)

Toyocamycin

(Antitumour)

FUDR

(Anticancer)

8-Azainosine

(Anticancer)

Ara-C

(Antileukemia)

structure 

and

mechanisms 

of

antiviral/anticancer 

activity

. 12" 16

O

f

particular 

interest 

was

the

discovery 

of

activity 

in

L-nucleosides 

(such 

as

3TC™), 

the

unnatural 

nucleoside 

enantiomers, 

and

the

non-nucleoside 

reverse 

transcriptase 

inhibitors 

(NNRTFs) 

TSAO-T 

and

HEPT 

(see 

section 

1

.

7

.

1

.

2

)

Although 

there 

has

been 

great 

interest 

in

the

reverse 

transcriptase 

inhibitors, 

there 

are

many 

other 

known 

and

potential 

enzymatic 

targets, 

including 

both 

cellular 

enzymes 

and

virus-specified 

enzymes, 

with 

which 

nucleoside 

mimetics 

can

interact 

as

substrates/competitive 

inhibitors

.17

Antiviral 

specificity 

is

often 

required 

for

mini

mum

toxicity, 

however 

the

more 

specific 

inhibitors 

are

often 

the

most 

prone 

to

the

formation 

of

virus-drug 

resistant 

strains. 

Therefore 

a

balance 

is

often 

required 

between 

drug 

specificity 

and

toxicity 

in

order 

to

minimise 

the

problem 

of

drug 

resistance.

1.2

STRUCTURE 

OF

NUCLEOSIDES

The

nucleoside 

components 

of

RNA

and

DNA

are

composed 

of

a

sugar 

moiety,

ribose 

(1.1, 

p-D-riboftiranose) 

and

2-deoxyribose 

(1.2, 

2-deoxy-p-D-ribofuranose)

2

N

U

C

L

E

O

S

I

D

E

M

I

ME

T

I

CS

Cover
Half Title
Title Page
Copyright Page
Contents
Preface
Chapter 1 Introduction
Chapter 2 Synthesis of Conventional D-Nucleosides
Chapter 3 Sugar Modified Nucleosides
Chapter 4 Heterocyclic Base Modified Nucleosides
Chapter 5 L-Nudeosides
Chapter 6 C-Nucleosides
Chapter 7 Carbocyclic Nucleosides
Chapter 8 Acyclic Nucleosides
Index

Trusted by 375,005 students

Access to over 1.5 million titles for a fair monthly price.

Study more efficiently using our study tools.

Frequently asked questions

Can I cancel at any time?

Yes, you can cancel anytime from the Subscription tab in your account settings on the Perlego website. Your subscription will stay active until the end of your current billing period. Learn how to cancel your subscription

Can I download books?

No, books cannot be downloaded as external files, such as PDFs, for use outside of Perlego. However, you can download books within the Perlego app for offline reading on mobile or tablet. Learn how to download books offline

What is the difference between the pricing plans?

Perlego offers two plans: Essential and Complete

Essential is ideal for learners and professionals who enjoy exploring a wide range of subjects. Access the Essential Library with 800,000+ trusted titles and best-sellers across business, personal growth, and the humanities. Includes unlimited reading time and Standard Read Aloud voice.
Complete: Perfect for advanced learners and researchers needing full, unrestricted access. Unlock 1.5M+ books across hundreds of subjects, including academic and specialized titles. The Complete Plan also includes advanced features like Premium Read Aloud and Research Assistant.

Both plans are available with monthly, semester, or annual billing cycles.

How does Perlego work?

We are an online textbook subscription service, where you can get access to an entire online library for less than the price of a single book per month. With over 1.5 million books across 990+ topics, we’ve got you covered! Learn about our mission

Do you support text-to-speech?

Look out for the read-aloud symbol on your next book to see if you can listen to it. The read-aloud tool reads text aloud for you, highlighting the text as it is being read. You can pause it, speed it up and slow it down. Learn more about Read Aloud

Can I read on my tablet or smartphone?

Yes! You can use the Perlego app on both iOS and Android devices to read anytime, anywhere — even offline. Perfect for commutes or when you’re on the go.
Please note we cannot support devices running on iOS 13 and Android 7 or earlier. Learn more about using the app

Is Nucleoside Mimetics an online PDF/ePUB?

Yes, you can access Nucleoside Mimetics by Claire Simons in PDF and/or ePUB format, as well as other popular books in Medicine & Biochemistry in Medicine. We have over 1.5 million books available in our catalogue for you to explore.

Nucleoside Mimetics

Their Chemistry and Biological Properties

Nucleoside Mimetics

Their Chemistry and Biological Properties

About this book

Information

Table of contents

Trusted by 375,005 students

Frequently asked questions